Agostinis Lab
@agostinislab.bsky.social
📤 679
📥 493
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Laboratory of Cell Death Research and Therapy at VIB-KU Leuven Center for Cancer Biology (Belgium)
Do melanoma cells rewire interorganelle iron flow? ⚡️We found that BDH2 controls lysosome-to-mitochondria Fe2+ transport, coupling lysosomal pH to ferroptosis vulnerability. Huge congrats to
@francirizz.bsky.social
, thanks to
@juliebonnereau.bsky.social
and collabs 🙏
www.nature.com/articles/s42...
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BDH2-driven lysosome-to-mitochondria iron transfer shapes ferroptosis vulnerability of the melanoma cell states - Nature Metabolism
Rizzollo et al. show that BDH2 participates in iron distribution between cellular compartments, which sets the threshold for the ferroptosis vulnerability of the melanoma cell phenotypes, ultimately a...
https://www.nature.com/articles/s42255-025-01352-4
about 2 months ago
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Looking forward to giving a lecture at the 5th
#Endoplasmic
#Reticulum
International Symposium of
@inserm.fr
in Paris!
2 months ago
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📢 Only 2 Weeks Left for Early Registration! The early registration deadline for ECDO-2025
@ecdoorg.bsky.social
is fast approaching — July 7th is just around the corner! Fantastic program and speaker lineup, you cannot miss it!
www.ecdo.eu/ecdo2025/
#ECDO
#CellDeathResearch
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ECDO 2025
https://www.ecdo.eu/ecdo2025/
5 months ago
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reposted by
Agostinis Lab
Pedro Friedmann Angeli
5 months ago
Organelle conversations drive ferroptosis - news and views on a recent study by
@mariamls.bsky.social
and colleagues
www.nature.com/articles/s41...
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Organelle conversations drive ferroptosis - Nature Cell Biology
Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain....
https://www.nature.com/articles/s41556-025-01694-x
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Honored to have our image
@mariamls.bsky.social
featured on the June cover of NCB! It's a stunning depiction of
#ER-mitochondria
hotspots in
#ferroptosis
. Huge thanks to
@natcellbio.nature.com
team for this awesome recognition of our work.
@viblifesciences.bsky.social
www.nature.com/ncb/volumes/...
5 months ago
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🚨 Where does
#lipid
peroxidation kick off in
#ferroptosis
? 🔥Excited to reveal
#ER
-
#mitochondria
#contactsites
as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano
@mariamls.bsky.social
& our amazing collaborators who made this breakthrough possible!
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Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
https://doi.org/10.1038/s41556-025-01668-z
5 months ago
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🚨 Where does lipid peroxidation kick off in ferroptosis? 🔥Excited to reveal ER-mitochondria contacts as hotspots of the lipid peroxidation cascade! Kudos to our Maria Livia Sassano
@mariamls.bsky.social
🙏 to our amazing collaborators
#Ferroptosis#contactsites#ER#mitochondria
#
doi.org/10.1038/s415...
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Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
https://doi.org/10.1038/s41556-025-01668-z
5 months ago
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Congratulations on your publication
@francirizz.bsky.social
! You revealed the secrets of mitochondria-lysosome contacts 👏👏👏 Another achievement .. soon the new one!
journals.sagepub.com/doi/10.1177/...
8 months ago
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reposted by
Agostinis Lab
Adrian Liston
10 months ago
Academics get so jaded about institutions, when they reach a
#leadership
position many feel
#researchculture
is unactionable. Me and
@deefitzgerald.bsky.social
wrote a guide in
@immunolcellbiol.bsky.social
on leadership nurturing a positive culture 1/13
onlinelibrary.wiley.com/doi/10.1111/...
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<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Positive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. Here we focus on key a...
https://onlinelibrary.wiley.com/doi/10.1111/imcb.12795
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reposted by
Agostinis Lab
bioRxivpreprint
10 months ago
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
https://www.biorxiv.org/content/10.1101/2025.01.06.631537v1
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reposted by
Agostinis Lab
Rosa Ritunnano
11 months ago
Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.
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432
reposted by
Agostinis Lab
Itai Yanai
12 months ago
Is basic science undervalued? David Glanzman (UCLA) talks about the decline of 'middle class' labs and that "there is no empirical evidence that the translational approach accomplishes this [cures] any better than the traditional one. Claims to the contrary at this point are mere propaganda."
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Hi Bluesky crew! New here and excited to connect 😀 This is our most recent preprint where we describe the molecular machinery regulating iron transport between lysosomes and mitochondria.. 1/2
www.researchsquare.com/article/rs-5...
12 months ago
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