New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

#ArtAdventCalendar Day 5 Ubiquitin - Spraypaint on conrete

Rewriting the code of plant immunity go.nature.com/475WgV7

Proud to be involved in this great paper describing a novel mechanism of #synuclein aggregation with implications for potential #PD treatment, don’t miss it! 👇🏼👇🏼👇🏼 Congratulations to the team! www.embopress.org/doi/full/10....

Excited to join the Nordinfect meeting on #infection #inflamation and #immunology. Great chance to meet the community #NDI3 @fzborstel.bsky.social ndi3.fz-borstel.de?trk=public_p...

Big news! Our group has joined the University of Hamburg — we’re excited for the opportunities and collaborations ahead! #Hamburg

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation??? Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

Happy to see our review out in ChemBioChem @chemistryeurope.bsky.social in which we describe the tools and strategies for deciphering linkage type-specific #ubiquitin signalling: doi.org/10.1002/cbic.... Thanks to Julian for spearheading this, and to Camilla and Dominik for important contributions.

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW 🥳 🍾 🙌 @katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Amazing !! Antiproteolysis peptides (APPs), identified by artificial intelligence, stabilized TF by inhibiting E3 ligase to induce resistance. Targeted Inhibition of Protein Degradation #TIPD #PPSTasis www.science.org/doi/10.1126/... Commentary www.science.org/doi/10.1126/...

Excited to share our latest work, now out in @lsajournal.org. we show that the E3 ligase HOIL-1 can ubiquitinate many different saccharides and describe a chemoenzymatic platform to generate ubiquitinated sugars as tools for studying non-proteinaceous ubiquitination.

www.ft.com/content/6328... Greenpeace has blocked cultivation of Golden Rice braking an innovation slated to save lives by enriching diets w/ vitamin A. In a world beset by food insecurity,climate change,water scarcity & conflict,the future of rice is mired in a stew of science, politics & economics

Great Review on TOR signalling: A Master Regulator in Plant Growth, Development, and Stress Responses #PPStasis #proteostasis #autophagy #Stressbio #Plantsci www.annualreviews.org/content/jour...

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery? @felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities. Read more: tinyurl.com/3y4kv2bp #LMBResearch🧪

🥳 Out now @embojournal.org! Interferon induces a new class of p62 bodies, with #antiviral & #immunotherapy implications. p62 is usually linked to #autophagy — but not here. These are driven by PARP14-mediated ADP-ribosylation & rely on #ubiquitin #proteasome system. www.embopress.org/doi/full/10....

Protein N-terminal modifications - Feature Review and cover in the recent issue of @cp-trendsbiochem.bsky.social Thanks to all authors, Editor @sanniejculbertson.bsky.social and reviewers for great work and support! @ispt-proteinterm.bsky.social www.cell.com/trends/bioch...

#HeardToday “You can’t solve mechanisms with genomics. For that you need to go to the trenches and do BIOCHEMISTRY!”

2 papers in @science.org this week uncover wheat tandem kinase function. Working in parallel, the authors of each paper show that two different tandem kinases converge to activate the same NLR! www.science.org/doi/10.1126/... www.science.org/doi/10.1126/... #PlantScience

Amazing story from #MolecularTherapeutics faculty @robzonculab.bsky.social with lead author @aakritijain.bsky.social describing membrane protein degradation in the lysosome. Congratulations!! www.science.org/doi/10.1126/...

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

The next frontier in #autophagy is understanding how it functions across cell types to maintain organismal homeostasis. w/ @moritznowack.bsky.social lab, we present TWO #preprint on cell type spec. autophagy in root hairs‼️ #plantscience www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Back-to-back on bioRxiv by @plantophagy.bsky.social and @moritznowack.bsky.social Cell-type specific upregulation of autophagy in Arabidopsis root hair cells promotes 1) root hair lifespan by suppressing cell death 2) plant salt stress resilience by ion sequestration See links to 2 papers below!

#PlantSciJobs #PlantSciJob 10 PhD positions: Communication + Dynamics of Plant Cell Compartments Research Training Group @unihalle.bsky.social and @ipbhalle.bsky.social Start: July 2025 Deadline: 31 March 2025 www.deutsche-botanische-gesellschaft.de/en/job-openi...

