Check how the authors demonstrate that 14,15-EET drives adenoma-carcinoma progression by inducing EMT through AKT/ERK signaling activation and how it highlights its potential as both a diagnostic biomarker for early-stage risk stratification and a therapeutic target.

“14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence” 🔵 Jiangchao Li ‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their findings underscore the significance of the IFFO1/LaminA/C/PGC1α pathway as a key regulator of mitochondrial fission and fatty acid synthesis during BC progression and highlight its potential as a therapeutic target for breast cancer.

“IFFO1 inhibits breast cancer by coordinating mitochondrial fission and fatty acid synthesis via the LaminA/C-PGC1α axis” 🔵Impressive research led by Huaxia Cai & Jianjun He is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study showed that BAP1 can significantly protect cells against SLC7A11-mediated disulfidptosis, induced by glucose starvation, by lowering NADP⁺/NADPH levels, which may confer resistance to disulfidptosis.

“Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels” 🔵 Interesting research led by Qiuran Xuwas featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis” 🔵 Veli-Matti Kähäri‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how upregulation of C1s in cSCC contributes to tumor progression and serves as a protective mechanism against TRAIL-induced apoptosis, highlighting its potential as a biomarker in aggressive cSCC and a therapeutic target, where a dual-targeting approach, could be particularly effective.

Check how this study showed that BAP1 can significantly protect cells against SLC7A11-mediated disulfidptosis, induced by glucose starvation, by lowering NADP⁺/NADPH levels, which may confer resistance to disulfidptosis.

“Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels” 🔵 Interesting research led by Qiuran Xuwas featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how the authors demonstrates that teriflunomide, an FDA-approved drug, acts as a dual inhibitor of both PD-1 and PD-L1, promoting CD8+ T-cell-mediated antitumor immunity in CRC models.

“Teriflunomide modulates the PD-1/PD-L1 axis and enhances antitumor immunity in colorectal cancer” 🔵 Hwan-Suck Chung‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their findings underscore TFCP2L1’s pathological significance in HCC progression, supporting its potential as a prognostic biomarker and therapeutic target in this disease.

“TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma” 🔵 Interesting research led by Changchang Jia was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study highlights a distinct role for ZBTB7B in LUAD, where ZBTB7B it is upregulated and contributes to tumor progression by directly enhancing glycolysis, offering potential therapeutic targets for metabolic intervention in LUAD.

“Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma” 🔵 Tao Wang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Building on our 2019 study, we show why some DLBCL patients relapse after L-asparaginase: metabolic rewiring drives DNA damage and PARP1/2 dependence. Targeting this with olaparib exploits resistance and enhances killing. Kudos to @ChicheJohanna www.nature.com/articles/s41...

Check how this study highlights the potential of using STAT3 inhibition to enhance the efficacy of PI3K inhibitor in the treatment of bladder cancer by blocking the rebound activation of JAK1-STAT3 signalling, which protects against cell death and maintains proliferation upon PI3K inhibition.

“Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth” 🔵 Interesting research led by Yang Li was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their study reveals a novel HPV16 E7-APC2-SPIN4 axis as a key driver of cervical cancer, where APC2 unexpectedly functions as an oncogene by activating the Wnt/β-catenin signaling to promote tumorigenesis and CSC properties.

“Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer” 🔵 Shizhou Yang ‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how the authors demonstrated that USP21 physically interacts with G3BP1, enhancing its protein stability and thereby promoting ESCC progression through activation of the Wnt/β-catenin signaling pathway.

“USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling” 🔵 Interesting research led by Xiaogang Zhao has been featured in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

Check how their findings uncover a muscle-induced pseudo-hypoxic program that restricts cancer cell proliferation. Therefore, they highlight the need for caution in targeting hypoxia in anti-metastatic therapies, as such it could weaken skeletal muscle’s natural defense against tumor colonization.

“Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells” 🔵 Jerome Ruzzin‘s latest research is available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

Check how this study shows that TH1579 has the potential to improve ICI treatment by modulating immune checkpoint-related proteins and pathways.

“Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway” 🔵 Interesting research led by Thomas Helleday has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this study suggests FABP4-mediated FA metabolism as a therapeutic target to counteract T cell senescence in adipocyte-rich TME, providing a novel immunotherapeutic strategy for Ovarian Cancer.

“Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer” 🔵 Weimin Deng ‘s research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

Check how their study suggests that PHF2 acts as a candidate epigenetic tumour suppressor in HCC patients through the downregulation of SRXN1independent of Nrf2.

“The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1” 🔵 Edward Kai-Hua Chow‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their results suggest that USP32 activates the RAF/MEK/ERK signaling pathway, which in turn promotes NSCLC cell proliferation, migration, and EMT progression through deubiquitination and stabilization of BAG3.

“USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway” 🔵 Interesting research led by Chunyan Liu has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their study presents a novel model for understanding how genetic alterations in cytoskeletal genes can directly contribute to cancer development and drive cancer evolution and shows it can lead to the reactivation of cancer dormancy and tumour spread.

“Cytoskeleton reorganization induced by a novel K6-K14 keratin fusion promotes cancer stemness and cellular plasticity via cGAS-STING selection” 🔵 Jim Jinn-Chyuan Sheu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

As an advocate for Oncogenesis, I regularly encourage colleagues to submit their latest studies to the journal and aim to promote Oncogenesis broadly through cancer research networks. We are very lucky to have him on the team at Oncogenesis! 🤝

I have served as Associate Editor of Oncogenesis for over 5 years and in this role, I continually strive to ensure we publish high quality research and new insights in these areas.

🧬 Meet One of Our Associate Editor: Philip Gregory As head of the Gene Regulation in Cancer laboratory at the Centre for Cancer Biology in Adelaide, my research focusses on understanding how epigenetic changes regulate cancer cell plasticity and contribute to metastasis and treatment resistance.

Check how their findings demonstrate that Rab37 governs macrophage phenotype and function by orchestrating OPN/STAT3 signalling, thereby reinforcing an immunosuppressive TME and promoting lung cancer progression.

“Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression” 🔵 Yi-Ching Wang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their study revealed a potential mechanism by which DAB2IP can act as a scaffold to promote the interaction between HIF-1α and STUB1, thus inducing HIF-1α ubiquitylation degradation and inhibiting glucose uptake in breast cancer cells under hypoxic conditions.

“DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer” 🔵 Interesting research led by Jie Shen has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how their findings uncover a novel PRAS40/PGK1 regulatory axis that promotes CRC stemness and tumorigenesis through enhanced glycolysis, suggesting potential therapeutic strategies targeting this axis for CRC treatment.

“PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation” 🔵Lin Huang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how demonstrated that combination therapies targeting PKC and PKC-independent signalling nodes, including PI3K/AKT activity, are required to improve responses in patients with metastatic uveal melanoma.

“PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma” 🔵 Outstanding research led by Helen Rizos has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Check how this work provides evidence that targeting mitochondrial PE synthesis is sufficient to disrupt mitochondrial metabolism and promote oxidative stress, which may be a metabolic vulnerability that can be targeted to slow HCC progression.

“Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma” 🔵 Timothy D. Heden‘s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

The authors demonstrated that B-lymphocyte kinase (BLK) inhibition targets the cancer stem cell (CSC) population. Combining conventional chemotherapy, which eliminates bulk tumor cells, with BLK inhibition could constitute a two-pronged therapeutic strategy that may improve patient survival.

“Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells” 🔵 Interesting research led by Sean B. Lee has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...