So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays

📢 #TOPMed e/sQTL atlas is out in @science.org today! Happy to contribute to this amazing team effort and rich resource for the genomics community: 69k cis-eQTL + 35k cis-sQTL across 6 tissues/cell types and diverse ancestries. Still more to discover 😉🧬 www.science.org/doi/10.1126/...

Very exciting new method for inferring latent disease trajectories, led by the tireless Dr. Urbut with Natarajan and Parmigiani labs. If you're considering a postdoc in this area talk to Sarah! www.nature.com/articles/s41...

Bacterial diversity and strain dynamics in the infant respiratory microbiome during the first year of life www.biorxiv.org/content/10.6... Cool study led by @gmeric.bsky.social @katholt.bsky.social @gazollavolpiano.bsky.social!

On the future of health, towards primary prevention gift link www.wsj.com/health/welln...

We're excited to have an incredible lineup of invited speakers at #IGES2026 this fall! Josée Dupuis, @mikeinouye.bsky.social, Sriram Sankararaman, and @sashagusevposts.bsky.social will present on cutting-edge topics in complex disease genetics, from multi-omics integration to biobank-scale methods.

From the referenced study: "Women were more likely to complete the PhD before age 30 and delay parenthood after 35, whereas men tended to become parents during doctoral studies and often had three or more children by age 40" link.springer.com/article/10.1...

Switzerland and the UK making the most of their participation in the EU research funding initiatives with Switzerland tied with Germany for the largest number of grants in life science.

A big welcome to bluesky to @millie-z.bsky.social! Millie is a high flying PhD student analysing whole population EHR data in England looking at the effects of air pollution+COVID19 on disease and its molecular aetiology. Worth a follow! She's also a fellow expat American here in Cambridge 😁

BBC article about Brian Ripley of the #RStats Core team given this week's excellent news concerning 2026 Rousseeuw Price for Statistics recognition for him and the core team. www.bbc.com/news/article...

The move to block the Archive from preserving the news makes zero sense. These news outlets are blocking the Wayback Machine even as they rely on it for crucial reporting… Not to mention we need fact-checking more than ever in the age of AI. www.wired.com/story/the-in...

It's mental that supplements are so unregulated. www.bbc.co.uk/news/article...

Review from the lab just out in Cell Genomics: Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging www.cell.com/cell-genomic... Co-led by fab PhD students Benedetta Felici and Siyuan Chen!

Review from the lab just out in Cell Genomics: Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging www.cell.com/cell-genomic... Co-led by fab PhD students Benedetta Felici and Siyuan Chen!

Super chuffed to see our latest preprint is out: Polygenic risk of cardiovascular disease manifests in cardiac structure and function 👉 www.medrxiv.org/content/10.6... A collaborative study led by exceptional PhD student Benedetta Felici!

Imagining Genomics and Population Health in 2050: Anticipating Future Research, Policy, and Governance Needs karger.com/phg/article/...

Haven't seen any health economic modelling of PRS for primordial prevention (i.e. intervention in early life / childhood) before... but just came across this interesting study: www.nature.com/articles/s44...

Huge congrats to @xilinjiang.bsky.social (Wellcome fellow in the group) on his first senior author paper, in @natgenet.nature.com no less! 👏👏👏👏 Pleiotropic shared heritability quantifies the shared genetic variance of common diseases www.nature.com/articles/s41...

Super chuffed to see our latest preprint is out: Polygenic risk of cardiovascular disease manifests in cardiac structure and function 👉 www.medrxiv.org/content/10.6... A collaborative study led by exceptional PhD student Benedetta Felici!

Contextualizing the Utility of Polygenic Risk Scores using Absolute Risk Models in Diverse Ancestry Populations www.medrxiv.org/content/10.6... I don't think Nilanjan is on bluesky so cross-posting his preprint (and linkedin summary) here: www.linkedin.com/posts/nilanj...

Interesting new branding

Australia is replacing coal and gas power with solar and wind— At the turn of the millennium, Australia got more than 80% of its electricity from coal. This has dropped to less than 45%. The chart shows how the country’s electricity mix has changed in recent decades.

Credit where it's due, this is a very impressive result for Oxford. www.oxfordmail.co.uk/news/2615924...

Yes and it's a scourge. www.bbc.com/news/article...

Every summer I repost this article on how to spot drowning. Please read it and pass on. In the last few years I’ve had SIX messages from people who saved a kid’s life after clicking on the link from my feed. slate.com/technology/2...

UKRI are recruiting for a new Exec Chair for Research England (£160k-£170k). It is a crucial role including QR funding and the REF. I hope they get a great field. But I worry a bit. It's hard to find on their website (see link below) fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...

