Is there a convergent mechanism for triggering PINK1-Parkin-dependent mitophagy? Derek Narendra and coworkers find that diverse forms of mitochondrial damage are all sensed by a loss of mitochondrial membrane potential (MMP) www.embopress.org/doi/full/10....

It’s not hard to read this and see this as a blue print for what they want to do for all federal granting institutions, including the NIH

🚨🚨 @jenna-m-norton.bsky.social is a force. Her voice carries power, truth, and courage—threats to the regime. The only thing authoritarians fear more than a voice they cannot control is a chorus. So let’s give them one: speak up, speak loudly, and don’t stop. Stand with Jenna. ✊🇺🇸

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...

Trump’s HHS put me on “non-disciplinary” admin leave today. This was retaliation for speaking up. Moves like this are designed to silence us. Let’s not let. www.tiktok.com/t/ZP8Dteoop/

NEW: Jenna Norton, an NIH employee who is openly critical of Trump & RFK Jr, has been put on "non-disciplinary" administrative leave. She says the administration is trying to "scare and silence me." An HHS official, asked to comment, called her a radical leftist. www.nytimes.com/2025/11/13/u...

An remarkable new undergraduate course conceived and taught by our amazing colleague and Dean of Science Jeff Lichtman: "Genuinely Hard Problems" I wish I was an undergrad again!... 🤣🧪🧬🧠 @harvardmcb.bsky.social @harvardbrainsci.bsky.social @harvard.edu news.harvard.edu/gazette/stor...

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

We are in the midst of an all-out attempt to exclude the global majority from science. Watson was clear about where he fell on that. I would trade every single dinner, meeting, seminar, fancy campus, and prestigious donor for my incredible friends to be safer. Their science is worth far more.

Jeremy, I have followed your science advocacy on this platform with respect, but I find this thread deeply hurtful and sad and I am going to tell you why. While my wife did her postdoc at CSHL, she and our many dear friends had to endure the racist rhetoric of this man, which did constant harm

A new, nerdy paper. We figured out (some) of the rules underlying cell-permeability of probes and designed ligands that light up, grab, and move proteins around. Awesome @hhmijanelia.bsky.social x @uwmadison.bsky.social x @stjuderesearch.bsky.social collaboration! www.pnas.org/doi/10.1073/...

The cut rate labor business of grant funded academic science revealed in one tweet.

Dear all, A scientist from UNC Chapel Hill, Paul Maddox, is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign #Standupforscience secure.actblue.com/donate/paul-...

Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...

IT'S ALMOST HERE!! #NoKingsDay is around the corner. Gonna be a BIG event at @nihvigils.bsky.social and @27unihted.bsky.social We're going to play TWO SETS - one at the beginning and one at the end. #fucktrump #punk #punkrock #resist #FightFascism #AntiAuthoritarian #FuckICE #FightTheNazis

I don’t know who needs to hear this but the CDC is being eviscerated right now. America is not going to have any kind of outbreak response capacity after tonight. Americans’ health data is no longer secure. Say goodbye to federal public health in any capacity. It’s a disaster. We won’t recover.

NO TO ILLEGAL RIFS TRUMP AND VOUGHT ARE HURTING AMERICA Gather at the Office of Management and Budget (near WH, exact location to come) Monday, October 13, 2pm DM us if you were RIFed (or had coworkers who were RIFed) and would like to speak

Amazing

Some federal workers support the government shutdown, even as President Trump threatens to use this moment to lay off employees and cut funding to programs.

I signed @uthealthhouston.bsky.social alum! Are you an alum outraged by Trump's attacks on universities? Defend your school now by signing this alumni petition in support of these 9 universities as well as campus communities across America. alumni.controlshift.app/petitions/tr...

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

That’s a lot of science we left on the table.

Being Ready to Lose Well, Perseverance and How Not to Be Lost talkingpointsmemo.com/edblog/being...

This is sort of a classic prisoners' dilemma: If nobody defects, nobody has "priority". Which makes it essential that universities coordinate a united front.

This is extortion. Faculty, students, staff, alumni across the country need to get to their Presidents & Trustees today. Just say no. This blackmail only works if most everyone folds. Capitulation now means the end of American higher education for a generation. www.nytimes.com/2025/10/02/u...

