A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw

Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer | Science Signaling www.science.org/doi/10.1126/...

Exciting times for structural biology @monashuniversity.bsky.social from cryo-EM to therapeutic development of new AI-guided therapeutics. www.theage.com.au/technology/n...

@lorneproteins.bsky.social Meeting with the Lorne Protein Committee to plan for the 2026 and future meetings! @wehi-research.bsky.social

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

Nice review on #TSC and #mTORC highlighting our cryoEM structure of TSC. Phosphorylation mechanisms that modulate TSC activity still remain unknown. TBC1D7 function largely a mystery, but important in brain development / megalencephaly.

Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!

Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social

Deep in Saturn’s northern hexagon is a 2,000 kilometer (1,250 mile) wide high-wind vortex, seen here in infrared false color. Imaged by Cassini. flic.kr/p/2g5dxDw flic.kr/p/2g4xyyQ

Great to see this study published. Congrats to Roger Daly and team! www.nature.com/articles/s41...

#Autophagy and #mTOR papers from last week, there’s always something to every taste, enjoy thanks to @Bims_BiomedNews pre-selection. biomed.news/bims-auttor/...

All-atom fixed backbone protein sequence design with FAMPNN @richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social www.biorxiv.org/content/10.1...

Our paper is out! LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share! structures| nanobodies |human immune responses | mRNA-LNP www.biorxiv.org/content/10.1...

The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...

Must read for California www.nytimes.com/2025/01/25/o...

Thanks Brett! A few more for the list re-solute.eu/resources/da... (SLCs) www.flyrnai.org/tools/fly_pr... (excellent) www.ebi.ac.uk/complexporta... prodata.swmed.edu/humanPPI/ (excellent) honiglab.c2b2.columbia.edu/PrePPI/ (unsure) predictomes.org (small target number) Any others we've missed?

Come be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...

It was perfectly clear last night until about 11pm which allowed me to finally have a good look at the Horsehead Nebula. Here is the result of 61 minutes of data (366 stacked images) from the Seestar S50. Slight enhancement in Lightroom.

New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...

High-resolution cryo-EM using a common LaB6 120-keV electron microscope equipped with a sub–200-keV direct electron detector!

Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social "I am a book I neither wrote nor read."-Delmore Schwartz

The PDBs for our TSC structure are now available! To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩 #cryoEM #mTORC1 #TSC rcsb.org/3d-view/9CE3 science.org/doi/10.1126/sciadv.adr5807 @luptoncj.bsky.social

The PDB files for the TSC:WIPI3 complex have been released today at the PDB. At 40nm across, it is well worth a look 😀🧪 www.rcsb.org/structure/9CE3

Did someone mix up AM and PM over at the #NHMRC? I'm all for releasing grant outcomes as soon as possible, but 1:30 AM is a rather unconventional choice!

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation. https://www.biorxiv.org/content/10.1101/2024.11.22.622898v1

Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex! Awesome effort from co-authors @charlesbj.bsky.social and Laura D'Andrea with @drellisdon.bsky.social doing the heavy lifting leading the project. www.science.org/doi/10.1126/...

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in Science Advances. Equal-first co-authors @luptoncj.bsky.social & Laura D'Andrea. Work lead by @drellisdon.bsky.social. Funding from @deptofdefense.bsky.social & Australian Research Council. www.science.org/doi/10.1126/...

Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪 www.science.org/doi/10.1126/...

We had a great time yesterday at the Children's Tumour Foundation Australia Conquer #NF in Colour event in Melbourne. It was great to join so many others in supporting the important work of #CTFAustralia, who advocate for and support the 1:3000 people who are diagnosed NF.

The community is growing: Metabolism Starter pack V2.0 go.bsky.app/VavECSX

The Baker lab seems serious about moving into enzyme design. Here, they train a flow-matching model that can be conditioned by atomic coordinates and then use it to design enzymes based on active site geometry specified by density functional theory. www.biorxiv.org/content/10.1...

Very exciting! Thanks to Cell Press, Arun Shukla, and the team for the Preview article on our recent advances in uncovering the structure of LYCHOS/GPR155! www.cell.com/cell/abstrac...

But here are some I use routinely. thebiogrid.org bioplex.hms.harvard.edu www.interactome-atlas.org opencell.czbiohub.org/target/1488 string-db.org depmap.org/portal/ www.interactome-atlas.org www.ebi.ac.uk/intact/ prodata.swmed.edu/humanPPI/ humap3.proteincomplexes.org

Our new preprint from Briggs lab is out! We solved the in-virus #cryoEM structure of the HIV matrix protein by SPA. The structure led us to a discovery resolving a long mystery in HIV biology – a peptide SP2 triggers the maturation of the HIV matrix domain. A 🧵 1/x Paper: tinyurl.com/c7szhtfa

Now out in NSMB for those who missed our biorxiv back in 2023.. bacterial ESCRT-III-like #Vipp1 forms dynamic spiral filaments on membrane! Spirals are springs that drive 3D ring formation in the spiral centre! 😵‍💫 wonderful collaboration with Adai Colom’s lab and @rouxlab.bsky.social rdcu.be/dZSPQ

On November 12th, we'll hear from Pavel Afonine of Berkeley Lab with an introduction to AQuaRef: Machine Learning Accelerated Quantum Refinement of Protein Structures. AQuaRef Tuesday, November 12, 2024 at 12:00pm EDT Pavel Afonine Register here: https://buff.ly/3AelDrK #structuralbiology #SBGrid

Pre-print 🚨 alert! We used AI protein structure prediction to analyze ~10,000 Borg proteins, revealing potential capsid proteins & viral-like features in these massive elements from methane-eating archaea. Could they be the first archaeal giant viruses? Check it out!

😮 Exciting study from G. Zanetti's lab exploring COPII assembly on reconstituted membrane carriers and microsomes by #CryoET: rdcu.be/dZK8M ❄️🔬

Does anyone have an up to date list of protein-protein interaction (PPI) databases? For example, Human PPI- Computing the Human Interactome, FlyPredictome etc? #AlphaFold #protein #cryoEM

Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC

Check out our new preprint on plant🌱mitoribosome! We captured it in action, translating mRNA, and combining cryo-EM 🔬 and Nanopore sequencing 🧬, identified key rRNA modifications. Plus we delve into a late-stage maturation step of the small subunit. 📖: www.biorxiv.org/content/10.1... #CryoEM

I am thrilled to share that our manuscript on using LEA proteins to prevent air-water interface damage to fragile samples for cryo-EM is officially out! #CryoEM doi.org/10.1038/s414...

Europa Clipper Launches! https://buff.ly/3Yr12to The Jupiter-bound mission seeks to discover if the icy moon contains the ingredients necessary to support life. 🧪 🔭 👩‍🔬

That was a sure thing #chemnobel