New Online! The mechanistic basis and cellular functions of UFMylation

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social --https://biomed.news/bims-proteo/2025-11-30 Highlight: Defining the role of β-cell IRE1α/XBP1 and its gene regulatory network components in non-obese diabetic mice www.nature.com/articles/s41...

Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Secretome translation shaped by lysosomes and lunapark-marked ER junctions www.nature.com/articles/s41...

Cette année @csignaling.bsky.social et #Centre_Eugène_Marquis étaient présents à #La_Josselinaise_des_femmes -- 👏👏👏👏👏👏 Bravo à toutes les participantes et @celinephilippe.bsky.social #MattLeGallo #MyriamBontonou et MERCI du soutien!!!! @insermgrandouest.bsky.social @rennesuniv.bsky.social

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...

@csignaling.bsky.social était présent aux #5h_de_L_Yaigne_2025 aux côtés de #La_fée_Viviane (@fee -- MERCI AU SOUTIEN INCONDITIONNEL À LA RECHERCHE CONTRE LE CANCER DEPUIS 2011 !!!!!!!! @inserm.fr @insermgrandouest.bsky.social #Centre_Eugene_Marquis @rennesuniv.bsky.social

Cette année encore @csignaling.bsky.social était présent à #La_Vannetaise_Officielle -- 👏👏👏👏👏👏 Bravo à tous les participants et à @elodie-lafont.bsky.social #Matthieu_LeGallo #Manon_Nivet @insermgrandouest.bsky.social @inserm.fr @rennesuniv.bsky.social #centre_eugene_marquis

Such another great marathon of cell death science, this year in Berlin @ecdoorg.bsky.social Thanks to all organizers !

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

This week's very rich selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Predicting protein-protein interactions in the human proteome www.science.org/doi/10.1126/...

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social. https://doi:10.1111/febs.70259 The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor www.nature.com/articles/s41... @natimmunol.nature.com @aarhusuniint.bsky.social

@biorxivpreprint.bsky.social Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing @stanforduniversity.bsky.social @lecong.bsky.social @sciencebyravi.bsky.social www.biorxiv.org/content/10.1...

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation www.sciencedirect.com/science/arti...

"We propose a model in which TF binding is not determined by individual binding sites, but rather by the sum of multiple, overlapping binding sites." www.nature.com/articles/s41...

Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @cp-immunity.bsky.social www.cell.com/immunity/ful...

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences www.nature.com/articles/s42...

Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier @cp-immunity.bsky.social @gpasp.bsky.social www.cell.com/immunity/ful...

Delighted to share our latest collaborative work with Santosh Chauhan's group at CCMB, Hyderabad, out now in @embojournal.org We use the Drosophila hematopoietic progenitors in this study to investigate pro-self-renewal mechanisms! Congrats to all the authors! www.embopress.org/doi/full/10....

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation. www.nature.com/articles/s41...

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy www.nature.com/articles/s41...

#ER_literature ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis: Developmental Cell www.cell.com/developmenta...

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social bit.ly/47b3Mjk

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

STING drives #necroptosis, and here’s how it does it! Congratulations to @gianmaria-liccardi.bsky.social and his amazing team! www.nature.com/articles/s41...

Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body #JBC www.jbc.org/article/S002...

‘Humoral determinants of checkpoint immunotherapy’ www.nature.com/articles/s41...

This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... 🗣️: 4 #preprints from @qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025...

@csignaling.bsky.social Bravo @elodie-lafont.bsky.social et #Remy_Pedeux pour l'obtention des financements ANR PRC - Secret-dit et promote-ASO @agencerecherche.bsky.social #2025 @insermgrandouest.bsky.social @inserm.fr @rennesuniv.bsky.social

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS www.pnas.org/doi/10.1073/...

#ER_literature The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD www.biorxiv.org/content/10.1...

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Design and Application of Cereblon-Recruiting Prodegraders pubs.acs.org/doi/10.1021/...

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

This week's selection of articles and #prerints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: External strain on the plasma membrane is relayed to the ER by membrane contact sites and alters cellular energetics www.science.org/doi/10.1126/...

RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

ICYMI: New Online! Key challenges and recommendations for defining organelle membrane contact sites

www.nature.com/articles/s41... 🧪

Nerve-to-cancer transfer of mitochondria during cancer metastasis www.nature.com/articles/s41...

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint! www.biorxiv.org/content/10.1...

1/2 The new impact factor numbers are out. No sane person should use them as a proxy for anything, multiple organizations and institutes signed DORA, and still many people rely on them: I'll make it short and sweet: everything that carries "Nature" in its title went up. Sometimes crazily so -->

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Welcome to @celinephilippe.bsky.social in our unit @csignaling.bsky.social who is officially hired as @inserm.fr CRCN. Her projects will explore the connections between #ER_proteostasis and #RNA_metabolism in #Cancer --- BRAVO Céline !!!!!!

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: In-Cell Approach to Evaluate E3 Ligases for Use in Targeted Protein Degradation -- pubs.acs.org/doi/10.1021/...