“Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth” 🔵 Interesting research led by Yang Li was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer” 🔵 Shizhou Yang ‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling” 🔵 Interesting research led by Xiaogang Zhao has been featured in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells” 🔵 Jerome Ruzzin‘s latest research is available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway” 🔵 Interesting research led by Thomas Helleday has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer” 🔵 Weimin Deng ‘s research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1” 🔵 Edward Kai-Hua Chow‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway” 🔵 Interesting research led by Chunyan Liu has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Cytoskeleton reorganization induced by a novel K6-K14 keratin fusion promotes cancer stemness and cellular plasticity via cGAS-STING selection” 🔵 Jim Jinn-Chyuan Sheu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editor: Philip Gregory As head of the Gene Regulation in Cancer laboratory at the Centre for Cancer Biology in Adelaide, my research focusses on understanding how epigenetic changes regulate cancer cell plasticity and contribute to metastasis and treatment resistance.

“Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression” 🔵 Yi-Ching Wang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer” 🔵 Interesting research led by Jie Shen has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation” 🔵Lin Huang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma” 🔵 Outstanding research led by Helen Rizos has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma” 🔵 Timothy D. Heden‘s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells” 🔵 Interesting research led by Sean B. Lee has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Dual roles of USP1 in HELLS deubiquitination and SUMOylation drive EMT and FOLFOX-based chemoresistance” 🔵 Wenjie Zheng’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α” 🔵 Interesting research led by Kun Meng was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer” 🔵 Alice Carrier’s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression” 🔵 Interesting research led by Xiaoping Zou was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression” 🔵Chengrong Xie’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer” 🔵 Hui-Ping Hsu’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Happy Holidays and Best Wishes for 2026! As the year comes to an end, we would like to thank our readers, authors, reviewers, and the entire research community for their continued support and engagement with Oncogenesis. We wish you a joyful holiday season and a successful and inspiring New Year!

“Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain” 🔵 Mar Orzáez’s fundamental research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5” 🔵Wangjun Yan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editors: Shensi Shen @seansi.bsky.social As an Associate Professor and head of the Cancer Cell Plasticity Laboratory at the Institute of Thoracic Oncology, West China Hospital of Sichuan University, Chengdu, my research delves into the adaptive resilience of cancer.

“CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis” 🔵Yang Song’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker” 🔵 Jinlong Yin impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2” 🔵Kyle N. Cowan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α” 🔵 Interesting research led by Jian Fuhas was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1” 🔵 Changwei Ji’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma” 🔵 Groundbreaking research led by Carol J. Thielehas been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression” 🔵 Can Huang’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway” 🔵 Interesting research led by Yongfu Zhao has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

"Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis" 🔵 Jessica Silva-Fisher latest and outstanding research is now available to read in #Oncogenesis. ▶️ Read the open access article here: www.nature.com/articles/s41...

“SYT7 accelerates nasopharyngeal carcinoma progression via ALDH1A3-mediated STAT3 signaling activation” 🔵 Interesting research led by Xinxin Xiang has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🔬 Oncogenesis at the 6th Metabolism & Cancer Meeting 🔬 We were proud to support the 6th Metabolism & Cancer Meeting, held on 8–10 October in La Grande-Motte, France. #CancerResearch #Metabolism #Oncogenesis #ScientificMeeting

“A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST” 🔵 Interesting research led by Jiandang Shi has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“GlycoRNAs are abundant in glioma and involved in glioma cell proliferation” 🔵 Lin Wang latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editors: Maarten Bijlsma I am the scientific director of the Cancer Center Amsterdam, Amsterdam UMC, and professor of Experimental Gastrointestinal Oncology. My group is trying to find out why pancreatic and esophageal cancers are so hard to treat effectively.

“Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay” 🔵 Guo Chen latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

"NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development” 🔷Outstanding research from Lisheng Wang is now available to read in #Oncogenesis ▶️Read the full open access article here: www.nature.com/articles/s41...

“ONC201 enhances the cytotoxic effect of cisplatin through ATF3/ATF4/CHOP in head and neck squamous cell carcinoma cells” 🔵 Interesting research led Ming-Huei Chou has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma” 🔵 Tao Jiang’s groundbreaking research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression” 🔵 Xiaomin Bao latest and outstanding research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway” 🔵 Interesting research led by Shengtao Zhu has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer” 🔷 Haijie Li & Jingqin Lan latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🔬 Oncogenesis at SA2M 2025 🔬 Oncogenesis was proud to support the Swiss Apoptosis & Autophagy Meeting (SA2M), held on 4–5 September 2025 at the Institute of Pathology, Inselspital, Bern and organized by Life Sciences Switzerland (LS2) - Autophagy

“Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis” 🔷 Zhenye Yang latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬Meet One of Our Associate Editors: Jerry Chipuk, PhD As a Professor of Oncological Sciences and Associate Director of the Tisch Cancer Institute at MS in NY, his research focuses on how mitochondria dictate fundamental cell biology, impact upon cancer mechanisms, and mediate therapeutic responses.