Updated preprint 🧵 We mapped how loss of 23 LSD genes reshapes neuronal proteomes in cortical (iN) and dopaminergic (iDA) neurons New in v2: We added a computational PPI pipeline assessing KO-dependent vulnerability at the interaction and complex level.

How do nanoparticles traverse the endothelial barrier in a living organism? We explored this fundamental question using the zebrafish and PEG-based nanoparticles (NPs) in our latest article: (pubs.acs.org/doi/10.1021/...).

Excited to share our latest research, out today in Cell (@cellpress.bsky.social) Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling. Read the paper here: doi.org/10.1016/j.ce...

CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪 🔗 Read the #publication: bit.ly/4qeZiOY

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Mechanism of #autophagy initiation by transmembrane selective autophagy receptors @elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors www.embopress.org/doi/full/10....

New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D

Abstract deadline approaching! Apply for a short/spotlight talk bsky.app/profile/sato...

For the love of frontier research, or why Elon’s rockets keep blowing up. The current Zeitgeist favouring utilitarian research risks undermining basic research—the very foundation on which innovative technological advances depend. By Nektarios Tavernarakis: www.embopress.org/doi/full/10....

Check out @antdlewis.bsky.social fun description of organelle contacts here bpod.org.uk/archive/2025... Great work, really enjoyed it. I will now always be imagining that organelles are at at a party! 😄

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...

📅 Less than 2 weeks left to submit your abstract for our 6th Annual Symposium Webinar! 🎉Don’t miss this chance to share your work, hear the latest advances in autophagy research, and connect with a vibrant community! 🎉 The link for abstraction submission is below 👇 forms.office.com/r/wZbTvPePwR

😺 to see this one out @jcellsci.bsky.social & have a 🌲 planted for it): journals.biologists.com/jcs/article/... am sure more creative people will make better use of this resource 1/2

Excited to share our new paper in Nature Communications: Evidence that Mitochondria in macrophages are destroyed by microautophagy 👉 rdcu.be/eDa1S

💫NEW: @molinarilab-er.bsky.social & co examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite sequence divergence, such as a net negative charge, that promote fragmentation. bit.ly/4fLWe99

Dr Linh Dang and I penned this commentary on our own article that explores cell-type specific #autophagy in humans. We discuss #aging, sex, nutrient restriction, and the technology we need to better understand this process in people: www.tandfonline.com/doi/full/10.... @sahmri.bsky.social

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉 rdcu.be/ey8iL

Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...

And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology. Huge, long-running effort by PDRA Leonor Miller-Fleming 👏 dx.plos.org/10.1371/jour...

In search for some autophagy summer reading? Check out the full Journal of Molecular Biology special issue «Autophagy accross scales - from molecules to physiology» edited by Sharon Tooze and myself: www.sciencedirect.com/journal/jour... @arcticautophagy.bsky.social @womeninautophagy.bsky.social

ATZ polymers elicit intervention of CNX:FAM134B-LC3II segregation complexes + formation of VAPA-ORP1L-RAB7 membrane contact sites to facilitate Syntaxin18/VAMP8-driven fusion of ER and endolysosomal membrane. One of the ER-to-Lysosome-Associated Degradation flavors. www.biorxiv.org/content/10.1...

Impact of federal funding cuts on science, the progress of knowledge, and our future - an essay by our own Steve Liberles: magazine.hms.harvard.edu/articles/i-t...

Very excited to share my postdoc work- out now at PNAS! Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

WSTF nuclear autophagy regulates chronic but not acute inflammation is published in Nature😀 nature.com/articles/s41... Congratulations to all collaborating groups! Fantastic effort by first author Yu Wang! Kudos to Zixhun Dou for leading the entire project!😀

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups! 🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

ABSTRACTS CLOSE 18 July! The 11th International Symposium on Autophagy 2025 📅 16–20 November 2025 | Lorne, Victoria, Australia Registration: isa11.org We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.

🎉Excited to share our latest paper, published in Nature Communications!🎉 "Enhancing autophagy by redox regulation extends lifespan in Drosophila" #redox #metabolism #ageing #Drosophila @natcomms.nature.com @mrc-lms.bsky.social doi.org/10.1038/s414...

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

#Postdoc – #ExcellenceByChoice programme! Our lab & the Kohler Mito lab are seeking researchers to study specialized mitoribosomes under stress & ageing. Apply by Aug 17 👉https://www.vkohler-lab.com/join-our-team #ExcellenceByChoice #Mitochondria #Ageing #Proteostasis

Chan Lee @harperlabhms.bsky.social reports CASM-driven V-ATPase recruitment to lysosomes for acidification upon TRPML1 activation via DMXL1-RAVE loader. With Magdalene Moran(Caraway), Sophie Helaine lab, Joao Paulo, & HarperLab teams(HMS). Funds: Warren Alpert FND/NIH www.nature.com/articles/s41...

So proud of this work by #rukmini mukherjee on intersection of Cell Biology and Microbiology

New research paper on human #autophagy from our group at @sahmri.bsky.social. Dr Linh Dang analysed autophagic flux with cell type specificity. We show data important for designing clinical trials for human autophagy - cell type matters: faseb.onlinelibrary.wiley.com/doi/10.1096/... #aging

Very proud to have our paper on ATG9A in lysosome repair online. ATG9A never disappoints! Great work from the very talented @stedet.bsky.social and @ealmacellas.bsky.social 👍 www.sciencedirect.com/science/arti...

Excited to share our newly published work on ATG9A — this time focusing on its role at the lysosome. Discover how ARFIP2 and ATG9A coordinate PI4P regulation during lysosomal repair! Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !! 📜 bit.ly/43EbrDo

ICYMI: New online: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

I'm looking forward to attending the 11th International Symposium on #Autophagy. The last one in Sapporo, Japan was a great meeting and that is set to continue in Lorne, Victoria, in November of this year. Early bird rego closes August 29 here: www.isa11.org #isa11

New preprint from the lab with our amazing collaborators 👇🏼 We further characterise the mode of action and cytoprotective properties of a p62-targeting small molecule activating autophagy, have a 👀 www.biorxiv.org/content/10.1...

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

The Labs to Lives series at @ucdavis.bsky.social highlights people who conduct federally funded research and what's at risk if it disappears. www.the-scientist.com/scientists-f...

Problem cryo-ET structure alert. A recent paper by Lange et al. in @natcellbio.nature.com (tinyurl.com/38s6a4dn) reported an unusual-looking model of the prohibitin complex in situ. We asked: how was this structure generated? Our reanalysis offers an explanation: tinyurl.com/mszdtwxx 🧵

The Hunter Meeting has made it to the blue place! 🔵 If you are joining us in the beautiful #HunterValley 2-5 June 2025 - please tag us or search #HunterMeetingOz to follow along. #STEM #CellBiology #DevBio #SpatialOmics @anzscdb.bsky.social #AustralianMeeting

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

www.wehi.edu.au/careers/make... WEHI is looking for new lab heads! New and experienced lab heads welcome. Check out the ad, consider applying and share. We’re a collaborative bunch, in Australia, with fabulous technology, great colleagues at a values-driven organisation. @wehi-research.bsky.social

Researchers from the Parkinson’s Disease Research Centre at WEHI & the National Drug Discovery Centre have discovered a molecule that blocks cell death, a finding that could lead to next-generation drugs for neurogenerative condition. www.wehi.edu.au/news/cell-de...