Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social. https://doi:10.1111/febs.70259 The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com www.nature.com/articles/s41...

From MBoC... Dr. Francesco Scavone (Stanford) shows ATG9A has an unexpected role in trafficking K63-polyubiquitin–modified membrane proteins. Blocking the signal traps cargos in vesicle clusters; once released, they rapidly reach lysosomes. 🔗 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology

Absolutely honoured to see our work featured on this month’s cover! 🎉🧬 Artwork by the incredibly talented @doroteaartscience.bsky.social 👇

Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature. 👇 for @zaffagg3 's detailed explanation www.embopress.org/doi/full/10....

#cryoEM confluence in Munich #womeninSTEM

new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here www.biorxiv.org/content/10.1...

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...

Highlight on our recent work on UFMylation by @dimitristypas.bsky.social on @NatureSMB: www.nature.com/articles/s41...

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

We are excited to get on this project and learn more about chromatin organization! Great to share this good news with Ina and Matilde, congrats everyone!

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

Excited to present first publication from the Joshi lab, now in @jcb.org Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain. rupress.org/jcb/article/...

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology www.nature.com/articles/s41...

New paper from our lab! 🥳🎉 "UFMylation orchestrates spatiotemporal coordination of RQC at the ER" @Science Advances www.science.org/doi/10.1126/...

Happy to have contributed in a small way to this exciting study from Daniel Nomura identifying a new covalent degrader handle that acts through the dcaf16 E3 ligase! 🤩

We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin

Our PKA-autophagy story by outstanding graduate student Ashley Segura (co-led with Rose Citron) published in @embojournal.org, dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with @manciaslab.bsky.social!

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology rdcu.be/ehbaL

Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit www.pnas.org/doi/abs/10.1...

Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits academic.oup.com/nar/article/...

Check out our new preprint, in which brilliant @alessandrick.bsky.social‬ revealed a novel function of the RNA-binding protein IGF2BP3 in regulating the unfolded protein response. Please see the wonderful thread by @alessandrick.bsky.social‬ for more detail! www.biorxiv.org/content/10.1...

1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️ www.biorxiv.org/content/10.1...

doi.org/10.1515/hsz-... I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!

Happy to have contributed in a small way to this spectacular study from @aakritijain.bsky.social & @robzonculab.bsky.social identifying LyLAP as a protease for TM domains in the lysosome. Upregulated in PDAC, LyLAP safeguards lysosomes from membrane damage. www.science.org/doi/10.1126/...

Fantastic study out today by superstar postdoc @aakritijain.bsky.social! It identifies the unresolved function of LyLAP, a protein associated with poor prognosis in PDAC. It is not a phospholipase but a membrane protein protease! Happy that I could help through our untargeted lipidomics platform

Bryce Brownfield's review on the structural biology of Golgi trafficking has been published! authors.elsevier.com/a/1kqrY3PA3s... Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!

Super excited to share our latest work on deciphering the #Ubiquitin Code “𝗨𝗯𝗶𝗥𝗘𝗔𝗗 𝗱𝗲𝗰𝗶𝗽𝗵𝗲𝗿𝘀 𝗽𝗿𝗼𝘁𝗲𝗮𝘀𝗼𝗺𝗮𝗹 𝗱𝗲𝗴𝗿𝗮𝗱𝗮𝘁𝗶𝗼𝗻 𝗰𝗼𝗱𝗲 𝗼𝗳 𝗵𝗼𝗺𝗼𝘁𝘆𝗽𝗶𝗰 𝗮𝗻𝗱 𝗯𝗿𝗮𝗻𝗰𝗵𝗲𝗱 𝗞48 𝗮𝗻𝗱 𝗞63 𝘂𝗯𝗶𝗾𝘂𝗶𝘁𝗶𝗻 𝗰𝗵𝗮𝗶𝗻𝘀” @cp-molcell.bsky.social 1/8 www.cell.com/molecular-ce...

Check out this cover highlighting @amgen.bsky.social postdoc Kyle Mangano’s work on VIPER-TACs! 🐍

Excited to share our latest work with the fraaije.bsky.social (Groningen U) & Ram (Leiden U) groups on sorbicillinoid natural products in ACS Chem Bio! CRISPR-powered expression in A. niger boosts protein yields, and crystal structures reveal key catalytic mechanisms. pubs.acs.org/doi/10.1021/...

I wrote about the harmful impacts of NIH funding cuts on the health and economy of Indiana. www.indystar.com/story/opinio...

Excited to share our latest work! We found kinesin Kar3 is required for ER protein quality control. This 10-yr project involved 78 students, including undergrad & master's students in my lab & students enrolled in CURE I helped design, & 2 excellent colleagues. www.molbiolcell.org/doi/10.1091/...

Mitochondria a safe haven for aggregation-prone proteins? #neurodegeneration. #Parkinson. Find our latest manuscript in @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

DUBs - unsung yet exciting players in the UPS: kay hofmann et al reveal bacterial DUBs with irreversible clippase activity, reshaping our view on ubiquitin dynamics ... and providing a tool to distinguish Ub and ISG15 signals in immune signalling. chapeau! www.sciencedirect.com/science/arti...

Here is the link to the final version of our manuscript on K63-polyubiquitin and ATG9A in membrane trafficking.(molbiolcell.org/doi/10.1091/...)

Such a fun collaboration with @michaelnadbio.bsky.social! Check out the latest form of #ubiquitin modification- MARUbylation!

Our work on K63-polyubiquitin in membrane trafficking is out! Check out how we use a high affinity and specific sensor for K63-polyUb to identify K63-polyubiquitylated plasma membrane proteins in clusters of vesicles containing ATG9A. Link: www.molbiolcell.org/doi/10.1091/...

Autophagy UK & Proteostasis UK joint meeting -June 3-5. Exploring the lifecycle of cellular components from synthesis to degradation. Going to be a great meeting and we look forward to welcoming you to Dundee! Exciting lineup of speakers and opportunities for ECRs Register here: tinyurl.com/mr3p49f9

Really cool work identifying RIOK3 as a Ubiquitin-binding factor for 40S ribosome degradation: www.cell.com/molecular-ce...

Cool stuff from Andrey Klymchenko's lab. These plasma membrane labels are a pretty smart design. Check it out! pubs.acs.org/doi/10.1021/...

Open call! The EMBO Young Investigator Programme supports young group leaders in Europe and beyond. Apply by 1 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences 🧪

Wonderful work and so happy of being part of it

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

Dear #plantsci community, PLEASE HELP or RT! We are looking for a leaf specific promoter for a tissue specific CRISPR experiment in Arabidopsis. Any suggestions?

I couldn't dream of a better opportunity than helping bring good research to publication in the most respected cell biology journal 🙏🏻

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that. www.biorxiv.org/content/10.1...

Support the dedicated civil servants that keep our government running on Feb. 11 in DC actionnetwork.org/events/march...

Cool model of polyubiquitin chain length dictating ribosome stall resolution rdcu.be/d8iMr #ribosome #RQC

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...