This project started with confusion 🤔 www.nature.com/articles/s41... Loss of LUBAC or OTULIN causes severe inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic manifestations come from?

New Online! The mechanistic basis and cellular functions of UFMylation

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social --https://biomed.news/bims-proteo/2025-11-30 Highlight: Defining the role of β-cell IRE1α/XBP1 and its gene regulatory network components in non-obese diabetic mice www.nature.com/articles/s41...

Delayed weekly selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight - Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response academic.oup.com/nar/article/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Secretome translation shaped by lysosomes and lunapark-marked ER junctions www.nature.com/articles/s41...

Cette année @csignaling.bsky.social et #Centre_Eugène_Marquis étaient présents à #La_Josselinaise_des_femmes -- 👏👏👏👏👏👏 Bravo à toutes les participantes et @celinephilippe.bsky.social #MattLeGallo #MyriamBontonou et MERCI du soutien!!!! @insermgrandouest.bsky.social @rennesuniv.bsky.social

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... highlight: Role of AAA-ATPase Cdc48p in peroxisomal quality control www.cell.com/cell-reports...

@csignaling.bsky.social était présent aux #5h_de_L_Yaigne_2025 aux côtés de #La_fée_Viviane (@fee -- MERCI AU SOUTIEN INCONDITIONNEL À LA RECHERCHE CONTRE LE CANCER DEPUIS 2011 !!!!!!!! @inserm.fr @insermgrandouest.bsky.social #Centre_Eugene_Marquis @rennesuniv.bsky.social

Cette année encore @csignaling.bsky.social était présent à #La_Vannetaise_Officielle -- 👏👏👏👏👏👏 Bravo à tous les participants et à @elodie-lafont.bsky.social #Matthieu_LeGallo #Manon_Nivet @insermgrandouest.bsky.social @inserm.fr @rennesuniv.bsky.social #centre_eugene_marquis

Such another great marathon of cell death science, this year in Berlin @ecdoorg.bsky.social Thanks to all organizers !

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

This week's very rich selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Predicting protein-protein interactions in the human proteome www.science.org/doi/10.1126/...

The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46

Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social. https://doi:10.1111/febs.70259 The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR

STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor www.nature.com/articles/s41... @natimmunol.nature.com @aarhusuniint.bsky.social

@biorxivpreprint.bsky.social Surfaceome CRISPR activation screening uncovers ligands regulating tumor sensitivity to NK cell killing @stanforduniversity.bsky.social @lecong.bsky.social @sciencebyravi.bsky.social www.biorxiv.org/content/10.1...

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: α-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation www.sciencedirect.com/science/arti...

"We propose a model in which TF binding is not determined by individual binding sites, but rather by the sum of multiple, overlapping binding sites." www.nature.com/articles/s41...

Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @cp-immunity.bsky.social www.cell.com/immunity/ful...

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences www.nature.com/articles/s42...

Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier @cp-immunity.bsky.social @gpasp.bsky.social www.cell.com/immunity/ful...

Delighted to share our latest collaborative work with Santosh Chauhan's group at CCMB, Hyderabad, out now in @embojournal.org We use the Drosophila hematopoietic progenitors in this study to investigate pro-self-renewal mechanisms! Congrats to all the authors! www.embopress.org/doi/full/10....

A new paper reports direct ubiquitination of a small molecule BRD1732 in cells. BR31732 ubiquitination is E3 ligase-dependent and leads to inhibition of proteasomal degradation. www.nature.com/articles/s41...

Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy www.nature.com/articles/s41...

#ER_literature ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis: Developmental Cell www.cell.com/developmenta...

💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social bit.ly/47b3Mjk

I am beyond excited and incredibly proud to share that our work is now out in @nature.com This discovery was made possible thanks to the first author Kostas kelepouras, my fantastic lab , and the unique research environment here in Cologne in collaboration with the Hospital bambino Gesu in Rome.

STING drives #necroptosis, and here’s how it does it! Congratulations to @gianmaria-liccardi.bsky.social and his amazing team! www.nature.com/articles/s41...

Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: PERK and IRE1α promote exosome secretion via blocking lysosomal degradation of multiple vesicular body #JBC www.jbc.org/article/S002...

‘Humoral determinants of checkpoint immunotherapy’ www.nature.com/articles/s41...

This week's selection of #preprints and articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... 🗣️: 4 #preprints from @qilabuva.bsky.social lab on SEL1L-HRD1 in ERAD doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025... doi.org/10.1101/2025...

@csignaling.bsky.social Bravo @elodie-lafont.bsky.social et #Remy_Pedeux pour l'obtention des financements ANR PRC - Secret-dit et promote-ASO @agencerecherche.bsky.social #2025 @insermgrandouest.bsky.social @inserm.fr @rennesuniv.bsky.social

Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH–dependent exocytosis of GOLIM4 | PNAS www.pnas.org/doi/10.1073/...

#ER_literature The involvement of the ER-phagy receptor FAM134B in membrane contact sites between ER and endolysosomes promotes ERLAD www.biorxiv.org/content/10.1...

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Design and Application of Cereblon-Recruiting Prodegraders pubs.acs.org/doi/10.1021/...

The E3 ligase Parkin ubiquitinates many proteins. Koszela, Walden (@hw1o9.bsky.social) et al. @uofglasgow.bsky.social‬ identify and biochemically validate a direct Parkin interaction with a substrate, Miro1. rupress.org/jcb/article/...

This week's selection of articles and #prerints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: External strain on the plasma membrane is relayed to the ER by membrane contact sites and alters cellular energetics www.science.org/doi/10.1126/...

RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...

ICYMI: New Online! Key challenges and recommendations for defining organelle membrane contact sites

www.nature.com/articles/s41... 🧪

Nerve-to-cancer transfer of mitochondria during cancer metastasis www.nature.com/articles/s41...

How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint! www.biorxiv.org/content/10.1...

1/2 The new impact factor numbers are out. No sane person should use them as a proxy for anything, multiple organizations and institutes signed DORA, and still many people rely on them: I'll make it short and sweet: everything that carries "Nature" in its title went up. Sometimes crazily so -->

This week's selection of articles on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Activation of macrophages engulfing neutrophils by TNF switches efferocytosis to caspase-8–mediated pyroptosis and IL-1β production @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Welcome to @celinephilippe.bsky.social in our unit @csignaling.bsky.social who is officially hired as @inserm.fr CRCN. Her projects will explore the connections between #ER_proteostasis and #RNA_metabolism in #Cancer --- BRAVO Céline !!!!!!