@chinweetan.bsky.social
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reposted by
Millennium Science
about 1 month ago
How do cytokines tune immune helpers? Nature Immunology study from
@groomlab.bsky.social
’s lab at
@wehi-research.bsky.social
used
@10xgenomics.bsky.social
single-cell & spatial tech to map T follicular helper (TFH) cells diversity. đź”—
www.nature.com/articles/s41...
#Immunology
#SpatialBiology
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reposted by
Joanna Groom
about 1 month ago
Thanks
@10xgenomics.bsky.social
for the shout out and for making your data publicly available Why waste precious resources ($$) to reinvent data that already exists? Cool human datasets ready to go (Although now we have scratched the spatial itch, we may need to do more
@chinweetan.bsky.social
🤔)
add a skeleton here at some point
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reposted by
Joanna Groom
about 2 months ago
"Biology is messy and sometimes we need to embrace the mess"
www.nature.com/articles/s41...
Huge thanks to Amy Weinmann and Danielle Chisolm for beautifully highlighting our work and the importance of our approaches
@natimmunol.nature.com
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TFH cell programs by pathogen and species - Nature Immunology
CD4+ T follicular helper (TFH) cells that develop in response to a range of pathogens share aspects of a common gene signature. However, cytokine environments, rather than pathogen class, shape diversity in programming potential.
https://www.nature.com/articles/s41590-025-02284-7
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reposted by
Joanna Groom
about 2 months ago
Thrilled to make the cover of
@natimmunol.nature.com
this month. A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago)
@wehi-research.bsky.social
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reposted by
WEHI (The Walter and Eliza Hall Institute of Medical Research)
about 2 months ago
WEHI scientists led by
@groomlab.bsky.social
‬
@chinweetan.bsky.social
map how Tfh cells tailor instructions based on infection type. A step toward smarter vaccines and therapies. đź“„ In
@natimmunol.nature.com
:
www.nature.com/articles/s41...
đź”— Read more:
www.wehi.edu.au/news/unlocki...
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reposted by
Carolien van de Sandt
2 months ago
Great work by
@chinweetan.bsky.social
, @Len Dalit and
@groomlab.bsky.social
and her team understanding the signatures behind T folicular helper heterogeneity! ⬇️
#ImmunoSky
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reposted by
Joanna Groom
2 months ago
Thrilled to have our latest research
@wehi-research.bsky.social
published in
@natimmunol.nature.com
www.nature.com/articles/s41...
This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician
@chinweetan.bsky.social
Thread below...
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Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity - Nature Immunology
Dalit, Tan and colleagues provide a multiomic profile of T follicular helper (TFH) cells responses to diverse pathogens, revealing a blueprint for transcriptional flexibility and new tools to interrog...
https://www.nature.com/articles/s41590-025-02258-9
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reposted by
Jinjin Chen
8 months ago
Thrilled to share our latest publication! Huge thanks to the team
@chinweetan.bsky.social
, Melissa Davis, Ahmed Mohamed and
@bhuvad.bsky.social
for making this possible! Questions welcome! Would love to hear your thoughts on our approach!
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Very excited that our work is out in Bioinformatics! mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis
academic.oup.com/bioinformati...
@wehi-research.bsky.social
led by the talented Jinjin Chen
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mastR: an R package for automated identification of tissue-specific gene signatures in multi-group differential expression analysis
AbstractMotivation. Biomarker discovery is important and offers insight into potential underlying mechanisms of disease. While existing biomarker identific
https://academic.oup.com/bioinformatics/article/41/3/btaf114/8082930
8 months ago
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Super glad to me part of this great team and work! Amazing!
add a skeleton here at some point
8 months ago
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reposted by
Joanna Groom
8 months ago
Very excited our work out in
@jem.org
“Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection”
@wehi-research.bsky.social
led by talented (and determined) PhD student
@benjbroom.bsky.social
Thread below.
add a skeleton here at some point
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reposted by
Journal of Experimental Medicine
8 months ago
@benjbroom.bsky.social
et al.
@groomlab.bsky.social
show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells
rupress.org/jem/article/...
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reposted by
DrLachie
11 months ago
Have seen lab mates come and go but a great group to end 2024 with. I don't like it when some mention they were finishing grade 6 when I was starting in my role here though....
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reposted by
Rita Strack
11 months ago
I could not be more thrilled to announce the Nature Methods
@naturemethods.bsky.social
Method of the Year is Spatial Proteomics! Please see our editorial as a roadmap to the fantastic content in this special issue!
www.nature.com/articles/s41...
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Method of the Year 2024: spatial proteomics - Nature Methods
Approaches for profiling the spatial proteome in tissues are the basis of atlas-scale projects that are delivering on their promise for understanding biological complexity in health and disease.
https://www.nature.com/articles/s41592-024-02565-3
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reposted by
Jim Mansfield
11 months ago
#Multiomics2024
was amazing and I was very proud to be invited to speak for
@standardbiology.bsky.social
. Here’s the cartoon version. Huge thanks to
@aruthak.bsky.social
for bringing it all together.
#spatialbio
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