"Units of the National Institutes of Health (NIH) are privately directing grantees to request permission in advance for any co-authorship with a scholar affiliated with a foreign institution...." www.science.org/content/arti...

🚨New preprint from the lab!🚨 Check @gazollavolpiano.bsky.social 's thread on our latest study looking at bacterial diversity and strain dynamics in the early-life respiratory microbiome 🫁🧫🧬👶 🔗 www.biorxiv.org/content/10.6... cc @bakerresearchau.bsky.social @uniofbath.bsky.social @lshtm.bsky.social

Across the first year, babies' airways shift from a Staphylococcus aureus–dominated state to a Moraxella catarrhalis–enriched one by 12 months. S. aureus likely comes from mum, M. catarrhalis expands as infants meet more people. Dynamics differ by strain. 4/7

For the dominant species we show who they are (strain types, serotypes), what they carry (virulence factors, resistance genes), and how they're related (phylogeny). 3/7

Early 16S rRNA microbiome studies showed broad groups only, no species, no strains, no gene content… Here, we go deeper. We sequenced 925 bacterial isolates + 142 plate-sweep metagenomes from infants across the first year of life. 2/7

New preprint! The first first-author work of my postdoc at the Baker! So, babies' airways are colonised from birth, and our group has shown that early colonisers shape respiratory health. 1/7 www.biorxiv.org/content/10.6...

Wonderful to see the new integrated OmicsPred resource now preprinted at medrxiv: "OmicsPred as a centralised resource for genetic prediction of multi-omic traits" www.medrxiv.org/content/10.6... OmicsPred: www.omicspred.org

@omicspred.bsky.social centralises imputation models from multiple resources (PredictDB, Zenodo, INTERVAL/UKB-trained scores) and multiple omics layers (transcriptomics, metabolomics, proteomics) to make analyses easier and more comprehensive, e.x. this multi-ancestry multi-omics MVP PheWAS!

Interested in applying multi-omics imputation or TWAS/PWAS approaches to your data? Frustrated by the models being spread across multiple resources? Enter OmicsPred: a centralised resource for genetic prediction of multi-omic traits! 🔗 : www.omicspred.org 📃 : www.medrxiv.org/content/10.6...

Wonderful to see the new integrated OmicsPred resource now preprinted at medrxiv: "OmicsPred as a centralised resource for genetic prediction of multi-omic traits" www.medrxiv.org/content/10.6... OmicsPred: www.omicspred.org

The insanity continues..... www.theguardian.com/business/202...

Strap in people, we're going to need to prepare for some drastic changes to how we apply for funding. Basically every funding body is being flooded with (AI generated/assisted) grant applications that are overwhelming their current systems and processes. And it's totally unclear how to handle this.

Finally! www.theguardian.com/business/202...

The Flower Moon rises over Manhattan skyline in a stunning astronomical spectacle

UK Biobank has my data, but I’m not worried. I know the benefits are too great to consider pulling out www.theguardian.com/commentisfre...

Reposting this from April 1, 2007 in honor of Craig Venter. I did this as an April Fool's joke - sharing it as a PDF. I got stressed when I found out Craig had seen it and knew it was by me. But he loved it and said it was OK to share it more widely. So then I posted it on the web.

If you're interested in the history and philosophy of randomization in all its forms I'm co-organising a *FREE* conference in glorious Bristol 2-3rd July wth the legendary Samir Okasha, registration is here www.eventbrite.co.uk/e/randomizat... If you think it looks interesting please advertise

Our new paper, led by @renatopolimanti.bsky.social and I, and published today in Nature Genetics, is the largest multi-ancestry GWAS of endometriosis to date including 1.4 million women, 105,869 cases, six global ancestry groups. Previous studies were almost exclusively European.

📣 New preprint: Plasma proteomics improves prediction of recurrent cardiovascular events www.medrxiv.org/content/10.6... Wonderful work with Yang Liu, @sritchie73.bsky.social, and many at @cambridge-ceu.bsky.social

Challenges and future directions for Mendelian randomization www.nature.com/articles/s41...

Extremely sad to hear of the passing of Icahn School of Medicine at Mount Sinai #cardiology alumnus Dr. Eugene Braunwald. His impact on medicine is immeasurable. He was a friend, mentor, and so much more. #cardiovascular #cardiosky @harvard.edu @harvardmed.bsky.social @mgbresearch.bsky.social

UK Biobank temporarily suspends access to the RAP in response to UKB data being found for sale in China www.ukbiobank.ac.uk/news/a-messa...

In other massive news, this is an immeasurable public health win www.bbc.co.uk/news/article...