Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells

Tissue-resident memory T cells that express TCF1 or ID3 exhibit stem-like properties and regulate memory heterogeneity and recall @sciimmunology.bsky.social @thedohertyinst.bsky.social www.science.org/doi/10.1126/...

Halloween costumes to scare scientists (by @twisteddoodles.bsky.social) 🧪

Kyoto University scientists converted ordinary T cells into stable regulatory T cells that can suppress autoimmune disease in mice. This approach may enable personalized, targeted cell therapy for inflammatory diseases. www.science.org/doi/10.1126/...

Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold. Want to get a tough sample, like lung, looking like this? Read more! www.biorxiv.org/content/10.1...

Review @natrevcancer.nature.com @stjuderesearch.bsky.social Epigenetic regulation of T cell exhaustion in cancer www.nature.com/articles/s41...

I'm incredibly honoured to be presenting my research on CD8 TRM in liver fibrosis within the ‘Immune interactions in tissues’ session at @britsocimm.bsky.social Congress 2025! Added to this, I’m also excited to be selected to share this work as part of the Bright Sparks Postdoc session 🥳

Yang, Farber and colleagues @columbiamed.bsky.social show how lung tissue resident memory T cells optimize protection through IL-10 production which regulates #macrophage-mediated #inflammation in the lungs. rupress.org/jem/article/... #InnateImmunity #MucosalImmunology

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science! www.science.org/doi/10.1126/...

More coming on what this means but this was one of those stories that took almost a decade to come together but was well worth the time. Also check out a companion piece on @biorxiv by Patrick Brennan!

Our iconic immune cell badges are back for #BSI25, and you get to choose the next design! 🎨🧫 Vote now and help decide which badge will join the line-up in Liverpool 👇 Cast your vote here🔗: https://bit.ly/46DtHzy

Pre-division TCF1 drop determines long-term CD8 T cell fates @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

Without an understanding of immune tolerance, organ transplantation will not be possible. Also, their discoveries opened avenues for cancer and auto immune disease therapies. Congratulations to these year's awardees of the nobel prize in physiology or medicine. bit.ly/4mC0Gc5

Congratulations to Fred Ramsdell, Mary Brunkow and Shimon Sakaguchi - the 2025 Winners of the Nobel Prize in Physiology or Medicine. #Treg_cells #Foxp3 #Immune_regulation

Review @natrevimmunol.nature.com Regulators of CD8+ T cell exhaustion www.nature.com/articles/s41...

Review @natrevgastrohep.nature.com @ucl.ac.uk @pallettlab.bsky.social @brownromeo.bsky.social Tissue-resident memory CD8+ T cells: master deciphers of the hepatic environment www.nature.com/articles/s41...

🎉 Hot off the press! Our new review on liver resident CD8+ T cells is here - exploring the dual nature of these cells either as protective "Jekyll" 😇 or pathogenic "Hyde” 😈 Dive in to see how the liver microenvironment shapes TRM immunity, pathology & therapeutic potential!

Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

A liver-infiltrating CD4+ Tfh1 cell response predicts HCV control, hepatitis, and seroconversion during acute infection @jclinical-invest.bsky.social @nationwidekids.bsky.social www.jci.org/articles/vie...

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset @biorxivpreprint.bsky.social @nidcr.bsky.social #NCI www.biorxiv.org/content/10.1...

CD103 facilitates the interaction of naive CD8+ T cells with E-cadherin-expressing dendritic cells that in turn provide cytokine-mediated cues to promote their differentiation into memory-phenotype effector T cells @cp-immunity.bsky.social www.cell.com/immunity/ful...

T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors www.mucosalimmunology.org/article/S193...

In @jem.org, Arase, Murakami, Takeda et al. identify RUNX2 and BHLHE40 as key factors driving tissue-resident memory T cells (TRM) characteristic of #Crohns disease. Blocking these transcription factors mitigated the cytotoxic TRM phenotype in human disease samples. rupress.org/jem/article/...

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence @jimmunol.bsky.social @thelundlab.bsky.social academic.oup.com/jimmunol/adv...

Fantastic to see this out 👏 ScRNAseq data from 77 patients as an atlas for all to use. Used to identify a new subpopulation of pro-inflammatory scar-associated macrophages which promote fibrosis from our friends in the Ramachandran lab. 🧪 #liversky #immunosky www.biorxiv.org/content/10.1...

Single-cell atlas of human liver and blood immune cells across fatty liver disease stages reveals distinct signatures linked to liver dysfunction and fibrogenesis @natimmunol.nature.com www.nature.com/articles/s41...

