“Tumor cell-derived ISG15 promotes fibroblast recruitment in oral squamous cell carcinoma via CD11a-dependent glycolytic reprogramming” 🔵 Interesting research led by Ya-Wen Chen was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“GPX3 suppresses gallbladder cancer progression by modulating redox balance, glycolysis, and anti-tumor immunity” 🔵Impressive research led by Binglu Li is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination” 🔵 Interesting research led by Yi Feng was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation” 🔵 Mark M. Huycke‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Subtype-specific role for Jagged1 in promoting or inhibiting breast tumor formation” 🔵 Interesting research led by Keli Xu was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL” 🔵 Interesting research led by Bingzong Li was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“SYT7 accelerates nasopharyngeal carcinoma progression via ALDH1A3-mediated STAT3 signaling activation” 🔵 Interesting research led by Xinxin Xiang has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“The branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC” 🔵 Interesting research led by Pei-Jen Lou was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“14,15-epoxyeicosatrienoic acid drives intestinal adenoma growth and its value as an early biomarker for intestinal adenoma occurrence” 🔵 Jiangchao Li ‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“IFFO1 inhibits breast cancer by coordinating mitochondrial fission and fatty acid synthesis via the LaminA/C-PGC1α axis” 🔵Impressive research led by Huaxia Cai & Jianjun He is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels” 🔵 Interesting research led by Qiuran Xuwas featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“C1s protects cutaneous squamous carcinoma cells from TRAIL-induced apoptosis” 🔵 Veli-Matti Kähäri‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Tumor suppressor BAP1 suppresses disulfidptosis through the regulation of SLC7A11 and NADPH levels” 🔵 Interesting research led by Qiuran Xuwas featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Teriflunomide modulates the PD-1/PD-L1 axis and enhances antitumor immunity in colorectal cancer” 🔵 Hwan-Suck Chung‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“TFCP2L1 drives stemness and enhances their resistance to Sorafenib treatment by modulating the NANOG/STAT3 pathway in hepatocellular carcinoma” 🔵 Interesting research led by Changchang Jia was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Inhibition of ZBTB7B-mediated ADPGK transcription by NEDD4 impedes glycolysis and progression of lung adenocarcinoma” 🔵 Tao Wang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Common gene mutations in 103 authenticated colorectal cancer cell lines” 🔵 Ragnhild A. Lothe‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Combined Inhibition of PI3K and STAT3 signaling effectively inhibits bladder cancer growth” 🔵 Interesting research led by Yang Li was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer” 🔵 Shizhou Yang ‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“USP21-mediated G3BP1 stabilization accelerates proliferation and metastasis of esophageal squamous cell carcinoma via activating Wnt/β-Catenin signaling” 🔵 Interesting research led by Xiaogang Zhao has been featured in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“Transcriptomic profiling of co-cultured cancer-host cells identifies hypoxia as a driver of the skeletal muscle cell’s anti-proliferative effect on cancer cells” 🔵 Jerome Ruzzin‘s latest research is available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“Mitotic MTH1 inhibitor TH1579 induces PD-L1 expression and inflammatory response through the cGAS-STING pathway” 🔵 Interesting research led by Thomas Helleday has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Fatty acid uptake mediated by FABP4 promotes the formation of CD8+T cell senescence through lipid peroxidation in the adipocyte-rich microenvironment of Ovarian Cancer” 🔵 Weimin Deng ‘s research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

“The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1” 🔵 Edward Kai-Hua Chow‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway” 🔵 Interesting research led by Chunyan Liu has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Cytoskeleton reorganization induced by a novel K6-K14 keratin fusion promotes cancer stemness and cellular plasticity via cGAS-STING selection” 🔵 Jim Jinn-Chyuan Sheu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editor: Philip Gregory As head of the Gene Regulation in Cancer laboratory at the Centre for Cancer Biology in Adelaide, my research focusses on understanding how epigenetic changes regulate cancer cell plasticity and contribute to metastasis and treatment resistance.

“Rab37-mediated OPN secretion enriches SPP1+ macrophages through autocrine–paracrine signaling to drive lung tumor progression” 🔵 Yi-Ching Wang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“DAB2IP inhibits glucose uptake by modulating HIF-1α ubiquitination under hypoxia in breast cancer” 🔵 Interesting research led by Jie Shen has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“PRAS40 promotes colorectal cancer stemness by enhancing glycolysis through triggering PGK1 acetylation” 🔵Lin Huang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“PKC-independent PI3K signalling diminishes PKC inhibitor sensitivity in uveal melanoma” 🔵 Outstanding research led by Helen Rizos has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma” 🔵 Timothy D. Heden‘s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells” 🔵 Interesting research led by Sean B. Lee has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Dual roles of USP1 in HELLS deubiquitination and SUMOylation drive EMT and FOLFOX-based chemoresistance” 🔵 Wenjie Zheng’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α” 🔵 Interesting research led by Kun Meng was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer” 🔵 Alice Carrier’s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression” 🔵 Interesting research led by Xiaoping Zou was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression” 🔵Chengrong Xie’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer” 🔵 Hui-Ping Hsu’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Happy Holidays and Best Wishes for 2026! As the year comes to an end, we would like to thank our readers, authors, reviewers, and the entire research community for their continued support and engagement with Oncogenesis. We wish you a joyful holiday season and a successful and inspiring New Year!

“Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain” 🔵 Mar Orzáez’s fundamental research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5” 🔵Wangjun Yan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editors: Shensi Shen @seansi.bsky.social As an Associate Professor and head of the Cancer Cell Plasticity Laboratory at the Institute of Thoracic Oncology, West China Hospital of Sichuan University, Chengdu, my research delves into the adaptive resilience of cancer.

“CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis” 🔵Yang Song’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker” 🔵 Jinlong Yin impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2” 🔵Kyle N. Cowan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α” 🔵 Interesting research led by Jian Fuhas was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1” 🔵 Changwei Ji’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma” 🔵 Groundbreaking research led by Carol J. Thielehas been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression” 🔵 Can Huang’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...