TSC1 phosphorylation by lysosomal mTORC1 establishes a minimal autoregulatory feedback loop https://www.biorxiv.org/content/10.64898/2026.01.15.699678v1

🤠 Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex #cryoEM www.nature.com/articles/s41...

⁉️The ARC has delayed outcomes of ALL grants 1–4 months & increased scheduled outcome windows from 2 weeks to 3 months! This reverses 4 years of progress in providing greater certainty & ability to plan for researchers, their families & unis. Their excuse? Security checks under new ARC legislation👇

You can find out more here: www.cell.com/cell/fulltex...

The latest research from our team is out in Cell @cp-cell.bsky.social! We used #cryo-EM, #imaging, #BRET, and #biosensors targeted to the lysosome to understand how the KICSTOR-GATOR1 complex turns off #mTORC1 in response to low levels of amino acids.

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading "Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex pubmed.ncbi.nlm.nih.gov/41512879/ #cryoem

The #ChlamyDataset is on the cover of @cp-molcell.bsky.social 🖼️🥰! Read @lifeonthewedge.bsky.social's great thread🧵 for the inside scoop🍨 on all the #TeamTomo developments already made possible since these 1829 tomos hit EMPIAR 🧪 🧶🧬 For more, here's the old preprint thread: bsky.app/profile/cell...

Excited to share our latest research, out today in Cell (@cellpress.bsky.social) Using cryo-EM and cell-based studies, we reveal how large nutrient sensing protein complexes form at the lysosomal membrane to turn off mTORC1 and halt anabolic signalling. Read the paper here: doi.org/10.1016/j.ce...

Now online! Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

Thrilled to share our latest work @luptoncj.bsky.social @drellisdon.bsky.social @drmlhalls.bsky.social. Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. 🧪🔬#cryoEM Now online @cellpress.bsky.social. doi.org/10.1016/j.ce...

A very brief break in the clouds over Melbourne last night. The universe is stunning.

This long-awaited article demonstrates that depletion of individual essential amino acids induces profound changes in the liver epigenome, with AA-specific molecular changes at the level of histone PTMs, the transcriptome, and metabolome www.jbc.org/article/S002...

In our new preprint, we show how fibril-dynamics of signaling component TIRAP supports sensitive & fast sensing of endotoxin LPS. Congrats to co-lead @arthurfelker.bsky.social. @piehlerlab.bsky.social @arnemoeller.bsky.social #TLR #cryoEM #blender doi.org/10.64898/202...

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...

Congratulations to the Landsberg lab for a fantastic paper in Nat Comms on the structure of the YenTC toxin. Led by Yu Shang Low and Solace Roche. @dr-berger.bsky.social @sarahjpiper.bsky.social

This work started more than 5 years ago and combines molecular phylogenetics, diversification models, paleoecology and micropaleontology, requiring ~136 CPU-years 🧬💻! A lovely interdisciplinary collaboration with @phoebefossil.bsky.social, Hélèn Morlon and @fburki.bsky.social. #ProtistsOnSky

A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw

Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer | Science Signaling www.science.org/doi/10.1126/...

Exciting times for structural biology @monashuniversity.bsky.social from cryo-EM to therapeutic development of new AI-guided therapeutics. www.theage.com.au/technology/n...

@lorneproteins.bsky.social Meeting with the Lorne Protein Committee to plan for the 2026 and future meetings! @wehi-research.bsky.social

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

Nice review on #TSC and #mTORC highlighting our cryoEM structure of TSC. Phosphorylation mechanisms that modulate TSC activity still remain unknown. TBC1D7 function largely a mystery, but important in brain development / megalencephaly.

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Deep in Saturn’s northern hexagon is a 2,000 kilometer (1,250 mile) wide high-wind vortex, seen here in infrared false color. Imaged by Cassini. flic.kr/p/2g5dxDw flic.kr/p/2g4xyyQ

Great to see this study published. Congrats to Roger Daly and team! www.nature.com/articles/s41...

#Autophagy and #mTOR papers from last week, there’s always something to every taste, enjoy thanks to @Bims_BiomedNews pre-selection. biomed.news/bims-auttor/...

All-atom fixed backbone protein sequence design with FAMPNN @richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.1...

Our paper is out! LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share! structures| nanobodies |human immune responses | mRNA-LNP www.biorxiv.org/content/10.1...

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

Must read for California www.nytimes.com/2025/01/25/o...

Thanks Brett! A few more for the list re-solute.eu/resources/da... (SLCs) www.flyrnai.org/tools/fly_pr... (excellent) www.ebi.ac.uk/complexporta... prodata.swmed.edu/humanPPI/ (excellent) honiglab.c2b2.columbia.edu/PrePPI/ (unsure) predictomes.org (small target number) Any others we've missed?

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

It was perfectly clear last night until about 11pm which allowed me to finally have a good look at the Horsehead Nebula. Here is the result of 61 minutes of data (366 stacked images) from the Seestar S50. Slight enhancement in Lightroom.

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub–200-keV direct electron detector!

Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "I am a book I neither wrote nor read."-Delmore Schwartz

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪 www.rcsb.org/structure/9CE3

Did someone mix up AM and PM over at the #NHMRC? I'm all for releasing grant outcomes as soon as possible, but 1:30 AM is a rather unconventional choice!

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project. www.science.org/doi/10.1126/...

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances. Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council. www.science.org/doi/10.1126/...