We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4 Preprint: www.biorxiv.org/content/10.6... Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

After a long (but fun!) postdoc journey, I am very excited to share that I will start my own lab in the Ubiquitin Signalling Division at WEHI. We will study how ubiquitin controls mitochondrial health and its role in neurodegenerative disease. Hiring soon!

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026

A big year for the lab! We hosted Australia’s first ubiquitin summit in Lorne, Published the structure of PINK1 on a mitochondrial translocase array, Reported a new PLpro inhibitor for long COVID, Celebrated 3 PhD and 1 honours completions, Went on a lab footy trip, 🏈 Won the Eureka prize!! 🏆

‼️Towards the end of #AusUb25, we caught up with Jonathan Pruneda to discuss ubiquitin signalling and its relationship with host-pathogen interactions. It was an amazing conference and such a great chance to meet people from across the ubiquitin field 🤩

‼️ Following on from our “M1 chains everywhere!” session at #AusUb25 we took the chance to interview one of the pioneering researchers in this field, Kazuhiro Iwai. Have a look below! ✨✨✨

‼️Have a listen to a little about Kylie Walter’s exciting new research, conference talk, and her experience at #AusUb2025. What did she enjoy most about the conference? More interviews to come in the next week so stay tuned 😁

‼️It was wonderful to have Professor Kay Hoffmann at the #AusUb25 - and even better to get the chance to interview him! Hear about his experiences in industry and academia as well as his love for proteins😁

#ArtAdventCalendar Day 5 Ubiquitin - Spraypaint on conrete

ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

💯 'A scientific figure (or art in general) is more than a function of communication, it’s a reflection of how we interact with, interpret, and perceive science.'

It’s hard to believe that #AusUb2025 has already come to an end 😢. Don’t worry though - we’ll still be posting our speaker interviews in the next couple of days. Here’s what Sonja Lorenz thought of the Australian Ubiquitin Summit. 👇

What a fantastic few days at The *inaugural* Australian Ubiquitin Summit 🤩 #UbiquitinByTheBay It was fun to contribute behind the scenes in the lead-up, help chair the opening session, host lightning talks, and dive into conversations during the poster session and EMCR panel discussions.

Is there any chain more enigmatic than K27-Ub? 😍 #UbiquitinByTheBay #AusUb2025

Is there any biomolecule thats not #Ubiquitinated ? 🫣 It was super fun to chair my fav session on 'Ubiquitinating EVERYthing' during the kickstart event of #AusUb2025

Have you already spotted some ‘local residents’ at Lorne? Share photos and tag #AusUb2025!

We were also honoured to have Ebony Hickey welcoming everyone to Gadubanud country with a powerful story. Indigenous Australians have a long and continuing history, and were the first scientists on this land.

Today is the day! The Inaugural Australian Ubiquitin Summit #AusUb2025 was officially opened by committee chair David Komander.

⏰#AusUb2025 is TOMORROW!!! Here’s our final pre-conference interview - have a listen to Bernhard Lechtenberg’s thoughts on conference organising and what he’s most looking forward to! @lechtenberglab.bsky.social

Any fun conference moments to share? Impressed by any of our speakers? Got any cute wildlife pics 🦜? Share your #AusUb2025 moments using the hashtag! Don’t forget to follow us on socials by scanning the QR codes ✨✨ We can’t wait to see you in Lorne tomorrow 😉

Can't wait for #AusUb2025 to start tomorrow ⏰ ? Head over for a sneak peak 👀 on what's coming! 👇 lorneubiquitin.org/program-2025

Watch this interview with our organising committee’s resident PROTAC expert Rebecca (Bekky) Feltham to learn about what went into organising the Targeted Protein Degradation (TPD) Day and more about the conference! 📝

⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!

⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?). More interviews to come in the next few days so watch this space 😉

Stay tuned for some ✨exclusive✨ interviews from our organising committee members (including committee chair David Komander!).

📢 All ubiquitin aficionados! 📢 We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️ Are you ready for talking ubiquitin by the bay? 🗓️ 20-23 Nov 📍Mantra, Lorne, VIC Chaired by David Komander (@komanderlab.bsky.social) #AusUb2025

#ResearchExplained! Using BEST-HSQC NMR, Dr Rashmi Agrata from Dr Ranabir Das's team at NCBS team tracked ubiquitin deamidation in real-time, revealing varied deamidase efficiencies despite similar structures. Read here: bit.ly/3L56RIR ✏️Christeen Paulson

#NMRchat Monitoring Protein Deamidation in Real Time Using NMR https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/mrc.70045?af=R

Researchers from WEHI’s Parkinson Disease Research Centre have won the 2025 UNSW Eureka Prize for Scientific Research. The team has been honoured for their research unravelling how PINK1, a key protein linked to early-onset Parkinson’s disease, works. 🔗 www.wehi.edu.au/news/eureka-...

Australia’s First Ubiquitin Summit is here! 🥳 📍Lorne, Victoria | 🗓️ 20–23 November 2025 Join us on the scenic coastline of Lorne for 4 days of cutting-edge ubiquitin science, featuring a fantastic lineup of international speakers covering all corners of the Ub world—from mechanisms to therapeutics

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

Excited to share news from the lab out in Nature Communications – A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID www.nature.com/articles/s41... @wehi-research.bsky.social

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery? @felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities. Read more: tinyurl.com/3y4kv2bp #LMBResearch🧪

Join us at the beach for the first Australian Ubiquitin summit from 20-23 Nov! 🏄‍♀️ Check out the amazing speakers here: www.lorneubiquitin.org And, why not stay a little longer and join the International Symposium on Autophagy from 16-20 Nov, also in beautiful Lorne ☀️. www.isa11.org See you there!

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis www.nature.com/articles/s41...

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Come and do some chemistry for biology with us!

DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...

If making chemical tools for biology excites you, consider applying to the NCBS graduate program! My lab plans to hire 1–2 graduate students this cycle. More info on my lab @ dyecraftlab.com

Check it out! Another novel RNA modification - ADP-ribosylation - that was previously only known on proteins. A cousin to #glycoRNA 👏 www.nature.com/articles/s41...

There are lots of hydrophobicity scales and perhaps the most well known and used is that from Kyte & Doolittle If you ever use that scale, I recommend reading the original paper and noting the authors' pragmatism and honesty about manual adjustments and using intuition doi.org/10.1016/0022...

The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution Thanks for coming to my TED talk

🚨 The #Ubiquitin Congress is back in Würzburg! 🚨 Excited to host it again, June 2-4, 2025! 🌟 ✨ Still time to submit your abstract for a Short Talk! 🗓️ Registration Deadline: March 1st 📝 Abstract Submission Deadline: April 15th Don’t miss out—register now! ➡️ www.ubiquitin-wuerzburg-2025.de

We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳 Re-posts appreciated. www.nature.com/naturecareer...

Really enjoying kicking off the week with this new, excellently-written review on #ubiquitin from a structural perspective - so useful to step back every now and again and get an eagle's eye view on the field! www.cell.com/molecular-ce...

"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers. www.cell.com/molecular-ce...

Review: Ubiquitin—A structural perspective @rashmiagrata.bsky.social www.cell.com/molecular-ce...

New to #ubiquitin? Been with it for a while? Either way this review may be for you 🤩 Excited to share our review article in @molcell.bsky.social, diving deep into everything #ubiquitin Read here 👉: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F... @cellpress.bsky.social @wehi-research.bsky.social