new out in Nature, targeting FSP1 to trigger ferroptosis www.nature.com/articles/s41... www.nature.com/articles/s41...

Please read more about this publication in this article in the Harvard Newsletter: Triggering cell death in metastatic melanoma may pave the way for new cancer treatments

Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.

Excited to share my postdoctoral work, out today in Nature! www.nature.com/articles/s41... We discovered that melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits melanoma progression.

Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1 www.nature.com/articles/s41...

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Fantastic lymph node protocols from @retickerflynn.bsky.social Lab, Cort Breuer, and team. Check it out!

Interested in studying lymph node metastasis? Check out our protocol by Cort Breuer out today in @natprot.nature.com bsky.app/profile/nat...

New Article! Spontaneous and experimental models of lymph node metastasis

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1

Join me in Boston October 6th for a 1-day conference on #mappingbiology to transform #cancertherapeutics. Register by September 25th to benefit from the complimentary (free) admission! Topics, speakers, and talk opportunities here: abcam.me/mappingbiolo... @abcamofficial.bsky.social

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice. www.nature.com/articles/s42...

Huge thank you to @olzmannlab.bsky.social and Scott Dixon for a phenomenal 1st FASEB Ferroptosis conference! I’m grateful to be part of such a collaborative community and it was especially great to meet all the brilliant trainees whose insights are clearly shaping the exciting future of the field! 🎉

New preprint w/ the Dupage lab led by @jgcastillo.bsky.social! FSP1 KO in Tregs / Tcells promotes tumor suppression, highlighting the therapeutic value potential of FSP1 inhibition. New paradigm for targeting ferroptosis in immune system (not just in cancer cells). 🤩 www.biorxiv.org/content/10.1...

It’s over 100°F in Boston, and though both the weather and funding climates are intense, we took a well-deserved ice cream break to celebrate the progress, and the incredible people past and present, behind it all. Happy 3rd birthday, ULab! 🎉

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

Join us next Monday: June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)!

Harvard Chan scientists participate in a rigorous application process for federal grants to conduct their vital health research. The government has now terminated nearly every single one of those grants.

Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.

Way-to-go Alanis Carmona and Lewis Hendrianto for your incredible posters today at the Landry Cancer Biology Consortium, and shout-out to Alanis on your Karin Grunebaum Cancer Research Foundation Rising Young Scientist Award!

Join us June 2, 3-4PM off the Harvard Longwood Quad for two great cell death discussions on ferroptosis in breast cancer metastasis from @mariesabatier.bsky.social (Ubellacker Lab) and on thiol-reductive stress from Maolin Ge (Bar-Peled Lab)

Fantastic visit yesterday from the great Scott Dixon as part of our Cutter Distinguished Lecture on Molecular Metabolism series. An honor to host such an outstanding scientist and mentor to so many in the cell death field!

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

and the News & Views www.nature.com/articles/d41...

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm

Can't wait for this fantastic meeting! See you all there - registration deadline June 1. Check it out and join us there today at shorturl.at/QA6T1

#FOLSCR is a new conference exploring all aspects of a form of cell death that results from iron accumulation and lipid peroxidation. Hear keynotes @ginadenicola.bsky.social and @brentstockwell.bsky.social with organizers Scott Dixon and @olzmannlab.bsky.social. Save your space: buff.ly/MmJsYQq

A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm

Short on time wrangling research hurdles or just life in general? @mariopalma.bsky.social and @mariesabatier.bsky.social have you covered with this focused spotlight on Ueda et al.’s work in Nature Cell Biology on oxidative niches and cancer cell dissemination. Spotlight article here: rb.gy/zi8wj9

Important walkthrough for newcomers in the field rdcu.be/eg58p

Our lab has an opening for a new Research Assistant (LSRP) starting this Summer/Fall. If you're interested in joining a vibrant community working at the interfaces of cancer metastasis and adaptive immunity, apply here: careersearch.stanford.edu/jobs/life-sc...

We’re proud Samir Mitri, Clinical Research Fellow with Ted James, MD and the Ubellacker Lab at @met-hsph.bsky.social, matched into Surgery at BIDMC! Samir led a collaboration combining clinical lymph node studies with metabolomics, funded by the Ludwig Center at Harvard. Congratulations, Samir!

See you there! Monday April 7th at 3PM on the Harvard Med Quad. bostoncelldeath.org

With support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world. Here are just three examples: hsph.harvard.edu/news/federal...

Join us for 2 great cell death discussions, Monday, March 3rd at 3PM on the Harvard Med Quad.! bostoncelldeath.org

Can't wait for this fantastic meeting! Join us there, registration is open now! 🤩

We’re hiring a #postdoc! The Dibble Lab at Harvard Medical School and Beth Israel Deaconess Medical Center in Boston studies the regulatory relationship between #signaling and #metabolic pathways. Email me at [email protected] !

See you at the next BCDI discussion Monday Feb 3rd at 3PM on the Harvard Med Quad (Goldenson 122)!

One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...

A huge thank you to all the authors and the @ubellackerlab.bsky.social for their incredible work and dedication! 👌

Congrats to mariesabatier.bsky.social, a postdoc in the ubellackerlab.bsky.social, for developing a comprehensive step-by-step protocol for lymph collection and isolation in mouse models out today in natprot.bsky.social. We hope this resource will prove useful to the field! rdcu.be/d5BjC

➡️Join our next BCDI meeting for not-to-be-missed discussions on harnessing GSDMD-mediated cell death in cancer immunotherapy from Hao Wu's lab and neutrophil-derived vesicles from Hongbo Lou's lab. Monday Jan 6th at 3PM on the Harvard Med Quad. bostoncelldeath.org

Come join us for the first 2025 meeting of BCDI! Jan 6th 3-4pm, Goldenson 122 off the Harvard Quad

I have initiated this #StarterPack with #RedoxBio researchers. Feel free to suggest other users, or yourself, to be included! go.bsky.app/UoVRtXp

Happy Thanksgiving from our lab to yours! Apple pie credit: @Midori Flores, PhD candidate extraordinaire 🤩

Fantastic opportunity for those looking to do a postdoc in cell death in cancer, and more!