Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read. They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data. Some 🤯 results 1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed

On the new acting CDC director. www.theguardian.com/us-news/2025...

The Govt. Accountability Office issued a report today finding that the Trump admin has violated a law blocking presidents from withholding funding Congress has approved @mmolteni.bsky.social & I break it down: www.statnews.com/2025/08/05/g...

Every reputable expert I know considers mRNA vaccine technology to be one of the most revolutionary advances in medicine in our lifetimes. Its inventors won the Nobel Prize in 2023. Shutting it down now is pointless self-harm to humanity.

Let’s not pretend this ends with Harvard. This will be every American university unless a resounding legal win establishes precedent

Incredibly well reported deep dive on NIH and health disparities research in STAT. 🧵 www.statnews.com/2025/08/01/n... 1/31

The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com. The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH. Prelude to rescissions, especially after his comments over the weekend?

Wonderful tribute to a dear colleague- well worth the read www.ucsf.edu/news/2025/06...

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9

🚨 BREAKING: Nearly 4 months the NIH cut its first grants, a judge has ruled that the directives and process that led to cuts are arbitrary and capricious. "The explanations are bereft of reasoning — virtually in their entirety... unsupported by [facts]." Each of them are VOID and ILLEGAL, he says.

"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!

"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...

Now published! Congrats Yon Ho on this huge lift conducting dozens of GWAS in Korea and performing meta-analyses with other Asian biobanks reaching a sample size comparable to UK Biobank. The fine-mapping, novel loci, and ancestry-enriched discoveries are very cool. www.nature.com/articles/s41...

Statement from the American College of Obstetricians and Gynecologists

America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.

🚨This is a HUGE escalation and a deliberate effort to use the government against Trump's enemies. Weaponizing the Student and Exchange Visitor Program certification against Harvard to punish them for pushing back is a new low — and needlessly punishes thousands of innocent students.

The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.

She’s out!! They have released Ozturk from ICE custody!

And just today the EIC of Nature Neuroscience told me in public that they are a for-profit company and if they had to pay reviewers they would "need" to raise prices.

Breast cancer diagnoses rose by over 300% between 1973 and 1992. Was there a breast cancer epidemic?! NO. Mammograms were implemented for screening in 1976. PREVALENCE is a function of being able to correctly diagnose something. This is also about autism.

I've received additional confirmation, as well as an email I can share publicly. See the directive NIH grants management staff received from Michelle Bulls, director of extramural policy at NIH:

🚨 PGC Africa Monthly Meeting Alert! We are delighted to have Dr Lerato Majara from the Martin Lab @genetisaur.bsky.social, @broadinstitute.org join our 3rd virtual meeting of 2025 📆 24th April 2025 ⏲️ 2PM GMT | 2PM WAT | 3PM CAT | 4PM EAT 📢 More details on the flyer below #Psychosis #Africa #GWAS

Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu

BREAKING: Last night, the Harvard faculty chapter of the AAUP and the national AAUP filed a lawsuit & TRO to block the Trump administration from illegally demanding that we keep quiet and change how we teach and research at the point of a financial gun. actionnetwork.org/user_files/u...

A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org www.nejm.org/doi/full/10....

How many of these are in blue states you ask? 🙄 Turns out, it was never about “antisemitism” or they would have ousted the Nazi billionaire gutting the government’s functionality while somehow also wasting $ www.ed.gov/about/news/p...

So we’re 75 days into trumps second term, people are protesting everywhere. Markets have had two days of absolutely apocalyptic losses. There are grad students being disappeared and a man with an autism awareness tattoo was sent to a super scary prison in El Salvador. They’ve cut cancer research..

“Harvard now faces one of the most consequential choices in its history: Submit to extortion and make itself complicit in the most profound assault on academic freedom and constitutional governance of our time—or go to court. The stakes are high, but the choice should not be difficult.” (Fixed link)

New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process 1/n

BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants. This is an unlawful attack on scientific progress that puts lives at risk.

Our OnSIDES db -- the worlds most up-to-date resource of drug side effects is published at @MedCellPress For all your drug safety analysis and prediction needs. OnSIDES is the first resource to combine US, UK, EU, and Japanese data all in one place. www.cell.com/med/abstract...

“Dr. Richard Youle, a leading researcher in the field of neurodegenerative disorders…including identifying mechanisms behind Parkinson’s disease” was one of several top scientists PURGED from the NIH today courtesy of Trump/Musk/DOGE. www.wired.com/story/doctor...

Massive turnout in solidarity with Rumeysa Ozturk, a Tufts graduate student who was abducted from a Somerville street by Trump’s government - Somerville stands with Rumeysa

This arrest is the latest in an alarming pattern to stifle civil liberties. The Trump admin is targeting students with legal status and ripping people out of their communities without due process. This is an attack on our Constitution and basic freedoms — and we will push back.

The Tufts graduate student detained by federal authorities in Somerville has been sent to a Louisiana detention facility, despite a federal judge’s order telling US Immigration and Customs Enforcement not to remove her from Massachusetts without notice.

Just found out NIH has officially canceled our grant, a longitudinal study of Alzheimer's disease in Black Americans. I cannot even put into words how angry I am. The truth is they are canceling it because it has Black in the title. That's it, there is no other reason to do this.

This is excellent; a very clear explanation of what’s at stake at Columbia.

UCL is a fantastic place to work, London a great city to live in, in the UK. From the UCL Genetics Institute (UGI) we are happy to support applications to work on genetics and genomics of populations, broadly speaking. www.ucl.ac.uk/biosciences/...

How many Columbia PIs who lost grants are Jewish? This isn’t about antisemitism. How many Penn PIs know the name of the trans swimmer who followed all the rules to swim on their team in 2022? This isn’t about gender minorities. It’s about destroying universities and hushing dissent. Who’s next?

It looks like councils are on the federal register now, @jeremymberg.bsky.social!

I now have multiple sources that say at least one round of NATIONAL ADVISORY COUNCIL MEETINGS will now be announced in the Federal Register.

STAND UP FOR SCIENCE SPEAKER ANNOUNCEMENT! ☀️ Dr. Francis Collins will be speaking at Stand Up for Science in D.C. on March 7th! More speaker announcements coming soon, stay tuned! 👀☀️

In an unprecedented move, the US National Institutes of Health (NIH) has begun mass terminations of research grants that fund active scientific projects because they no longer meet “agency priorities”…. 🧪 #AcademicSky www.nature.com/articles/d41...

In his confirmation hearing now, Bhattacharya was asked by Senator Cassidy whether he thinks there's a need for NIH to study the myth that vaccines cause autism. Bhattacharya says he doesn't believe there's a link, but leaves door open to wasting taxpayer money & scientists' time relitigating this.

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

What are your favorite methods for dissecting pleiotropic relationships, especially directly (with effect size estimates from GWAS across multiple traits) or alternatively, via latent variable approaches? Reviewing this space and hoping not to miss important contributions