(@diegoesposito.bsky.social)

First: our structure of SspH1, together with NMR and SAXS to understand the conformational dynamics of the protein in complex with ubiquitin and PKN1. Was great fun working with and learning from @diegoesposito.bsky.social www.biorxiv.org/content/10.1... (2/4)

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Conformational dynamics of the bacterial E3 ligase SspH1 The SspH/IpaH family of novel E3 ligases (NELs) are found in a number of Gram-negative bacteria and are used to target host enzymes for degradation to support pathogenesis. These E3 enzymes are autoin... https://www.biorxiv.org/content/10.1101/2025.05.12.653404v1