Why do I keep doing this to myself?!

MX2 Mediates Collapse of the HIV-1 Capsid https://www.biorxiv.org/content/10.64898/2026.05.07.723526v1

Latest pre-print from the lab. Superb work led by former PhD student (now senior scientist at Prosemble) Andy, in close collaboration with the Malim lab.

The structure of the Vibrio alginolyticus flagellar filament suggests molecular mechanism for the rotation of sheathed flagella pubmed.ncbi.nlm.nih.gov/42026045/ #cryoem

Very nice summary of our latest work:

Latest paper from the lab - particularly glad that we managed to get this one out, after getting scooped several times over… more spectacular work from PhD students extraordinaire, Kailin and Rosa, in close collaboration with Marc Erhardt’s group.

Our latest review on the flagellum structure: www.sciencedirect.com/science/chap...

Our paper on the in situ structure of the Tad pili machine is now published in mBio journals.asm.org/eprint/D9AT2... #microsky

Molecular basis of high-torque transmission of the Vibrio polar flagellar motor pubmed.ncbi.nlm.nih.gov/41871453/ #cryoem

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Our latest pre-print! More superb work led by duo extraordinaire Kailin and Rosa (The order of names is wrong, I should not be listed first…)

I probably shouldn’t comment on how amazing and transformative I think this work is, since I’m examining the thesis of its first author in a few weeks. So I’m not going to.

@kingscollegelondon.bsky.social spin-out company Prosemble, co-founded by @bergeronlab.bsky.social has been awarded @innovateuk.bsky.social funding as part of the Biomedical Catalyst to transform cancer care with cutting-edge nanoparticle and AI technologies. Read more: www.kcl.ac.uk/news/kings-s...

😬

That is very cool.

The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension pubmed.ncbi.nlm.nih.gov/40730569/ #cryoem

The peer-reviewed version of Sash and Iryna’s paper on the Tad pilus is out:

Hmmmm… there’s a, let’s call it “interesting” new sculpture at the entrance of the @crick.ac.uk . I’m curious to hear what this is meant to illustrate.

Superb work from our lab neighbours!

In a new study, @bergeronlab.bsky.social have used the world’s most advanced electron microscope to reveal the complete architecture of the bacterial flagellum - a molecular machine essential for bacteria to cause infection, that could also be a target for antibiotics ⬇️ www.kcl.ac.uk/news/scienti...

#NewResearch 🚨Out now! Structural analyses of the extracellular flagellum shows mechanism for flagellin incorporation #MicroSky 🦠 www.nature.com/articles/s41...

A lovely write-up from Kings about our latest paper, and its role in combating antibiotic resistance:

The peer-reviewed version of our article on the flagellum filament assembly is out! A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.

When they go low, you go high, said a very wise woman Just goes to show how pathetic Europe is exactly 💪🏻🧪 (Well done European Commission and ERC)

A family of bacterial actin homologs forms a three-stranded tubular structure pubmed.ncbi.nlm.nih.gov/40073056/ #cryoem

Latest paper from the lab: the Cryo-EM structure of BeeR! (Yes we did name the protein. No it’s not a coincidence)

Curvature generation and engineering principles from Shewanella oneidensis multi-flagellin flagellum www.biorxiv.org/content/10.1101/2025.02.07.637127v1 #cryoem

We are a little behind schedule, but the line up for the Next Great Wall Symposium in Sicily in September is coming together more soon. Get ready for those applications for abstracts!!! thegreatwall-symposium.org

First post of the year to mark my return from maternity leave :) Excited to share the first open PhD position in my group. Deadline end of February. Please spread the word. www.findaphd.com/phds/projectdetails.aspx?PJID=181239