My favourite meeting of the year! Thanks @corrylab.bsky.social for organising

I am pleased to announce the release of ProteinDJ v2! This is a major update that integrates BindCraft into the pipeline as an alternative to RFdiffusion for binder generation. You can try it out here: github.com/PapenfussLab/proteindj #ProteinDJ #BindCraft #ProteinDesign @wehi-research.bsky.social

Check out our new paper: 🔗 www.cell.com/structure/fu... We explored how sulfate-reducing bacteria import isethionate, a sulfur-containing molecule found in the environment and produced by microbes in the human gut. We captured a structure of the IseQM TRAP transporter in a substrate-bound state.

Open Group Leader Positions at the IMB, UQ. Interested in joining us in sunny Queensland?

Amazing work @joshuamhardy.bsky.social and team! 👏🏻

Momentum is building! Join us for the 51st Lorne Proteins Conference Feb 8–12, 2026, Mantra Lorne on the Great Ocean Road, for fun networking activities 🏐 🎾 🥗 🪩 and breathtaking surf-coast accessibility 🏖️ 🏊 🏄 in the generous breaks between sessions! 🔗 Register here: www.lorneproteins.org/register

Researcher in Aus and want to (peak) sharpen up your crystallography skills. Then register for the upcoming Crystallography Workshop www.ansto.gov.au/whats-on/cry... #ECR #crystallography

It's #ScienceWeek here in Australia, and in an update we're doing fabulously in sending out our crystal explorer kits to primary schools over Aus and NZ. If you know a school that might like one - direct them to braggyourpattern.com/crystal-expl... today!

🥳Our 2nd CCeMMP Bench to Art gallery is now LIVE! Each submission offers a unique + creative take on research! 🖼️ Explore the gallery here: ccemmp.org/events/arc-c... And help us crown the People's Choice winner by casting your vote🗳️ #nationalscienceweek

I’m honoured to be an ACT Young Tall Poppy Science Award recipient! This award means a lot to me and I’m very excited to contribute to more science education and communication activities.

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗 🦟 Transgenic parasites without Pfs230 D13D14 do not transmit 🦙 💉Nanobodies + mRNA induced antibodies reduce transmission New in @Science.org www.science.org/doi/10.1126/... #ScienceResearch #Malaria #WEHI

Not a bad start to the week for my Masters student 🤩 🧬 🧶

Big news! 📢CCeMMP is holding the 2nd 'Bench to Art' Exhibition to showcase the artistic flair of structural biology. Share your creations to be displayed in a virtual gallery during National Science Week & for a chance to win cash prizes 💰! More info: ccemmp.org/events/arc-c... #CryoEM #Membranes

Excited to share our latest work using AI-designed proteins to block heme-piracy by E. coli. Published in @natcomms.nature.com. A team effort between my lab and the ‪‪@knottrna.bsky.social‬ ‬lab, with experimental work led by the talented @danielrfox.bsky.social www.nature.com/articles/s41...

ASBC and Biocommons are building opportunities for researchers to discuss and explore protein design tech. First up is @rhyswg.bsky.social. Excited for this!

The peer-reviewed version of our article on the flagellum filament assembly is out! A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.

Apply to join my lab neighbours! They are a great bunch 😊

Many in the #Crystallography community will remember this (and may have helped put part of it together). Our record breaking diamond structure built at the 2023 IUCr congress in Melbourne [Photo credit Jun Aishima]

Not to 'Bragg' but we have a VERY exciting project brewing and looking forward to getting the word out. Our crystal explorer kits are nearly ready for launch. Check back on Monday to find out more.... #BraggYourPattern

Feeling very lucky to be in Les Diablerets for the Mechanisms of Membrane Transport #GRC but the cute puppy updates from back home make it hard to be away!

A stunning day in Geneva!

En route to the Mechanisms of Membrane Transport Gordon Research Conference! My first GRC and first time in Switzerland

The ASBMB 2025 Conference is coming to UQ Brisbane – and the official website is now LIVE! Explore the program, register early & submit your abstract now! www.asbmb2025.com.au #ASBMB2025 #UQ #biochemistry #molbio #academiclife #conferences

We've just sent out our monthly email with the latest stories about Science and Medicine at ANU 📩 It features the RNA tech that could revolutionise cancer treatment, a dark matter lab buried 1km underground, our ANU Alumni award winners, and more. View it here: mailchi.mp/anu.edu.au/s...

Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator" www.nature.com/articles/s41...

Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2) tiny.cc/PfCRT

We're hiring!🚨Our lab is looking for two new postdocs for our drug discovery program: 1) Synthetic/Med Chem (small molecule hit-to-lead)🧪 usyd.wd3.myworkdayjobs.com/en-US/USYD_E... 2) Chemical Biology (peptide inhibitors)🦠 usyd.wd3.myworkdayjobs.com/en-US/USYD_E... Pls spread the word!🙏

1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations.. www.biorxiv.org/content/10.1101/2025.03.12.642747v1

My favourite time of year in Canberra!

Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social 🔪🎆👩‍🔬👩‍🎓

Thanks @ccemmp-outreach.bsky.social and my anonymous nominator 🥰

Celebrating Women in Science! 👏 As we prepare for #IWD2025, we're excited to spotlight the brilliant women in our centre!🥳Stay tuned for heartfelt nominations from their colleagues, celebrating their achievements and impact. We’re proud to feature them in this special series! #AccelerateAction

A global research team, including ANU scientists, discovered that an enzyme known as a ‘NUDIX hydrolase’ is used by many fungal pathogens as a weapon to cause disease in plants. The findings are published in Science. science.anu.edu.au/news-events/...

Stabilized PvRBP2b variants - wonderful collab with Sarel Fleishman 🔥Increased yields and thermal stability ✌️Maintains human mAb recognition 🩸Sensitivity as a sero-diagnostic for P. vivax 💕 Editors Pick 👨🏻‍🔬First paper for PhD student Jaison Please read & repost! www.jbc.org/article/S002...

Hello world :) #CCeMMP #cryoEM #cryoET #drugdiscovery #membraneproteins ccemmp.org

Happy to report our enzyme found a home! rdcu.be/eaGXG New kid on the block P450 O-demethylase SyoA-the specificity of a monooxygenase with the simplicity of catalysis driven by peroxide. Retrofit your P450 with this active site chemistry today! #lignin #syringol Out today in Nature Communications.

Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share! structures| nanobodies |human immune responses | mRNA-LNP www.biorxiv.org/content/10.1...

Had a fantastic time at @lorneproteins.bsky.social this week. Was great to see some @scienceanu.bsky.social ECRs take the stage to present their work! @riottowow.bsky.social @corrylab.bsky.social

Proud of our students from the Lucet Lab at WEHI who presented their posters at Lorne Proteins 2025. Well done to Dylan Silke, Emily Park, Jean-Max, and Lyn Deng! @jean-maxmazeri.bsky.social @wehi-research.bsky.social #LorneProteins2025 #LucetLab #WEHI

Light-ning Talks 🥁 sponsored by ANSTO. Alice (Jeeeun) Shin. C. albicans multi drug transporter. Cdr1 cryoEM ANU Centre for Advanced Microscopy. Asym architecture ATP sensing motif and asym mechanism. 3D prob analysis in cryoSPARC. Separate functional states for insights into transport mechanism. ⚡️

Anders ECR session Ruitao Jin: plant Ca ion channels. Mechanical gating of OSCA channels. 100s of subtypes sense and react to physical forces. Homodimers with protomer pore and cleft. Liposome inside-in structure. Membrane belt-MD avg position of lipid head group. Contribute to ion selectivity 🤩

Celebrating the Furlong lab’s 2nd birthday!

Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like “knock-kiss-kick” mechanism 🚪💋🦵 💻 by @ciarawallis.bsky.social & @riottowow.bsky.social

Our paper on the structure and evolution of baculovirus is out! Excited to share work I did at Monash in the Coulibaly lab, with big shout outs to co-authors Josh and Jungmin, collaborators Mart and team and everyone else who contributed. Definitely one of the coolest structures I'll ever work on 🤩

We’ve turned our office whiteboard into a celebration of our lab successes 🤩

Congratulations to ANU researchers Dr Alison Bentley, Dr Sarah Clement, Dr Georgy Falster and Dr Amanda Parker on being announced as new Superstars of STEM! Details: scienceandtechnologyaustralia.org.au/what-we-do/s... @raindrop-herder.bsky.social @alisonrbentley.bsky.social

Excited to share our first foray in ML-guided protein design. With the @gavinjknott lab we designed protein binders as that block heme piracy by pathogenic E. coli and potently inhibit CRISPR-Cas13. www.biorxiv.org/content/10.1..., www.biorxiv.org/content/10.1...

Pretty stoked to see the bacterial flagellar motor as the molecule of the month!

"...Australia incentivises fast research rather than slower but potentially more impactful research. EMCRs highlighted that current metrics encourage and focus on rapid results and outputs instead of longer-term or interdisciplinary work or outputs that may require a greater amount of time."