Very happy to share two back-to-back preprints of my postdoc work on bacterial NEL E3 ligases from my time in @katrinrittinger.bsky.social lab at @crick.ac.uk in collaboration with the ChemBio team at GSK (1/4)

After a great review process with @naturecomms.bsky.social, I'm so happy to share our work identifying inactive RING E3 #ubiquitin #pseudoligases in the TRIM protein family!! rdcu.be/ehlGW 🥳 🍾 🙌 @katmcphie.bsky.social @diegoesposito.bsky.social @katrinrittinger.bsky.social @crick.ac.uk

Great @chemrxiv.bsky.social preprint by a team of GSK around @jtbush.bsky.social. They showcase the power of single- and multi-step direct-to-biology approaches by developing a potent, cell-active actylamide inhibitor for WRN helicase. chemrxiv.org/engage/...

Interesting paper by the groups of @katrinrittinger.bsky.social and @jtbush.bsky.social in @commschem.bsky.social. DIA-based chemical proteomics in combination with direct-to-biology compound optimization identifies new, enantioselective inhibitors for the DUB OTUD7B. www.nature.com/articles/s42...

Happy to share our new paper, out now in @commschem.bsky.social. Was great working with Aini and @katmcphie.bsky.social on this! We used chemoproteomics and HTC to find an enantioselective hit for OTUD7B. www.nature.com/articles/s42... @katrinrittinger.bsky.social @jtbush.bsky.social @crick.ac.uk