Charlotte Zammit
@cmzammit.bsky.social
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Chemist/Chemical Biologist. Project Scientist @UCBerkeley. DPhil (University of Oxford)
reposted by
Charlotte Zammit
Dan Nomura
7 months ago
Our latest BioRxiv by
@cmzammit.bsky.social
, Cory Nadel,
@pottslab.bsky.social
on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to
@amgen.bsky.social
, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!
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Covalent Destabilizing Degrader of AR and AR-V7 in Androgen-Independent Prostate Cancer Cells
Androgen-independent prostate cancers, correlated with heightened aggressiveness and poor prognosis, are caused by mutations or deletions in the androgen receptor (AR) or expression of truncated varia...
https://www.biorxiv.org/content/10.1101/2025.02.12.637117v1
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