The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Mitochondrial fumarate inhibits Parkin-mediated mitophagy: Molecular Cell www.cell.com/molecular-ce...

Check out GP2's latest Micro e-Learning video on #openscience. You'll learn what open science is, why it matters in today's research landscape, and how it promotes transparency, collaboration, and accessibility. 📺 Watch to learn more: www.youtube.com/watch?v=hTzZ...

New tenure track assistant professor position in molecular microbiology in our department @dmf-unil.bsky.social @unil.bsky.social! We are casting a wide net for an experimental molecular microbiologist. Apply here: wwwfbm.unil.ch/releve/appli...

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control #mitophagy #Pink1 #mitochondria #ISR #Neurodegeneration @mrcppu.bsky.social www.science.org/doi/10.1126/...

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology rdcu.be/ehbaL

Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...

Using data from the PPMI cohort, CRN Team Chen tested whether baseline α-syn seeding activity was associated with disease progression in sporadic, LRRK2, & GBA PD & found no statistically significant associations. 🔗 Read their recent #preprint: www.medrxiv.org/content/10.1...

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

CRN Team Hurley elucidated a structural pathway of enzyme activation through cryo-EM analysis of PI3KC3-C1, showing that the activation of the VPS34 lipid kinase complexes is mediated by the myristoylated, GTP-binding pseudokinase VPS15. 🔗 Read their full #publication: shorturl.at/hdwih

ICYMI: New online: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

🎉 The CRN Collaborative Meeting brought together ~400 scientists, advocates, & people living with #PD. From groundbreaking discoveries to powerful stories, this year’s meeting wasn’t just about research; it was about impact. 🔗 Check out the recap blog: parkinsonsroadmap.org/news/highlig...

CRN Team Schlossmacher utilized serial confocal imaging and single-nucleus RNA sequencing to evaluate the efficacy of 11 different AAV serotypes in transducing murine olfactory sensory neurons via non-invasive nasal inoculation. 🔗 Check out their #publication: www.frontiersin.org/journals/neu...

Niemi lab and @washubbsb.bsky.social graduate student Youmian Yan gave a fantastic presentation on her work at the @asbmb.bsky.social meeting in Chicago! #ProudPI (photo credit to @kerikozul.bsky.social)

#Autophagy and #mTOR papers and pre-prints from last week, have a peep! biomed.news/bims-auttor/...

🧠🗑️ Just like we take out the rubbish, our cells use autophagy to clear waste. When it fails, conditions like #ParkinsonsDisease can arise. WEHI’s Prof Michael Lazarou joins Radio National to discuss his new research & potential treatments. @lazaroulab.bsky.social www.abc.net.au/listen/progr...

Just wrapped up #FCQC2025! Over 300 scientists gathered to explore autophagy, disease pathogenesis & more. Huge thanks to @idikic.bsky.social, Volker Doetsch, Maike Windbergs & all who made this conference a success! See you at #FCQC2027! @sfb1177.bsky.social @proxidrugs.bsky.social

Trying to find all the metabolism/mito folks on here, so i created a starter pack. Please suggest anyone I missed! go.bsky.app/C2t7snh

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

Fantastic initiative by @science.org and Westlake University: a series of themed online symposia on hot topics Kicking off with Mitochondria, March 19, 13:00 CET Register us02web.zoom.us/webinar/regi... Speakers: Patrick Chinnery, Luca Scorrano, Aleksandra Trifunovic, Min Jiang, @smhsci.bsky.social

Structure of human mitochondrial pyruvate carrier - what a milestone by the wonderful Dan Ma's lab from Westlake! Using Xudong Wu's expertise in nanoantibodies, they capture MPC during transport, revealing its pseudo-symmetric model and alternate opening mechanism with functional cardiolipin. Bravo!

The next frontier in #autophagy is understanding how it functions across cell types to maintain organismal homeostasis. w/ @moritznowack.bsky.social lab, we present TWO #preprint on cell type spec. autophagy in root hairs‼️ #plantscience www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Come to St. Louis this summer for the United Mitochondrial Disease Foundation MitoMed 2025 Conference! We have a fantastic line up with lots of opportunities for short talks. We're also running a Masterclass for Early Career Investigators. More info here: www.umdfconference.org

New preprint alert! In this study, we show that ATG2A engages Rab1 membranes, which are essential to autophagy. These membranes are recruited to the PAS at an early stage during autophagosome biogenesis. Tutorial to come! www.biorxiv.org/content/10.1...

Proud to report our latest work on the mechanism of substrate cleavage by the mitochondrial processing peptidase (MPP). Kudos to Andrew Bayne who drove this project, with help from new PhD student Danielle Simons and Naoto Soya in the Lukacs lab. 1/n www.biorxiv.org/content/10.1...

Excited that this is finally out! Great work by Jared Field for his PhD. @chrimanitoba.bsky.social @dream-diabetes.bsky.social www.tandfonline.com/doi/full/10....

PINK1/Parkin-dependent mitophagy caught in situ by cryo-ET! New preprint www.biorxiv.org/content/10.1... led by @kev-in-situ-et.bsky.social. This has been a long-standing goal of team @mito911.bsky.social within the @asapresearch.parkinsonsroadmap.org initiative.

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social

Happy to see our invited review on "Advances in mitophagy initiation mechanisms" is now online! We summarised the recent important discoveries in understanding how our cells trigger the formation of "cellular garbage bags" to clean up their unwanted mitochondria. doi.org/10.1016/j.ce...

Happy to see our invited review on "Advances in mitophagy initiation mechanisms" is now online! We summarised the recent important discoveries in understanding how our cells trigger the formation of "cellular garbage bags" to clean up their unwanted mitochondria. doi.org/10.1016/j.ce...

So happy and proud to share the publication of our paper demonstrating a role for SNX10 in piecemeal mitophagy and mitochondrial bioenergetics. @jcb.org

🔄 Repost because the previous link was broken! To degrade or not to degrade! We put together an Autophagic Punctum with @wilflinglab.bsky.social on our latest paper, take a look if you're interested! 🔗 www.tandfonline.com/doi/full/10....

Today, A/Prof @timsargeant.bsky.social accepted an incredibly generous donation following his gripping talk at the Sohn Hearts and Minds Conference last November. 👏 SAHMRI sends our most sincere thanks both to Sohn and the state government for the invaluable opportunity and support.

We’re Hiring: 18 PhD Positions Available! 👉MENTOR is a cutting-edge multi-disciplinary training network focused on mTOR signaling 👉We aim to recruit talented doctoral candidates to contribute to groundbreaking research on mTORopathies and their therapeutic potential. #PhDPositions #mTORResearch

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Great night at conference #AussieMit2024! fun organising with Kate, Luke, Cara, Nikeisa and Simon!