Had a fantastic metabolism and aging retreat yesterday with the @judisimcox.bsky.social and @wiscosurgicalmetab.bsky.social labs!

With the end of the year upon us, it's time for the 2025 @lamminglab.bsky.social year in review! Some of our accomplishments and successes are described in the thread below.

Pleased to annouce the publication of our new collaboration with Spencer Haws and @johndenu.bsky.social "Depletion of individual dietary amino acids induce distinct metabolic and chromatin states"

Pleased to announce the publication of talented postdoc Dr. Yeh's new paper "Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction"!

We are excited to share our first WiSLiM manuscript! With the help of @lamminglab.bsky.social and Dr. Cholsoon Jang, we attempt to challenge the dogmatic approach to post-bariatric surgery diet with some surprising results... @wiscsurgery.bsky.social @uwhealth.bsky.social

Perhaps the most important paper of the decade with respect to how cells sense amino acid insufficiency, finally laying to rest the idea that GCN2 is activated by uncharged tRNAs!

We have a thesis defense to celebrate today, but first - we need to celebrate the publication of former student Dr. Michaela Trautman's opus, "Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice" now in Mol Metab! www.sciencedirect.com/science/arti...

Our most recent work by graduate student @mariahcalubag - demonstrating the sex-specific extension of lifespan by valine restriction was presented last week at #ARDD2025 and is now available on bioRxiv! Thanks to Daniela Bakula, @scheibyeknudsenlab.bsky.social, and Alex Zhavoronkov for the invite!

"Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease" from first author Dr. Reji Babygirija and with our collabs including @wiscosurgicalmetab.bsky.social is now available online! www.nature.com/articles/s41...

I am pleased to report our new manuscript from graduate student Mariah Calubag and collaborators and colleagues, "Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids" is now available! onlinelibrary.wiley.com/doi/10.1111/...

Pleased to announce the last major project from former graduate student Dr. Babygirija is now available on biorxiv - "Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer's disease in 3xTg mice" www.biorxiv.org/content/10.1...

Another win for rapamycin: www.nature.com/articles/s41...

Sad to learn we lost Keith Blackwell, an unsung hero of the aging field. Keith showed rapamycin extends C. elegans lifespan, that mTORC2 has diet-dependent effects on aging, and linked together skn1 TOR splicing and aging. www.legacy.com/us/obituarie...

Excited to collaborate with Caroline Alexander’s group and @lamminglab.bsky.social demonstrating the contribution of dietary lipids to skin lipids and their insulating properties. Proud of Raghav for leading this collaboration in my lab! @natcomms.nature.com www.nature.com/articles/s41...

Thrilled to have our story on the regulation of lysosomal lipids out in @cp-cellmetabolism.bsky.social! The work was led by two outstanding grad students Jess Davidson and Raghav Jain probing mechanistic control of energy expenditure @hhmi.org @uwbiochem.bsky.social

Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV

Glad to report that this tour de force from our collaborator Caroline Alexander (with a bit of assistance from our lab in the form of Michaela Trautman) is now out: "Dietary lipids are largely deposited in skin and rapidly affect insulating properties" www.nature.com/articles/s41...

New in GeroScience, "A machine learning approach for quantifying age-related histological changes in the mouse kidney" with Susan Sheehan, Seamus Mawe, Mandy Chen, Ron Korstanje & J Matthew Mahoney 🧪🤝🖥️ 🧬 #machinelearning #ArtificialIntelligence: link.springer.com/article/10.1...

Heading to the @americanaging.bsky.social meeting with @mattyousefzadeh.bsky.social and Holly Brown-Borg!

It was an honor yesterday to hood graduate student Reji Babygirija and escort her at commencement. Big thanks to the keynote speaker for our hooding ceremony Dr. Christine Whelan who gave a highly inspiring and impactful address!

Catching up on the week - awesome @AgingMidwest meeting in Rochester, MN! Congrats to @baileyknopf for a terrific talk and winning a travel award, and @iCCup_Spec for winning a poster award!

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵 www.nature.com/articles/s41...

It looks like the bill posted this morning (Saturday)-to be voted on next week-will cut the BRAIN Iniitiative and All Of Us by proposing a 69% reduction in funding for the NIH Innovation Account (CURES Act) by reducing its allocation from $407 million to $127 million. rules.house.gov/sites/evo-su...

Happy to have made a contribution to these important studies detailing the effects of dietary protein restriction on food intake, metabolism and adipose tissue in young men

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

Pleased to announce our lab's latest pre-print by graduate student Mariah Calubag "Tissue-specific effects of dietary protein on cellular senescence are mediated by branched-chain amino acids" www.biorxiv.org/content/10.1...

With the end of the year upon us, it's time for the 2024 @LammingLab year in review! Some of our accomplishments and successes are described in the thread below.

New paper! Maternal age and offspring diet interact to change reproductive timing, with consequences for fitness. #aging #gerosky #evosky besjournals.onlinelibrary.wiley.com/doi/full/10....

Trainees: Show your PIs the raw data, not just the summary result. PIs: Look at the raw data. 🤓 🧪

Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging - Nature Aging 🧪 great work from @lamminglab.bsky.social www.nature.com/articles/s43...

Pleased to announce the publication of our new manuscript, "Late-life protein or isoleucine restriction impacts physiological and molecular signatures of aging" in Nature Aging today! www.nature.com/articles/s43... Free link: rdcu.be/d1DGk

I am delighted to be able to share the latest study from the @LammingLab, “Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice” led by postdoctoral fellow @garacreen www.cell.com/cell-metabol...

Great description of @michaelamRD’s recent work at the intersection of dietary protein and metabolic health! elifesciences.org/for-the-pres...

Excited to report "Resistance exercise protects mice from protein-induced fat accretion" is out today as a Reviewed Preprint in @eLife! elifesciences.org/reviewed-pre... Paper led by grad student @michaelamRD!

Check out our new review on clinical trials of #rapamycin! A pleasure to write this with Adam Konopka and our collaborators @uwmadscience.bsky.social and beyond! link.springer.com/article/10.1...

MR evidence for potential lifespan-extending effects of mTOR inhibition and its significant influence on metabolic risk factors and disease www.medrxiv.org/content/10.1...

An entirely new paradigm for the regulation of mTORC1 is coming, addressing long-standing questions about where and when mTORC1 acts on diverse substrates. Congratulations @DemetriadesLab! www.biorxiv.org/content/10.1...

Congratulations to @LammingLab graduate student Shelly Sonsalla for receiving the UW Institute on Aging New Investigator Award!

Arrived in the Netherlands and heading to G-JAM to present our labs work. Looking forward to seeing colleagues I have not seen in person in far too long! www.g-jam.eu