Yeii! nice to see our molecular pharming manuscript in its final form. Congrats to all authors!

Viral coat proteins are perceived by the RING1–IBR–RING2-type ubiquitin ligase (RBRL) #PlantSci #Ubiquitin #proteostasis www.nature.com/articles/s41...

Vector-borne viral pathogens are threats to crops, and so trigger plant immune responses. Studying rice, authors @nature provide molecular-level insights into the first steps of plant antiviral response. www.nature.com/articles/s41...

Yesterday we have just submitted our manuscript - you can find an updated version of our #preprint led by @manuelgonzalezfuen.bsky.social "Bacteria use processing body condensates to attenuate host translation during infection" with some new data on #bioRxiv 🤓 👇 www.biorxiv.org/content/10.1...

We are looking for a postdoc to study the impact of interspecific variation of ELF3 at the #mlu-halle within the EU-funded research consortium #ValuePlant. www.verwaltung.uni-halle.de/dezern3/Auss... Please share within your networks!

For all of you who cannot access pubmed, here is a good alternative: europepmc.org

Validated in 3 fungal species including Magnaporthe, the causal agent of rice blast that destroys enough rice to feed more than 60 million people every year.

🍾Big Congratulations to my dear colleague Uli Schaffrath @rwth.bsky.social and collaborators! Beautiful work showing that plant pathogenic fungi hijack phosphate signaling with conserved enzymatic effectors www.science.org/doi/10.1126/... #PlantSci #effectors #immunity #MolPlantPhys

Yes, that's a proteasome! Guess where it is....in the apoplast! Nice to see Richard Vierstra's work out! #PPStasis #proteostasis #proteasomes #PlantSci www.nature.com/articles/s41...

DELLA family proteins function beyond the GA pathway #plantscience

Our latest BioRxiv by @cmzammit.bsky.social, Cory Nadel, @pottslab.bsky.social on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to @amgen.bsky.social, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

‘The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance’ www.cell.com/immunity/abs...

Really cool work identifying RIOK3 as a Ubiquitin-binding factor for 40S ribosome degradation: www.cell.com/molecular-ce...

🚨 The #Ubiquitin Congress is back in Würzburg! 🚨 Excited to host it again, June 2-4, 2025! 🌟 ✨ Still time to submit your abstract for a Short Talk! 🗓️ Registration Deadline: March 1st 📝 Abstract Submission Deadline: April 15th Don’t miss out—register now! ➡️ www.ubiquitin-wuerzburg-2025.de

Join us in Vienna 8-9 May for the #Ubiquitin & Friends Symposium 2025! Excellent line-up of guest speakers👇And many slots for talks from abstracts, plus flash-talks & posters! Lots of opportunities to network with peers & experts in a friendly atmosphere! ➡️ www.protein-degradation.org/symposium/

Context is everything! (N-) #degron specificity of a #ubiquitin ligase reprogrammed under #proteotoxic stress. Interesting implications for biology, drug design and how we assess E3 specificity....

Been thinking about creating a collection of good protein structure figures, as inspiration for my own work. #1 www.nature.com/articles/s41...

Deep learning for proteins tutorial: github.com/Graylab/DL4P...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Open call for DAAD funded PhD students of our graduate school of biology and medicine @uni-freiburg.de Please apply, if you are interested in joining us or one of our fantastic colleagues! www.daad.de/en/studying-...

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage. Check it out here: www.nature.com/articles/s41...

Happy to see that our Cell wall integrity #CWI & #ATG8ylation #preprint found a home @natureplants www.nature.com/articles/s41... Congrats Jose, Peng, Alessia & everyone involved. Stay tuned for exciting updates on this story…

Cool model of polyubiquitin chain length dictating ribosome stall resolution rdcu.be/d8iMr #ribosome #RQC

Cells are filled with toxic stuff that damages healthy proteins. Is that garbage just left to rot on the curb? No way! Ubiquitin ligases have evolved to recognize chemical damage and clean it up! www.nature.com/articles/s41...

New in @plantphys.bsky.social - Destined for destruction: The role of methionine aminopeptidases and plant cysteine oxidases in N-degron formation academic.oup.com/plphys/article… from @emilyflashman.bsky.social @oscarlorenzos.bsky.social et al