Reading through the headlines these days can be a bit depressing. Having had dozens of students and staff from all over the world, there are indeed oceans of insight within Sofia Vergara's immortal words "Do you even know how smart I am in Spanish?"

I am leaving Rochester NY after attending the retirement fest of four giants in the field of evolutionary biology including my PhD advisor. This visit gave me a chance to revisit old haunts and reflect on my own somewhat unlikely origin story. 1/n

ICYMI 👉 Quantifying the fairness of polygenic risk scores: our modelling and analysis for CVD risk prediction www.medrxiv.org/content/10.1... Overall PRS fairness levels similar to or better than traditional predictors (age, sex, BP, lipids) h\t @iamslambert.bsky.social @clairecoffey.bsky.social

Wow, didn't realise it was that bad in the US (nor that the UK was that good) www.bbc.co.uk/news/article...

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Now published @nataging.nature.com: A rare sole author paper on "Refining the generation, interpretation and application of multi-organ, multi-omics biological aging clocks" www.nature.com/articles/s43...

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41... Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

It is now clear that more people are being diagnosed as autistic in their teens and as adults than in childhood. A prevailing theory is that those diagnosed later have "milder" form of autism, and later diagnosis entirely due to social factors.

Pleased to have contributed to this paper out at @nature.com today from @vw1234.bsky.social and Yira (Xinhe) Zhang showing that the common variant contribution to autism varies substantially by age of diagnosis www.nature.com/articles/s41.... Critical for understanding heterogeneity in autism.

We are deeply saddened to hear of the passing of Jane Goodall. Jane was a much-loved member of the conservation community in Cambridge and worldwide. She completed her PhD at @darwincollegecam.bsky.social and was an Honorary Fellow at @newnhamcollege.bsky.social. www.youtube.com/watch?v=ZIzR...

Staggering analysis here linking ciprofloxacin resistance to specific mutations in #Klebsiella. In short, using ONLY genotype, one can reasonably predict phenotypic CIP MICs! See Fig 3 (below). Loving the splitting of MIC and disk diffusion data as well. #AMR #MicroSky #IDSky

Let me tell you a beautiful story about this couch. 🧵 IG msviciousdesign

New Health Data Insights Podcast up! This one with Sam Lambert @iamslambert.bsky.social of PGS Catalog fame 👉 podcasts.apple.com/gb/podcast/i... Covering... -ethics of genetic prediction -risk models for diverse populations -polygenic scores in healthcare ...and being Dean of Churchill College

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

From the UK Academy of Medical Sciences & US National Academy of Medicine 👉 The ‘For people, for planet’ policy report: environmentally sustainable health research in the UK and US acmedsci.ac.uk/file-downloa... Wonderful to see www.green-algorithms.org highlighted!! ping @loiclnlg.bsky.social

Timeline cleanse. And wow, this is wonderful. www.theguardian.com/education/20...

A new large study of alcohol intake using genetics (Mendelian randomization) finds a dose-response relationship for risk of dementia with no protective effect at low levels of intake ebm.bmj.com/content/earl...

Algorithmic fairness metrics have made big inroads in the AI/ML fields to investigate model bias. A clever PhD student (@clairecoffey.bsky.social) thought, why don't you see these methods applied to CVD risk prediction or polygenic risk scores? Enter our new preprint: www.medrxiv.org/content/10.1...

✍️ New article: "How Wolbachia bacteria could help us tackle some of the world’s most neglected tropical diseases"

Delighted to finally announce a preprint describing the Q100 project! “A complete diploid human genome benchmark for personalized genomics” For which we finished HG002 to near-perfect accuracy: www.biorxiv.org/content/10.1... 🧵[1/14]

PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score... Our results were surprising... 👉 www.medrxiv.org/content/10.1...

Massive sibling regression study finds that human traits are largely environmentally driven (average heritability = 0.3)

Yup. This was me 10 years ago.

💪💪💪 www.theguardian.com/sport/2025/s...

On a personal note, it's great to have the first preprint out from my first PhD student! bsky.app/profile/clai...

Clinical statements (AHA, ESC) have suggested that PRS may be most useful as a risk-enhancing factor for those at intermediate risk. We used PRS to reclassify individuals at intermediate risk by QRISK3 and showed improved sensitivity and fairness benefits (particularly for age & sex).

We evaluated PRS in two contexts, as a standalone risk predictor and as a risk-enhancing factor. Given the known performance differences across ancestries, we were surprised to find that the fairness of PRS predictions across ethnicities was equal to or lower other CVD risk factors when used alone.

There's much more in the preprint - a great team effort from @clairecoffey.bsky.social @sritchie73.bsky.social, Lisa Pennells, Angela Wood & @mikeinouye.bsky.social all from @cambridge-ceu.bsky.social!

PRS are well know to have variable performance across ancestries, frequently with a European bias. We looked closely at fairness of PRS for CVD risk prediction, both with PRS on it's own and in an integrated risk score... Our results were surprising... 👉 www.medrxiv.org/content/10.1...

🚨 Epidemiology/Genomics PhD @cambridge-ceu.bsky.social! Fully funded 4-year MRC iCASE PhD to uncover therapeutic targets with cross-disease impact 🚀 🔗Apply by Dec 2: www.cam.ac.uk/jobs/dtp-ica... @vpd-hlri.bsky.social @dphpc.bsky.social @cambridgecardio.bsky.social Informal enquiries welcome!

Imagine a future where your medical history could help forecast what health conditions you might face. Introducing a new AI model trained on anonymised medical records that estimates long-term risk for over 1,000 diseases over a decade in advance. www.embl.org/news/science... 🧪

Exciting to finally announce the first Green DiSC awardees!

Sept is approaching & I can already hear initial chats/enquiries for potential PhD studies happening! If you're interested in a PhD, check out our department @cam.ac.uk www.phpc.cam.ac.uk/education-an... We've a super interdisciplinary faculty spanning primary care, data science, epidemiology etc

New MPhil course starting @UniversityofCambridge. Exciting opportunity for Translational Medical Research in 🔬 Translational immunology 🌍 Pandemic preparedness ❤️ Cardiovascular and respiratory biomedical research 🏥 Acute and emergency care Apply here www.med.cam.ac.uk/study/mphil-...

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

Sometimes you meet absolutely incredible bioinfo-magicians. It was a huge privilege when @shenwei356.bsky.social joined our group for a year on an @embl.org sabbatical. While here, he developed a new way of aligning to millions of bacteria, called LexicMap 1/n www.nature.com/articles/s41...

Spotify. Worst app ever.

First author @xilinjiang.bsky.social is now on Bluesky!

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read. www.annualreviews.org/content/jour...

👇👇👇 deadline for applying to this awesome opportunity is coming up on Friday Sept 12th! www.baker.edu.au/career/head-...

Can't live without The Onion's take on back to school

This is gonna be hilarious 🍿 www.cnn.com/2025/09/05/h...

👇👇👇 deadline for applying to this awesome opportunity is coming up on Friday Sept 12th! www.baker.edu.au/career/head-...

The UK's new £600m Health Data Research Service is looking for a Chair to oversee the appointment of a CEO and a Board -> micro.green-park.co.uk/hdrs/ A massive role and opportunity to transform the UK (and the world's) health data landscape...

woah this is genuinely, utterly WILD Ant queens of one species produce males of another species, so she can then mate with them and produce hybrid workers! This is so gloriously weird I can't quite compute it 🤯🧪🐜 www.nature.com/articles/d41...

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1... Very cool results: Accumulating E with age reduces heritability & PGS effects Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1... Very cool results: Accumulating E with age reduces heritability & PGS effects Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social