Gisela Otten has joined the Board of Directors and will Chair the Board of the Women’s team at Cambridge United Football Club. Gisela joined @felixrandow.bsky.social's group at the LMB in 2017 and spent 6 years playing for Cambridge United Women. #LMBAlumni www.cambridgeunited.com/news/mike-da...

Another insightful piece recently out @natsmb.nature.com delineating how Shigella utilises its effector IpaH1.4 to counteract host RNF213-induced LPS ubiquitylation. Very interesting work by the lab of @felixrandow.bsky.social. If you want to, have a go at it: www.nature.com/articles/s41...

How do cytosol-invading bacteria evade LPS ubiquitylation by the host's defence machinery? @felixrandow.bsky.social's group determined that Shigella flexneri uses IpaH1.4 to degrade the LPS ligase RNF213, inhibiting the cell's ubiquitylation abilities. Read more: tinyurl.com/3y4kv2bp #LMBResearch🧪

RNF213, a host E3 ligase, ubiquitylates LPS to mark cytosol-invading bacteria for autophagy. But how do cytosol-adapted bacteria escape? We found that Shigella's E3 ligase IpaH1.4 blocks LPS ubiquitylation by degrading RNF213 via the proteasome. www.nature.com/articles/s41...

Not long until the deadline for this faculty position @dunnschool.bsky.social... Are you the one to lead a group doing great research in a special environment, while teaching outstanding students? www.path.ox.ac.uk/vacancy/asso...

Exciting news: Registration for the 2025 UK Proteotasis & Autophagy meeting (3-5th June) is open: tinyurl.com/mr3p49f9

There are few moments more rewarding in running a lab than having a student defend their PhD thesis. Congratulations Dr. @marianapdc.bsky.social for this amazing achievement. And thanks to @lloydlab.bsky.social and Bart Lambrecht for being the examiners.

Congratulations to @lara-kruger.bsky.social, postdoc in @deriverylab.bsky.social in @cellbiol-mrclmb.bsky.social, who is leaving the LMB to establish her own research group at @institutcurie.bsky.social in Paris! Best of luck to you Lara! #LMBAlumni

How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR & NV shorturl.at/fImjA

Guess what? You got it, another @plosbiology.org focus issue of thought-provoking Perspectives and Essays on an issue relevant to this Keystone Symposium What can I say? We clearly care a lot about many of the topics at these joint meetings Take a look and let us know what you think! 👀⬇️ 🧪

We made it to 100! 📢💯 The #ubiquitin and #ubl Starter Pack now includes 100 profiles to follow if you’re interested in any aspect of the field: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology… Check out the list and let me know if you are missing.

By my reckoning, yesterday marked the 50th anniversary of ubiquitin's discovery! 🎈🎉🎁🥂 www.pnas.org/doi/10.1073/...

We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...

After lots of teasing by @npariente.bsky.social I updated my profile picture. No more impersonation of my younger self!

PhDs in biochemistry, structural biology, pharmacology, or similar, located in the US and with strong publication track records and a high motivation to solve Parkinson's, please send CV directly to me at [email protected]. Repost appreciated.

Real-time map from Surfers Against Sewage app. For those in blissful ignorance, this is what happens after normal heavy rains in Britain: huge swathes of UK coastline rendered unswimmable by water companies’ discharges. I know it’s old news but I refuse to become desensitized to the sheer awfulness

We found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇 www.nature.com/articles/s41...

As we go through various steps of the peer-review process, @gmivienna.bsky.social comms team put together a nice summary of our recent #preprints : www.oeaw.ac.at/gmi/detail/n... Thx @philippdexheimer.bsky.social for the illustration

On Jan 6 1912, Alfred Wegener presented his theory of continental drift and supercontinent Pangaea's breakup into today's continents. Despite initial rejection, modern seismology and ocean drilling in the 1950s/60s validated his ideas, leading to the current understanding of plate tectonics. ⚒🧪

Happy New Year! Let’s start with an updated starter pack. Now with 94 profiles to follow if you are interested in anything #ubiquitin or #Ubl: signalling, structure and biochemistry, biology, mechanisms, proteostasis, TPD, chemical biology, etc. Let me know if you or anyone else is missing.

Peptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab www.nature.com/articles/s41...

New paper out from Deretic’s lab!!! rupress.org/jcb/article/...

Today in A Coruña. It has become a nice tradition for us to visit their annual photo exhibition.

Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏

Exciting 3-year postdoc opportunity with @carter-lab.bsky.social within a programme aimed at identifying the links between microtubule motors and axonal cargos. Read more about the role here: www.nature.com/naturecareer... Apply by 30 DEC #ScienceJobs #CambridgeJobs #PostdocJobs #GenomeEngineering