Andreas Linkermann
@linkermannlab.bsky.social
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š„ 149
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Chair 5th Med Dept UMM, Heidelberg University Kidney Transplantation and Cell Death Biology
pinned post!
Happy to start at Bluesky with a post on our recent manuscript at
@nature.com
:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as
@theprattgroup.bsky.social
,
@fedorovalab.bsky.social
and many who do not (yet) have a Bluesky account.
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Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17Ī²-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
https://www.nature.com/articles/s41586-025-09389-x
8 months ago
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reposted by
Andreas Linkermann
James Olzmann
3 months ago
Thrilled to have contributed to this work led by
@jgcastillo.bsky.social
during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis.
www.science.org/doi/10.1126/...
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Selective disruption of lipid peroxide homeostasis in intratumoral regulatory T cells by targeting FSP1 enhances cancer immunity
Deletion of Aifm2 disrupts Treg cell immunosuppression within tumors without inciting autoimmune pathology in mice.
https://www.science.org/doi/10.1126/sciadv.aea3703
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Reviewing the paper by the KatsĀ“ lab published today in
#Cell
, "Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia", I learned that cuproptosis is real! Here is my preview: When heme is low, copper kills cancer:
www.cell.com/cell/fulltex...
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When heme is low, copper kills cancer
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respirat...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901423-0
3 months ago
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Here is a link to our most recent editorial for
#CDDiff
, Cell Death and Differentiation. ItĀ“s on work by Tony Letai and team.
www.nature.com/articles/s41...
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What does not kill you makes you Weaker! - Cell Death & Differentiation
Tumor cell evasion from regulated cell death is a hallmark of cancer [1]. Davern et al. now identify resistance to mitochondrial apoptosis to represent the common mechanism by which persister cells th...
https://www.nature.com/articles/s41418-025-01658-6
3 months ago
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reposted by
Andreas Linkermann
Nature
4 months ago
Nature research paper: Erythropoietin receptor on cDC1s dictates immune tolerance
go.nature.com/496nEob
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Erythropoietin receptor on cDC1s dictates immune tolerance - Nature
The tolerogenic activityĀ of type 1 conventional dendritic cells (cDC1s) is determined by EPOR, which is preferentially expressed in cDC1s and inducesĀ antigen-specificĀ FOXP3-expressing regulatory T cells.
https://go.nature.com/496nEob
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reposted by
Andreas Linkermann
Nature
5 months ago
Obituary: David Baltimore (1938-2025) virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
go.nature.com/443Vojo
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David Baltimore obituary: virologist whose enzyme discovery transformed understanding of cancer and HIV/AIDS
The protein, reverse transcriptase, has become an essential tool for making DNA copies of RNA.
https://go.nature.com/443Vojo
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Secondary Necrosis Following CaspaseāActivation can Occur Independently of Gasdermin E - Gavali - Advanced Science - Wiley Online Library
advanced.onlinelibrary.wiley.com/doi/10.1002/...
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Secondary Necrosis Following CaspaseāActivation can Occur Independently of Gasdermin E
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202507381
6 months ago
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Congrats to the wonderful Sid Balachandran and team!
www.nature.com/articles/s41...
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Host cell Z-RNAs activate ZBP1 during virus infections - Nature
Nature - Host cell Z-RNAs activate ZBP1 during virus infections
https://www.nature.com/articles/s41586-025-09705-5
6 months ago
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reposted by
Andreas Linkermann
Molecular Medicine Partnership Unit
7 months ago
Registration is open: register for the first
#MMPUResearchDay
taking place in
#Mannheim
at
#CubexOne
on Oct 13, 2025. A great line-up of scientists from
#MMPU
,
#EMBL
,
#UMM
,
#UKHD
.
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Very pleased to share this "spotlight" in Trends in Endocrinology and Metabolism which refers to our recent work.
www.sciencedirect.com/science/arti...
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Hydroxyestradiol alleviates acute kidney injury via blockade of ferroptosis
The molecular mechanisms underlying sex differences in acute kidney injury (AKI) remain incompletely understood. In a study recently published in Natuā¦
https://www.sciencedirect.com/science/article/abs/pii/S1043276025001936
7 months ago
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Here is a "highlight" on our recent work written by Boyi Gan for Cell Death and Differentiation:
www.nature.com/articles/s41...
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Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury - Cell Death & Differentiation
Cell Death & Differentiation - Oestradiol-mediated ferroptosis defense shapes sex differences in acute kidney injury
https://www.nature.com/articles/s41418-025-01573-w
8 months ago
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www.aerzteblatt.de/news/warum-f...
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Warum Frauen seltener ein akutes Nierenversagen erleiden ā Deutsches Ćrzteblatt
https://www.aerzteblatt.de/news/warum-frauen-seltener-ein-akutes-nierenversagen-erleiden-a027d07e-8183-42a3-940e-07f0837d97fe
8 months ago
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This refers to our recent manuscript. Estrogen-powered kidney protection | Science Signaling
www.science.org/doi/10.1126/...
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Estrogen-powered kidney protection
Estrogen protects against kidney injury through both genomic and nongenomic mechanisms.
https://www.science.org/doi/10.1126/scisignal.aeb6175
8 months ago
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STING drives
#necroptosis
, and hereās how it does it! Congratulations to
@gianmaria-liccardi.bsky.social
and his amazing team!
www.nature.com/articles/s41...
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STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD - Nature
Nature - STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
https://www.nature.com/articles/s41586-025-09536-4
8 months ago
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Happy to start at Bluesky with a post on our recent manuscript at
@nature.com
:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as
@theprattgroup.bsky.social
,
@fedorovalab.bsky.social
and many who do not (yet) have a Bluesky account.
loading . . .
Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17Ī²-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
https://www.nature.com/articles/s41586-025-09389-x
8 months ago
4
36
17
reposted by
Andreas Linkermann
Ubellacker Lab
8 months ago
Hot off the presses! Was an honor to team up with Scott Dixon
@stanforduniversity.bsky.social
on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic.
rdcu.be/eBbqV
add a skeleton here at some point
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