More: www.imp.ac.at/news/article...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!

Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna! Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot! ➡️ www.protein-degradation.org/symposium/ #ubfriends2026

CRN Team Hurley developed AI-directed voxel extraction (AIVE), a segmentation strategy that refines AI-based organelle boundary predictions. Using AIVE, they identified a previously unknown mitochondrial contact termed the mitochondrial intrusion 🧪 🔗 Read the #publication: bit.ly/4qeZiOY

The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair Dale Corkery, Yao-Wen Wu et al link.springer.com/article/10.1...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!

There are a couple of empty chairs at our table — want to sit with us? Reach out to me or any lab member www.oeaw.ac.at/gmi/research... We’ll be hiring two postdocs in 2026. We’re excited about ambitious and creative ideas and are committed to supporting future group leaders 1/2

✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke

Join us later today 👇

🌍Open call: Junior Group Leader positions! Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery. Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...

New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs with the generous support of @asapresearch.parkinsonsroadmap.org doi.org/10.1101/2025...

Congratulations! Claudine Kraft @kraftlabfr.bsky.social receives a prestigious ERC Synergy Grant – to find out why some protein #aggregates can be cleared by #autophagy and others not. She and her partners will harness this knowledge to improve autophagy in #ageing & #disease. 🔗  kurzlinks.de/50j8

Thrilled to join you and Claudine to study the cell's own version of Banksy's self-shredding artwork!

Fantastic teamwork with @kraftlabfr.bsky.social and @jimhurley.bsky.social! Looking forward to exciting discoveries ahead. Many thanks to @erc.europa.eu for funding our proposal. @univie.ac.at @maxperutzlabs.ac.at @viennabiocenter.bsky.social

Another opportunity to join @maxperutzlabs.ac.at ! If you're looking to start your own lab in a collaborative and supportive environment, I highly recommend it! www.nature.com/naturecareer...

📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu

Our latest review is now online! 👇 @martenslab.bsky.social Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....

Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.

Finally in @nature.com 🎉 We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism. www.nature.com/articles/s41...

Just one more week left to get an application in! Starting my lab at the Perutz and the @viennabiocenter.bsky.social has been a fantastic opportunity that shaped me as a scientist!

📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin. 👇 Reserve your spot using the link below. 📅 September 8 ⏰ 11:00 AM EST RSVP: bit.ly/4mUJeAc

We are looking for a Master’s student to join a project on in vitro reconstitution of signaling networks in pathogen–host interactions: combine protein biochemistry, fluorescence microscopy & image analysis. Deadline: September 15. Find out more and apply here: ist.ac.at/en/job/maste...

Glad to share the final version of our story about the UBR4 complex, an E4 ligase protein quality control hub @science.org. Now with more cryo-EM structures and a deeper dive into substrate recognition, especially escaped mitochondrial proteins @clausenlab.bsky.social www.science.org/doi/10.1126/...

Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social www.cell.com/cell/fulltex...

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation https://www.biorxiv.org/content/10.1101/2025.08.16.670665v1

So happy to see @doroteaartscience.bsky.social 's art on the cover!

If you’re enjoying some calm while others are on holiday, here’s a #NEW #preprint to dive into — led by the brilliant @vbcscitraining.bsky.social student A. Abdrakhmanov: 👇 A quick thread + link: www.biorxiv.org/content/10.1...

New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy www.nature.com/articles/s41...

The rapidly expanding role of LC3-interacting regions in #autophagy. New Perspective from Brian North, @doroteaartscience.bsky.social, Christopher Shoemaker and colleagues (Geisel School of Medicine, Dartmouth College): rupress.org/jcb/article/...

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

🚨 Out now! Autophagy keeps cells healthy - and when it goes wrong, diseases like Parkinson’s can emerge. @elias-adriaenssens.bsky.social (Martens lab) in @natureportfolio.nature.com Cell Biology challenge the conventional hierarchy of autophagy factors ➡️ tinyurl.com/y33nrtn2

@univie.ac.at @meduniwien.ac.at

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

And another opportunity! Any postdocs looking forward to start your lab on a tenure track? Supportive environment, great core facilities and an outstanding PhD program.

📣 Paper alert!! Excited to share the 2nd research paper from my time in the @bokelab.bsky.social at @crg.eu, out today in the @embojournal.org! We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?" 1/

Very excited to share my postdoc work- out now at PNAS! Learn more about how neurons facing chronic autophagic stress compensate by upregulating two secretion pathways Autophagic stress activates distinct compensatory secretory pathways in neurons | PNAS www.pnas.org/doi/10.1073/...

👏 Big CONGRATS to @sramundo.bsky.social for receiving an FWF @fwf-at.bsky.social ASTRA Award 🌠✨ See all about it 👇

One of the most exciting discoveries from our lab so far is now online as a preprint! Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria: www.biorxiv.org/content/10.1...

Exciting and rare opportunity to join the @maxperutzlabs.bsky.social and the @viennabiocenter.bsky.social as a Full Professor! www.nature.com/naturecareer...

ABSTRACTS CLOSE 18 July! The 11th International Symposium on Autophagy 2025 📅 16–20 November 2025 | Lorne, Victoria, Australia Registration: isa11.org We have a fantastic line-up of speakers and a wide range of topics focused on the fascinating world of autophagy.

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Very proud to have our paper on ATG9A in lysosome repair online. ATG9A never disappoints! Great work from the very talented @stedet.bsky.social and @ealmacellas.bsky.social 👍 www.sciencedirect.com/science/arti...

Excited to share our newly published work on ATG9A — this time focusing on its role at the lysosome. Discover how ARFIP2 and ATG9A coordinate PI4P regulation during lysosomal repair! Congrats to all the authors, and special thanks to @stedet.bsky.social & @satooze.bsky.social !! 📜 bit.ly/43EbrDo

Michael Lazarou and I will be chairing the 11th International Symposium on Autophagy (ISA) in Australia from 16-20 Nov 2025! 📍 Location: Lorne, Victoria, Australia 🌐 Register now: www.isa11.org Join us for five inspiring days of cutting-edge autophagy research and networking opportunities.