“Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma” 🔵 Timothy D. Heden‘s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells” 🔵 Interesting research led by Sean B. Lee has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Dual roles of USP1 in HELLS deubiquitination and SUMOylation drive EMT and FOLFOX-based chemoresistance” 🔵 Wenjie Zheng’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α” 🔵 Interesting research led by Kun Meng was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer” 🔵 Alice Carrier’s latest and impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“DDX3X interacts with SIRT7 to promote PD-L1 expression to facilitate PDAC progression” 🔵 Interesting research led by Xiaoping Zou was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Stabilization of FASN by USP5-mediated deubiquitination promotes hepatocellular carcinoma progression” 🔵Chengrong Xie’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer” 🔵 Hui-Ping Hsu’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Happy Holidays and Best Wishes for 2026! As the year comes to an end, we would like to thank our readers, authors, reviewers, and the entire research community for their continued support and engagement with Oncogenesis. We wish you a joyful holiday season and a successful and inspiring New Year!

“Phenotyping of cancer-associated somatic mutations in the BCL2 transmembrane domain” 🔵 Mar Orzáez’s fundamental research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“YTHDF3 promotes breast cancer osteolytic bone metastasis by enhancing the translation of ZEB1 and SMAD5” 🔵Wangjun Yan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editors: Shensi Shen @seansi.bsky.social As an Associate Professor and head of the Cancer Cell Plasticity Laboratory at the Institute of Thoracic Oncology, West China Hospital of Sichuan University, Chengdu, my research delves into the adaptive resilience of cancer.

“CMKLR1/PKA signaling reinforces sonic hedgehog pathway to promote medulloblastoma pathogenesis” 🔵Yang Song’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“P4HB maintains Wnt-dependent stemness in glioblastoma stem cells as a precision therapeutic target and serum marker” 🔵 Jinlong Yin impressive research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2” 🔵Kyle N. Cowan’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“LUBAC promotes angiogenesis and lung tumorigenesis by ubiquitinating and antagonizing autophagic degradation of HIF1α” 🔵 Interesting research led by Jian Fuhas was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“SLC6A19-mediated tryptophan uptake suppresses renal cell carcinoma metastasis via activating NAD+-dependent deacetylase SIRT1” 🔵 Changwei Ji’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma” 🔵 Groundbreaking research led by Carol J. Thielehas been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“NFATc1-mediated activation of the pentose phosphate pathway and cell cycle dysregulation collectively drive tumor progression” 🔵 Can Huang’s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“EPHA5 promotes cell proliferation and inhibits apoptosis in Follicular Thyroid Cancer via the STAT3 signaling pathway” 🔵 Interesting research led by Yongfu Zhao has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

"Investigation of lncRNA expression in newly diagnosed multiple myeloma reveals a LINC01432-CELF2 axis as an inhibitor of apoptosis" 🔵 Jessica Silva-Fisher latest and outstanding research is now available to read in #Oncogenesis. ▶️ Read the open access article here: www.nature.com/articles/s41...

“SYT7 accelerates nasopharyngeal carcinoma progression via ALDH1A3-mediated STAT3 signaling activation” 🔵 Interesting research led by Xinxin Xiang has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🔬 Oncogenesis at the 6th Metabolism & Cancer Meeting 🔬 We were proud to support the 6th Metabolism & Cancer Meeting, held on 8–10 October in La Grande-Motte, France. #CancerResearch #Metabolism #Oncogenesis #ScientificMeeting

“A HOTAIR-associated super-enhancer orchestrates glioblastoma malignancy via MEST” 🔵 Interesting research led by Jiandang Shi has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“GlycoRNAs are abundant in glioma and involved in glioma cell proliferation” 🔵 Lin Wang latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬 Meet One of Our Associate Editors: Maarten Bijlsma I am the scientific director of the Cancer Center Amsterdam, Amsterdam UMC, and professor of Experimental Gastrointestinal Oncology. My group is trying to find out why pancreatic and esophageal cancers are so hard to treat effectively.

