Glycogen is ubiquitinated in vivo! And there is a clever method to detect it. It had been a privilege seeing this story come together by my colleagues in the @komanderlab.bsky.social. This will no doubt have important implications for metabolism.

Another postdoc position for my lab is now open. This one is for a biochemist/cell biologist who really likes mitochondria and ubiquitin. If this is you, please apply here: www.seek.com.au/job/91277535

WEHI researchers have led a major global effort to create the first authoritative atlas for E3 ligases, resolving more than 18 years of inconsistencies in the ubiquitin field. Study led by Dr Ngee Kiat ‘Jake’ Chua & Dr Rebecca Feltham in @cellpress.bsky.social www.wehi.edu.au/news/new-enz...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Lipids Meet Immunity: Metabolic Control of cGAS-STING Having worked in lipid metabolism and cGAS-STING, I have an appreciation for the regulation of cGAS-STING by lipids, which I co-wrote. www.mdpi.com/2813-7086/3/... @wehi-research.bsky.social @sahmri.bsky.social

Come do a PhD with me and @trevor-lithgow.bsky.social at @monashuniversity.bsky.social ! We’re at the leading edge of pathogen biology using cutting edge Cryo-EM and AI-driven genetic screens to uncover the mysteries of outer membrane biology. Reach out to me for a chat! macsys.org/phd-scholars...

I'm hiring! If you are a structural biology postdoc with strong cryo-EM experience who is excited about mitochondrial membrane complexes, please apply! WEHI is a great place to work with access to state-of-the art cryo-EM facilities. Apply here 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex...

After a long (but fun!) postdoc journey, I am very excited to share that I will start my own lab in the Ubiquitin Signalling Division at WEHI. We will study how ubiquitin controls mitochondrial health and its role in neurodegenerative disease. Hiring soon!

🧠 Dr Callegari shares the role collaboration has made in the WEHI group's research, as their insights deepen understanding of genetic mutations of Parkinson's disease & new avenues for drug discovery. 👉 Read more: bit.ly/4sKbh9s @wehi-research.bsky.social

💡Solving decades-long mysteries with cryoEM. 💥Brilliant science + best tech = life-saving medical research. Shaping the future of health through bold new approaches. #ParkinsonsDisease

Big cheers to our 12 researchers awarded $14M in NHMRC Ideas Grants! Funding will drive pioneering research into #Parkinson’s, #coeliac disease, #cancer and more, shaping the future of health. 🧵1/2

A big year for the lab! We hosted Australia’s first ubiquitin summit in Lorne, Published the structure of PINK1 on a mitochondrial translocase array, Reported a new PLpro inhibitor for long COVID, Celebrated 3 PhD and 1 honours completions, Went on a lab footy trip, 🏈 Won the Eureka prize!! 🏆

We’re hiring a research assistant! If you have experience in protein production and purification (bacterial and/or insect systems) and are interested in early-stage drug discovery, please apply! 👇 wehi.wd3.myworkdayjobs.com/broadbean_ex....

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility. www.science.org/doi/10.1126/...

Really enjoyed the #ASBMB2025 conference in Brisbane this week. It's an honour to get to present to this audience and winning an oral presentation prize was an unexpected bonus!

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5) doi.org/10.1101/2025.09.24.678028 #proteindesign

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

Very exciting to see the @wehi-research.bsky.social PINK1 Parkinson’s Disease research team win the Eureka Prize for Scientific Research. Amazing achievement by a brilliant team! @eurekaprizes.bsky.social

The Institute for Molecular Bioscience is seeking an exceptional academic leader to be the new Director of the Centre for Chemistry and Drug Discovery and lead our centre consisting of 10 group leaders, 40 staff and approximately 50 HDR students. Come and join us in sunny Brisbane!

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Our June Newsletter highlights IUBMB activities including a note from the President and updates on the IUBMB Trainee Initiative ➡️http://bit.ly/45ai6r1

PINK1 Parkinson's Disease Research Team @wehi-research.bsky.social is a finalist in the @unsw.edu.au Eureka Prize for Scientific Research. Learn more: youtu.be/senXARXzO20 #EurekaPrizes @komanderlab.bsky.social @zhongyangan.bsky.social @sylviecallegari.bsky.social @nskirk.bsky.social

🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social. Excited for the awards ceremony on Sept 3rd! @eurekaprizes.bsky.social @wehi-research.bsky.social

“Why do we sleep” has been a surprisingly hard question. But it looks like the answer may be “ Because we breathe”. Our mitochondria need a break!

📣 Calling all ubiquitin aficionados - one week to go before abstract deadline (July 18th)!! Join us on the coast in Lorne, Australia. www.lorneubiquitin.org #ubiquitin

Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

Researchers in Science have developed a tool to silence specific mitochondria-encoded mRNAs in living cells, which could help scientists understand the origins of certain mitochondria-related diseases. scim.ag/3F6Wm5d

Excited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...

Stunning photo of Mars on the cover of Science this week! And super proud that our structure of PINK1 stalled at mitochondrial translocases also gets a cover mention 😊. It's now out in print on page 303!

Excited to share news from the lab out in Nature Communications – A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID www.nature.com/articles/s41... @wehi-research.bsky.social

Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org See you there!

Human PINK1 at a TOM-VDADC array Structure of the Week/Month/Year(?)! 9eih. Sylvia Callegari...David Komander, Science 13 March 2025. #coot Fancy mode Copyright/license-free - i.e. freely reproducible. Coot 1.1.14 coming soon!

PINK1/Parkin-dependent mitophagy caught in situ by cryo-ET! New preprint www.biorxiv.org/content/10.1... led by @kev-in-situ-et.bsky.social. This has been a long-standing goal of team @mito911.bsky.social within the @asapresearch.parkinsonsroadmap.org initiative.

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Amazing talk by @sylviecallegari.bsky.social so great to see the TOM complex back at Lorne, and capturing substrate in the channel of Tom40 … fabulous

Many thanks to Sylvie Callegari @wehi-research.bsky.social for her beautiful spotlight describing our recent discovery of localized, and ROS-regulated, protein degradation at mitochondrial import gates! www.sciencedirect.com/science/arti...

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social

A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this! Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... Original article: www.cell.com/molecular-ce...