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

BREAKING: WE WON!!! 💥 💥 💥 Federal Judge William G. Young ruled today in our lawsuit against the Trump administration that the policy of arresting, detaining, & deporting noncitizen students & faculty members for their pro-Palestinian advocacy violates the 1st Amendment. Full ruling here:

More than 5,000 federal workers (current and former) have now signed this letter urging "Congress to pass nothing less than a continuing resolution (CR) that reasserts Congress's constitutional powers, upholds our democracy and protects the American people."

This is absolutely ridiculous, would devastate numerous academic fields, and would destroy the lives of people I love very much. Please, please join me in sending a comment in on this telling them so

FUN (@fedworkersunited.bsky.social) is calling out the OMB memo threatening mass layoffs as a pressure tactic to get Congress to keep the federal government open. Read the release: www.federalunionists.net/press/statem...

The end of FY 2025 is coming, and #OMB appears perfectly content to use us as targets. We are not their chess pieces. We serve our PIs. We are here in our personal capacities. Follow the #NIH.

In @jcb.org, @lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...

If the GOP can't get the GOP to come up with a funding plan that the GOP will support, they're going to fire...... federal rank and file.

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Wow. This administration really must be afraid of a shutdown to make these threats. @schumer.senate.gov - You have the power to restore some semblance of balance to government. You mustn't squander it. #fightingcr If you don't, Vought will fire everyone anyway. 🤷🏻‍♀️ www.politico.com/news/2025/09...

Beyond proud of my federal colleagues who continue to risk their careers by speaking up about the waste, fraud and abuse from the Trump admin. Thanks to the brave heroes at VHA! actionnetwork.org/petitions/li... lincolndeclaration.org

It is extremely disingenuous to compare this to prior shutdown negotiations. This isn’t mere policy debate. This isn’t Dems “spoiling for a fight, damn the consequences.” This is the fight of our lives to save our democracy and shutdown authoritarianism. www.politico.com/news/2025/09...

The AAUP & @aft.org are fighting back to remind our elected leaders that higher education & public health research are transformative public goods. We must keep life-saving NIH research fully funded & stop the Trump admin’s devastating funding cuts that are halting medical breakthroughs.

Check out our trip to Capitol Hill yesterday with @fedsagainstdoge.bsky.social and @safa-science.bsky.social -- and sign the petition at bit.ly/FIGHTINGCR. It's up to 2️⃣5️⃣0️⃣0️⃣ signers! #FightingCR

Which is why we were on the Hill today and dropped off this letter to your office. We are urging Congress to pass a continuing resolution that protects the American people and stops executive overreach! actionnetwork.org/forms/civil-...

🇺🇸 Fed workers across the government are issuing a challenge to Congress: "We call on you to pass nothing less than a fighting CR: a funding bill that not only keeps the lights on, but that also includes statutory protections to rein in executive lawlessness." ✍️ Sign the letter. Spread the word 🔥

Sharing stories matters. If you’ve faced grant terminations, funding delays, loss of research jobs, etc., your voice is needed. Help show the real impact of NIH funding interference - tell your story so we don’t lose innovation, cures, and hope for the future. www.27unihted.org/biohealthbeats

My essay on the need for Mutual Academic Defense Compacts (MADCs) in this moment is now up in @aaup.org's @academemagazine.bsky.social, and will appear in print in the Fall issue. Please give it a read and share! #MADC www.aaup.org/mutual-defen...

"Increasingly, I wonder whether we will be able to do science here in the future." NIH employees I heard from say things are very grim over there, but they welcome the push for a "fighting CR" to rein Trump in — or a government shutdown if not.

Hey @schumer.senate.gov, ready to stand up and fight for what your constituents want? Your constituents want a healthy, safe, and technologically advanced society. Fight for it. Do the job you were hired for, and fight for what you know is right

I am a fed worker and it’s time to stand up together and FIGHT. Dems - do what needs to be done #fightingCR or #shutitdown. We have your back. @schumer.senate.gov #nocapitulation

This is not a normal time and it calls for strong actions. Schumer and Senate Democrats must fight for a budget bill that stops Trump, and be willing to accept a shutdown if Republicans refuse. New post from us summarizing the state of play. 1/

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

“The fight for science and universities is, at its core, a fight for democracy itself. Lose one, and you will lose the other.”