“Non canonical BRCA1 promotes cell survival via modulating PARP13-mediated SEC61G mRNA decay” 🔵 Guo Chen latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

"NAC1 transcriptional activation of LDHA induces hepatitis B virus immune evasion leading to cirrhosis and hepatocellular carcinoma development” 🔷Outstanding research from Lisheng Wang is now available to read in #Oncogenesis ▶️Read the full open access article here: www.nature.com/articles/s41...

“ONC201 enhances the cytotoxic effect of cisplatin through ATF3/ATF4/CHOP in head and neck squamous cell carcinoma cells” 🔵 Interesting research led Ming-Huei Chou has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“CENPF (+) cancer cells promote malignant progression of early-stage TP53 mutant lung adenocarcinoma” 🔵 Tao Jiang’s groundbreaking research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“A dominant SRCAP truncating mutation promotes squamous cell carcinoma progression” 🔵 Xiaomin Bao latest and outstanding research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“RIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway” 🔵 Interesting research led by Shengtao Zhu has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer” 🔷 Haijie Li & Jingqin Lan latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🔬 Oncogenesis at SA2M 2025 🔬 Oncogenesis was proud to support the Swiss Apoptosis & Autophagy Meeting (SA2M), held on 4–5 September 2025 at the Institute of Pathology, Inselspital, Bern and organized by Life Sciences Switzerland (LS2) - Autophagy

“Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis” 🔷 Zhenye Yang latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

🧬Meet One of Our Associate Editors: Jerry Chipuk, PhD As a Professor of Oncological Sciences and Associate Director of the Tisch Cancer Institute at MS in NY, his research focuses on how mitochondria dictate fundamental cell biology, impact upon cancer mechanisms, and mediate therapeutic responses.

“Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse” 🔷 Outstanding research from J. Pannequin, W. Bourguet, M. Amblard & JM Pascussi is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Peptidylarginine deiminase 3 modulates response to neratinib in HER2 positive breast cancer” 🔷 High-impact research led by Atanasio Pandiellahas has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Targeting macrophage migration inhibitory factor as a potential therapeutic strategy in colorectal cancer” 🔷 Ramona Schulz-Heddergott latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Condensate remodeling reorganizes innate SS18 in synovial sarcomagenesis” ✨ Interesting findings from research led by Duanqing Pei has been featured in #Oncogenesis. ▶️Read the full open access article here: www.nature.com/articles/s41...

“Novel CDK2/CDK9 inhibitor fadraciclib targets cell survival and DNA damage pathways and synergizes with encorafenib in human colorectal cancer cells with BRAF(V600E)” Discover Frank A. Sinicrope's newest findings, now featured in #Oncogenesis Read the full article: www.nature.com/articles/s41...

“Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma” 🔷 Hui-Zhen Nie noteworthy study has been published in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Inhibition of LDHB triggers DNA damage and increases cisplatin sensitivity in pleural mesothelioma” 🔷 Thomas Michael & Marti Patrick Dorn latest research is now available to read in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“YAP/TAZ interacts with RBM39 to confer resistance against indisulam” Groundbreaking research led by Mikihito Kajiya has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

'Collagen type IV alpha 6 promotes tumor progression and chemoresistance in ovarian cancer by activating the discoidin domain receptor 1 pathway' 🔷Soon-Cen Huang & Chou Cheng-Yang latest research is now available to read in #Oncogenesis ▶️ Read the full article here: www.nature.com/articles/s41...

“Involvement of Kindlin-1 in cutaneous squamous cell carcinoma” 🔷 Interesting research led by Valerie G. Brunton has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Targeting SLC7A5 in lung SC carcinoma: implications for cancer metabolism shift and boron neutron capture therapy resistance” 🔷 High-impact research led by Min-Yuan Chou & Yu-Ting Chou has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“Activated platelet-derived exosomal LRG1 promotes multiple myeloma cell growth” 🔵 Yanwei Luo’s groundbreaking research appeared in #Oncogenesis ▶️ Read the full open access article here: www.nature.com/articles/s41...

“GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells” 🔷 Jan Paul Medema latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

“STAG2 expression imparts distinct therapeutic vulnerabilities in muscle-invasive bladder cancer cells” 🔷 High-impact research led by Anna Woloszynska has been featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...