Absolutely brilliant review #Freshoffthepress www.nature.com/articles/s41... #CD8Tcelldysfunction

Just submitted my abstract to #BSI25, so excited to head up to Liverpool for another Congress! Who else is travelling to the north west? 🤩

One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth nature.com/articles/s43...

Building a professional network can have a big impact, but attending meetings isn't always easy. The BSI Career Enhancing Grant can help with the costs of joining networking events and connecting with peers. Find out more & apply by 24 September: https://bit.ly/3QedNDL

In case you missed it: @juliakarjalainen.bsky.social co-authored this recent review with our lab on glia in barrier organs in @mucosalimmunol.bsky.social We summarise cutting-edge findings and highlight future directions for the field - timely reading: www.mucosalimmunology.org/article/S193...

Beautiful talk from @mahimaswamy.bsky.social at #EMBObarrierTissues. Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes | bioRxiv share.google/UroEHTZJI7tk...

👶✈️ Balancing caregiving and academic travel? Join Dr. Laura Pallett for "The Dual Demands of Academic Travel and Caregiving" 🗓️ Sept 25 | 🕒15:00 CEST 🔗https://tinyurl.com/yefis2025-ia2 Hosted by the Improving Academia group of yEFIS

Safe to say #IUIS2025 was a blast! A packed and wonderful programme, seeing old friends and new, an immunology run and one hell of a congress party 🎉 What more could you ask for? Here’s to #IUIS2028 in Toronto 🇨🇦

Succinate enhances mitochondrial fitness and induces epigenetic reprogramming to promote CD8+ T cell stemness, thereby augmenting antitumor immunity www.cell.com/immunity/ful... @cp-immunity.bsky.social

Multimodal profiling reveals tissue-directed signatures of human immune cells altered with age @natimmunol.nature.com @teichlab.bsky.social @donnafarber.bsky.social www.nature.com/articles/s41...

NOW in @natcomms.nature.com my postdoc work @uofgsii.bsky.social @immunememorylab.bsky.social 🫁 structual cells retain an imprint of IAV infection💪 Rapidly controlling a localized antiviral response BRFORE memory-T cells are required! rdcu.be/eyQ0F #ImmunoSky #PulmSky @wellcometrust.bsky.social

Thanks to the MacLeod lab @georgeefinney.bsky.social @kerrie @tom @cliodhna And all other collaborators/co-authors @john @jagtar @fraser @mariekedoesscience.bsky.social @euanbrennan.bsky.social @Kathleen @Jay @Georgios @Vanessa @Claire @Yoana @Nigel @Massimo and @immunememorylab.bsky.social

Gorgeous study exploring the rules of Trm formation and maintenance from @anandasabapathylab.bsky.social . Glad our lab could be part on this important effort!

TGFβ-mediated signals involving IL-4 and PD-1 enable CD8+ T cells to establish tissue-residence in skin www.nature.com/articles/s41... www.nature.com/articles/s41... @natimmunol.nature.com www.nature.com/articles/s41...

The global burden of liver cancer is increasing. 📈 Hepatocellular carcinoma (HCC) accounts for approximately 80% of cases globally. 💡 A new Commission outlines evidence-based recommendations for action to reduce the global HCC burden: tinyurl.com/yzxvktkw

And we're off! Welcome all to our annual meeting 'Diversity in Immunology' 🥳 We have an exciting day ahead 🤩 Let us know your favourite moments of the day by using our hashtag! 😊 #LIG25

'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.' #immunology #immunosky onlinelibrary.wiley.com/doi/10.1002/...

#Diversity in #immunology - don’t miss talks on sex-specific mechanisms in lupus, rethinking progress in STEM, & multi-system response to viral infection! @london-immuno.bsky.social 🦃 Early bird registration closes 25 June - make use of this discount! #LIG2025 🔗 bit.ly/3CLQTj7

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

Thames Water is now controlled by two US credit powerhouses: Silver Point Capital and Elliott Management. Their game - asset stripping, profiteering, slick PR, devour; to get high returns. Govt can put an end by bringing water into public ownership, but refuses. People's misery to deepen.

We're not the first to use IL-12 as an adjuvant - but having worked on IL-12 for >30 years this was still a surprise at how much this study taught us about mRNA vaccines and their utility. Here are two others below: www.science.org/doi/10.1126/... @cytokinesociety.bsky.social

I’m pleased to share my latest work, published in Science Advances. In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections. #immunology #immunosky www.science.org/doi/10.1126/...

⚠️Abstract submission deadline approaching! Share your research with the London immunology community for our ‘Diversity in Immunology’ conference on Friday 11 July. ➡️Submit here by Sunday 1 June: bit.ly/3X76KzF #LIG2025