The final Calvin and Hobbes, which appeared in papers 30 years ago today.

Online Now: RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria Online now:

scoop: During a heated conference call this spring, the head of the Corporation for Public Broadcasting told Katherine Maher, the C.E.O. of NPR, that she should resign. My profile of Katherine Maher, which goes behind-the-scenes of the most consequential fight in NPR’s history.

it's completely bullshit that if I am paying open access fees, that the journals are not depositing the paper into NCBI.

@acs.org has still not returned its inclusivity guides based on race/ethnicity or gender/sex/sexual-orientation/gender-identity. The idea that they "paused" them for "review and refinement" was a cover for caving to the Trump administration. @professor-dave.bsky.social www.acs.org/about/inclus...

New preprint! We found that the flavin-dependent halogenase RebH catalyzes sequence-tolerant Trp bromination in peptides 🧪https://www.biorxiv.org/content/10.64898/2025.12.17.694899v1

New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations! pubs.acs.org/doi/full/10....

Christmas-physics cross-over joke

I’m laid up with the flu, but I had to peek my head out and say that this is *so* much worse than it seems. And it’s already pretty fucking bad! bsky.app/profile/gbbr...

Presenting, attending or excited to learn? #ASBMB26 is all about scientific exchange, collaboration and inspiration. Introduce yourself using this social media toolkit and meet fellow attendees before the conference kicks off — counting down to March! www.asbmb.org/annual...#ASBMB26#MakeItPossible

A Trump administration change to how the National Institutes of Health awards grants has sharply reduced early-stage investigators’ odds of securing funding, new data from the agency show. Teamed up with @aniloza.bsky.social for this @statnews.com story www.statnews.com/2025/12/18/n...

Chromatin buffers torsional stress during transcription | Science www.science.org/doi/10.1126/...

I've spent all day struggling to write a single page of a popular science article. I bang away at a word processor; give up; start diagramming on paper. Take some notes; draft a few sentences in pen; return to the computer...and very slowly I figure out what I was trying to say in the first place.

With a vibrant program featuring cutting-edge research and interdisciplinary collaboration, the 2026 ASBMB Annual Meeting offers unparalleled opportunities to deepen your expertise and broaden your impact. ☑️ Register early (by Feb. 3) and save: www.asbmb.org/annual-meeti.... #ASBMB26

Broadening engagement in BMB This #ASBMB26 symposium features speakers sharing innovative strategies to broaden engagement in BMB through inclusive teaching and mentoring, career training, and institutional policies & programs. ➡️ Explore the program: www.asbmb.org/annual-meeti.... #MakeItPossible

Just decline the peer review invitation. What are you people even doing?

All living organisms face the problem of parasites - but what happens when DNA has invaded the genome? go.nature.com/3MDiJCq

Rob Reiner: I'm going to make a coming of age drama, a fantasy adventure story, a romantic comedy, a psychological horror and then a courtroom drama. Us: Across your entire career? Reiner: In a 6 year period. Us: That sounds- Reiner: -Each one will be arguably the best movie in that genre.

I am often asked what laws I would recommend blue states adopt. While there is no one-size-fits-all approach, there are seven changes every state could adopt right now, for virtually no cost or administrative burden. www.democracydocket.com/opinion/seve...

I think some folks might be happy to see this. NIGMS MIRA R35 for EI/NI has been published. PAR-26-121 files.simpler.grants.gov/opportunitie...

YOUR STUDENTS ARE NOT YOUR CUSTOMERS. Get the fuck out of education if that's the way you're talking about them.

This is actually a good example of why the customer model is wrong. I wouldn't have chosen poetry writing, but UNC made me take a class. And it absolutely made me become a much better writer, with an eye to concision and an ear now trained to the rhythm of words. I'm a better historian as a result.

