Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...

Just one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation https://www.biorxiv.org/content/10.1101/2025.08.16.670665v1

So happy to see @doroteaartscience.bsky.social 's art on the cover!

If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov: 👇 A quick thread + link: www.biorxiv.org/content/10.1...

New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy www.nature.com/articles/s41...

The rapidly expanding role of LC3-interacting regions in #autophagy. New Perspective from Brian North, @doroteaartscience.bsky.social, Christopher Shoemaker and colleagues (Geisel School of Medicine, Dartmouth College): rupress.org/jcb/article/...

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

🚨 Out now! Autophagy keeps cells healthy - and when it goes wrong, diseases like Parkinson’s can emerge. @elias-adriaenssens.bsky.social (Martens lab) in @natureportfolio.nature.com Cell Biology challenge the conventional hierarchy of autophagy factors ➡️ tinyurl.com/y33nrtn2

@univie.ac.at @meduniwien.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" 1/

Very excited to share my postdoc work- out now at PNAS! Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨ See all about it 👇

One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor! www.nature.com/naturecareer...

ABSTRACTS CLOSE 18 July! The 11th International Symposium on Autophagy 2025 📅 16–20 November 2025 | Lorne, Victoria, Australia Registration: isa11.org We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Very proud to have our paper on ATG9A in lysosome repair online. ATG9A never disappoints! Great work from the very talented @stedet.bsky.social and @ealmacellas.bsky.social 👍 www.sciencedirect.com/science/arti...

Excited to share our newly published work on ATG9A — this time focusing on its role at the lysosome. Discover how ARFIP2 and ATG9A coordinate PI4P regulation during lysosomal repair! Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !! 📜 bit.ly/43EbrDo

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.

CRN Team Hurley elucidated a structural pathway of enzyme activation through cryo-EM analysis of PI3KC3-C1, showing that the activation of the VPS34 lipid kinase complexes is mediated by the myristoylated, GTP-binding pseudokinase VPS15. 🔗 Read their full #publication: shorturl.at/hdwih

After all the (re-)connections on day 1, day 2 of #ubfriends2025 even more fabulous for us 🤩 BIG THANKS to all the speakers & poster presenters for sharing their exciting research, and to EVERYONE who joined us! It was a true pleasure to host this amazing community👇

Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress | Science Advances www.science.org/doi/10.1126/...

Looking for a student or postdoc! Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy? Help us uncover new protein-protein interactions — from in silico to in vitro. Join us at @istaresearch.bsky.social 👉 looselab.org 🧬💡🔬🎡

Ubiquitin & Friends Fiesta in Vienna 2025 -- Final Call despite these challenging times for science, we look forward to gather for a lively meeting and share the joy of discovery. to join an exciting program and connect with fellow ubiquitinists sign up at www.protein-degradation.org/symposium/

NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

PINK1/Parkin-dependent mitophagy caught in situ by cryo-ET! New preprint www.biorxiv.org/content/10.1... led by @kev-in-situ-et.bsky.social. This has been a long-standing goal of team @mito911.bsky.social within the @asapresearch.parkinsonsroadmap.org initiative.

Less than 3 weeks left⏳Register by April 7 for the #Ubiquitin & Friends Symposium, May 8-9, in beautiful Vienna! Fantastic guest speakers, open slots for short talks, flash talks& posters: Great opportunity for students & #ECRs! Register soon to save your spot➡️ www.protein-degradation.org/symposium/

The registration for the 2025 Ubiquitin & Friends Symposium is open! We can't wait to welcome all our TPD friends in Vienna @martenslab.bsky.social @plantophagy.bsky.social @haselbachlab.bsky.social @clausenlab.bsky.social @gekaragoz.bsky.social @thewittysquare.bsky.social @georgwinter.bsky.social

Check it out, all recorded talks in one place! 👇

❕Master's thesis opportunity! The Martens lab is offering a Master's project to investigate how Parkinson's disease aggregates impact the human brain 🧠 Don't miss this chance to dive into cutting-edge research ➡️ tinyurl.com/22epxz4r

It’s so nice to be able to celebrate something this week. Newest work from the group! How are nuclear contents delivered to the cytosolic autophagy machinery while maintaining nuclear integrity? Nuclear envelope gymnastics! Cool role for Dnm1/Drp1. www.nature.com/articles/s41...

Come and joint us at @mrclmb.bsky.social ! We have an opening for a new group leader in the Structural Studies Division. We are very interactive and collaborative with amazing facilities and generous core funding. Get in touch with myself or @sjorsscheres.bsky.social if you have any questions.

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

‪We're excited to announce that registration for the "Tiles of Life" Student Symposium is now open! With a fantastic lineup of guest speakers, complemented by SMICH student talks, we’re set for two inspiring days. Don’t miss out—register now! 🚀🎓✨ #TilesofLife #studentsymposium #SMICH

Check out this amazing speaker list our students have put together for their symposium and sign up for it! tilesoflife.com

This is tomorrow (Thursday) at 5pm CET, looking forward to it! cc/ @ishier.bsky.social @franbottanelli.bsky.social

We are pleased to introduce the 4th Frankfurt Conference on Quality Control in Life Processes organized by @idikic.bsky.social, Maike Windbergs & Volker Dötsch. The program is now available — more updates to come. fcqc.de @proxidrugs.bsky.social @sfb1177.bsky.social #FCQC2025

Deadline is approaching fast (31 /01) for the J. monod Conference on membrane dynamics ! don't miss it 👇 cjm.sb-roscoff.fr/en