Ever wondered why some antibiotics are made by Streptomyces on agar plates but not in liquid cultures? Read this work on redox control of antibiotic biosynthesis. Led by katienoble241.bsky.social and Rebecca Devine, and in collaboration with @barriewilks.bsky.social journals.asm.org/doi/10.1128/...

After 8 wonderful years in Norwich, 3 at UEA and 5 at the JIC it’s time to say goodbye. I will miss each and every amazing person I’ve had the pleasure of working with or meeting here. It truly is a fine city.

Nice to see our recent work on the fascinating KorAB system be featured on the back of @johninnescentre.bsky.social Advances! Read the full paper here: www.nature.com/articles/s41...

Check out our lab's new work on a CTP-independent ParABS system. Some fantastic work from Kirill et al!

Have a read of this simply phenomenal work on the weird and wonderful GTAs from star Fellow (and office mate) Emma Banks et al

"That telomere phages are so prevalent means that they are a selective force, one that we know little about. We now want to understand how the telomere-toxin is secreted and also understand how this ‘telocin’ wheedles its way into unsuspecting bacterial neighbors” www.science.org/doi/10.1126/...

The paper is now live: academic.oup.com/mbe/article/... Absolutely delighted to play a role in this fascinating story!

The second great paper concerns the discovery in Eva Top's group that an enigmatic protein encoded by IncP-1beta plasmids modulates the IncP-1 circuitry in E. coli to make the plasmid a burden in this host: Elg et al recently accepted in Molecular Biology and Evolution doi.org/10.1093/molb...

#Postdoc position - at the University of Marburg (Germany), funded within our ERC Advanced Grant "C-SWITCH" Focus: CTP-dependent molecular switches as a new principle of cellular regulation in bacteria (including bacteriophages) Apply by 04 May: stellenangebote.uni-marburg.de/jobposting/2...

Almost 8 years after starting this project finally happy to share the main research from my PhD! Couldn't have done it without the amazing help from @ainsley-beaton.bsky.social! We untangled a fascinating new redox sensor with the most extraordinary growth phenotype (I'm biased) in Streptomyces!

Further insight into how CutRS functions in Streptomyces and some thoughts on how its redox state detection via conserved dual cysteine residues in the extra cellular domain of a sensor kinase may be present in almost all bacteria @tommclean.bsky.social @matthutchings.bsky.social

Very happy to share this work led by @tommclean.bsky.social and @ainsley-beaton.bsky.social. The conserved Streptomyces sensor kinase CutS senses disulphide bond formation outside the cell. If it fails CutS activates CutR which switches on production of foldase HtrA3 www.biorxiv.org/content/10.1...

It's done. I've deactivated my twitter account, good riddance.

Redox control of antibiotic biosynthesis in Streptomyces. Remarkable work led by @katienoble241.bsky.social and Rebecca Devine demonstrates why antibiotic biosynthesis is often switched on in solid cultures and off in liquid. www.biorxiv.org/content/10.1...

Nice blog from the Lister Institute on our recent work on KorAB and long-range gene silencing on multi-drug resistance plasmid!!! @tommclean.bsky.social @johninnescentre.bsky.social lister-institute.org.uk/biology-is-f...

Cool “Behind the paper” article on our recent KorB-KorA sliding clamp-locking clamp story. I remember Chris Thomas and Lewis Bingle (Birmingham) taught me about these proteins when I was an undergrad, and I kept remembering they said the mechanism was not clear!!! www.nature.com/articles/s41...

OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein by Tung Le & co @johninnescentre.bsky.social www.nature.com/articles/s41...

Super excited to share the peer-reviewed version of the KorAB paper. Amazing to work such talented collaborators and thanks to the reviewers for making the work even better! www.nature.com/articles/s41...

New paper in PLOS Biol with @graciellehigino.bsky.social et al.: "Postdoctoral scientists are mentors, and it is time to recognize their work". We argue that ensuring that post-docs receive proper credit for ALL their labour would benefit all academia.

Finally made the pilgrimage to Micropia! Dragged a whole bunch of friends to learn about microbes with me!

Our review - Antibiotics from rare actinomycetes, beyond the genus Streptomyces - is now online Thanks to coauthors @jonathanparra.bsky.social @ainsleybeaton1 @ryanfseipke @barriewilksjic @matthutchings.bsky.social and editors Toni Gabaldón & Luiz Carvalho for the invitation

First post in this place 💙our last story on the #ParABS system and the unique behaviour of #ParB during the #Bdellovibrio cell cycle is now alive at #PLOSGenetics! We love the revised version (thanks to the 3 super reviewers & great editorial advice). Read it here dx.plos.org/10.1371/jour...

Finally some good news, UK rejoins Horizon Europe! www.bbc.co.uk/news/uk-6673...