Organellophagy receptors display cytoplasmic intrinsically disordered regions (IDRS). The IDRs of ER-phagy and mitophagy receptors are interchangeable, required and sufficient for ER and mitochondria fragmentation that precedes lysosomal clearance of the organelle’s portions. rdcu.be/eF5DR

An interesting study from the ETH-Zurich ethz.ch/en/news-and-...

Come join us @science.org. We’re looking for a new editor to look after infectious disease and microbiome submissions. Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

From Switzerland to Portugal … and back. 🤔

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation. bit.ly/4fLWe99

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

@olzmannlab.bsky.social @tgalli.bsky.social @demangelab.bsky.social @agostinislab.bsky.social @abdourachidthiam.bsky.social @molinarilab-er.bsky.social @hennelab.bsky.social @jdejuan-sanz.bsky.social

🚨 Job alert We’re looking for a communications manager for the LifeArc Rare Respiratory Disease Centre. Deadline for applications 1st August @lifearc.bsky.social elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...

Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors. www.biorxiv.org/content/10.1...

We've just posted a new preprint: "A GCN1-independent activator of the kinase GCN2"

Excellent opportunity for interdisciplinary scientists. Please repost... www.linkedin.com/posts/instit...

I would like to warmly thank the ALPHA-1 Foundation for the important support allocated to our research project “Understanding the Molecular Mechanisms of Lysosomal Clearance of ATZ Polymers". A1F recognizes 2025 Grant Award Recipients during ATS alpha1.org/a1f-recogniz...

Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social

What a terrific FASEB ER meeting! Exceptional science and community! ❤️ Plus we got to see sea turtles nesting on the beach and a spaceX rocket launch! Cool!

Early morning discussion about see turtles with Jeff Brodsky. FASEB Endoplasmic Reticulum meeting, Melbourne, Florida. @faseborg.bsky.social

Ilaria Fregno from @molinarilab-er.bsky.social is studying the client specific ER-to-Lysosome-Associated Degradation pathways that are engaged by large misfolded proteins (e.g., Serpins polymers, pro-collagen variants and many others) that fail to enter ERAD.

Somatic escape variants of alpha1 antitrypsin. Great presentation by Lily Wu @profmarciniak.bsky.social

Here we are.

Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing. N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology www.nature.com/articles/s41...

📣 🥳 🧑‍💻 Our department is hiring: Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark Deadline June 1st Thanks for sharing! mbg.au.dk/en/news-and-...

For Dan! sites.google.com/umass.edu/da...

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Two structurally targeted allosteric regulators of GCase folding promote lysosomal transport of disease-causing variants, reduce ER stress and rescue lysosomal functions. Therapeutic potential for GD, PD, and Dementia with LB. mdpi.com/3299382 #mdpiijms via @IJMS_MDPI

Uncovering ERLAD: the ER-to-Lysosome Associated Degradation of large, aggregated, disease-causing, nasty misfolded proteins that fail to enter proteasomal-driven ERAD pathways. eur02.safelinks.protection.outlook.com?url=https%3A...

Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇 www.ntu.edu.sg/science/rese...

🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast! Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social #FASEB2025 #ERSRC

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

Look at the table if you wish to become a healthy old man/woman/…. It’s from today’s Nature Medicine by A.-J. Tessier et al. Optimal dietary patterns for healthy aging. Hopefully somebody will soon publish conflicting results proving that beer is not that bad, after all.

Don't miss the chance to present at the FASEB Endoplasmic Reticulum conference. This year's #ERSRC features @annebertolott.bsky.social as EMBO Keynote Speaker with organizers Julie Hollien and @gthibault.bsky.social. Submit your abstract by April 13 and register: events.faseb.org/endoplasmic-...

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

1, 2, 3!