Deadline is almost here! Apply for the AGE Early Career Scholar’s Program before Dec 10. Winners receive: • 2-yr AGE membership • $1300 travel award (AGE 2026) • Chance to present research • Mentorship from senior scholars Apply now 👉 age.memberclicks.net #AgingResearch #AGECommunity #Geroscience

This afternoon, I was in a meeting with Jay Bhattacharya, and I can confirm this is *exactly* what he both wants and will be doing. THIS IS NOT HYPERBOLE.

If you want to help, you can share our story, check out our work at viralemergence.org, and - if you're the one in a million person who can save our project - reach out. (At this point, my job is to fundraise for the amazing scientists I work with, so they can focus on doing some actual science! 🦠)

NIH supported more than 407,000 jobs in 2024. Research funding strengthens communities. Join ASBMB in highlighting the value of basic research: www.asbmb.org/advoca.... #ScienceServesUsAll #ASBMBAdvocates

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis: Cell www.cell.com/cell/fulltex...

Absolutely devastating account of the CSU's $17 million capitulation to ChatGPT, from a fellow faculty member watching it happen www.currentaffairs.org/news/ai-is-d...

Every dollar invested in NIH returns $2.56 to our economy. Science funding pays off. Join ASBMB in highlighting the value of basic research: www.asbmb.org/advocacy/sci.... #ScienceServesUsAll #ASBMBAdvocates

We first note that hand-wringing about the decline in US college enrollments has mistakenly linked such declines to the price of four-year colleges. But the decline is entirely driven by two-year community colleges (and by for-profit colleges). The four-year sector is the dog that didn't bark.

This is actually quite brilliant, up to and including the final sentence 🔥

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

On AI’s ‘mediocrity trap’ — experiments indicates that while AI helps the less skilled make something passable, the highly skilled don’t use it to produce something better than they could have; they produce something ok, but lose motivation to make it great. www.jin-li.org/uploads/1/1/...

What led to the emergence of the first states, thousands of years ago? People often say agriculture, but the first large-scale societies didn't appear until 4000 years after the advent of agriculture. The answer may be growing grain, specifically. 🧪 #history www.newscientist.com/article/2505...

Here we go. Its ALL #NIHGrant applications. Dec 8 is the new deadline. And a one page prelim data update will be accepted for all May Council submissions. grants.nih.gov/grants/guide...

"essays produced by ChatGPT are soulless, boring abominations. Words, phrases and punctuation rarely used by the average college student are pervasive." www.huffpost.com/entry/histor...

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

We are hiring a postdoc! 🧪 ▶️ Project: nucleotide metabolism (genomics & biochemistry) ▶️ Start date: spring 2026 (flexible) ▶️ More info and application: tinyurl.com/3kjrbb2x Please share 🌏 @fbm-unil.bsky.social @dib-unil.bsky.social @unil.bsky.social @snsf.ch

🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI. We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods. paulunlab.psych.wisc.edu #VisionScience #NeuroSkyence

Support science!

‘Tis our favorite season of giving back to our community! ❤️ If you’d like to contribute a donation for our annual fundraiser to support Toys for Tots and Coats for the Children, check out this feature article to learn more! 😇🧸 chem.unc.edu/news/baker-l...

This work is now officially published @natsmb.nature.com with some fun new analyses included in the revised version. Congratulations to all the authors! @connyyu.bsky.social @rappsilber.bsky.social @lrsinn.bsky.social @fjoreilly.bsky.social www.nature.com/articles/s41...

Another new policy from the geniuses in NIH leadership. Apparently, ~70% of grant applications for most mechanisms will not be "triaged", i.e. not discussed at study section. This is an increase from the ~50% level that has been in place for many years. I don't know the rationale for this 1/13

the only good accent work on earth is old money transatlantic american to make fun of rich people accent

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

Can we please stop using GAPDH as a "loading control", particularly in metabolic studies??

Following a recent article about the different layers of conceptualisation in a science project, this is about a pet peeve of mine. I would love to hear your views. network.febs.org/posts/thinki...

How's your juggling act? Mitochondria also have one, and the MITOtalk this week will be all about it. See you there?