Suomen talouden korjatut kasvuluvut osoittavat entistä selvemmin, että Orpon hallitus on onnistunut tuhoamaan suomalaisia työpaikkoja tuhatmäärin keskellä vahvaa suhdannetta. #talous #politiikka

The proposed cap, and to some extent the current limit to 6 proposals per FY, dismantles MPI science. Less collaboration will be the result.

I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...

NIH grants have been under political scrutiny since early 2025. But what does the screening process actually look like? What is being flagged? I spent a month digging into leaked docs and emails. We've published the 235-word list that are being flagged by an internal AI tool. And so much more. 🧵

Arvoisa sosiaali- ja terveysministeri Wille Rydman. Poliitikkojen tehtävä ei ole ohjailla, mitä saa tutkia. Heidän tehtävänsä on varmistaa, että tiede saa riittävät ja vakaat resurssit. tieteentekijat.fi/poliittinen-...

We regret that our event on Extreme Heat: Improving governance and strengthening action around the world has been cancelled due to the red extreme heat warning issued by the UK Met Office. Our apologies to everyone who was planning to attend the event.

Unpopular opinion: Going straight to AI limits your creatively, because it short-circuits the iterative process you need to develop new ideas.

A unique job opportunity to work on some of the most exciting genomic datasets in the world!

Happy to share that this work led by @mihkeljesse.bsky.social has now been published at PLOS Genetics! journals.plos.org/plosgenetics... A couple of thoughts below.

🏆 Congratulations to Tuuli Lappalainen, ESHG Award Lecturer 2026! In her Award Lecture, Professor Lappalainen will discuss the next steps in interpreting these effects and the tools that will help researchers uncover the molecular mechanisms underlying genetic variation. #Genetics #eshg2026

Next up, Adam Ameur shares that long-read WGS efforts are ongoing in Sweden for population genomics and clinical diagnostics. They bridge these projects by using a joint analysis framework and shared variant databases. #ESHG2026 #PacBio #ESHG

New Yorkers singing Empire State of Mind

To all attending #eshg2026: if you are ready to spent extra attention to detail throughout the entire conference, I recommend the informal ESHG bingo card. Brought by our great postdoc @lydiasagath.bsky.social @eshg.bsky.social First bingo gets a kanelbullar from me… tinyurl.com/eshgbingo2026

🚀 #EASIGEN-DS is heading to #ESHG2026 Join us at the 59th ESHG conference that brings together leading experts across the field for four days of intensive collaboration!🧬 🏆 Don’t miss the ESHG Award Lecture by @tuuliel.bsky.social, our WPs leader, who has been honored with this year’s award

Petteri Orpo pyysi katsomaan tuloksia. OK, tehdäänpä niin. 1/4

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

We are gliding serenely towards the worst El Niño in recorded history as Iran War hamstrings food industries across the globe

We built a joint experimental and computational platform for scalable multi-modal single-cell chemical screens — profiling RNA, protein (including phospho-signaling), and chromatin accessibility responses to thousands of small molecule perturbations in parallel. www.biorxiv.org/content/10.6...

It’s truly astonishing to see how comprehensively the US government is tearing down every part of the system that has made it up until now a world-leading power in science, research, and technological development. The entire world will suffer from this wanton destruction.

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

OpenSplice: the impact of half a million mutations on the alternative splicing of 600 human exons https://www.biorxiv.org/content/10.64898/2026.05.22.727141v1

'Some policy directives go further. An email from NIH’s NIGMS to research-center grantees, seen by Science, requires their institutions to promise that U.S. authors of papers NIH has flagged because of foreign co-authors will not collaborate with them in the future.'

Some thoughts on where AI in genomics stands right now, building on a symposium we recently hosted at UChicago. Seven points, ranging from why scaling DNA models hasn't delivered, to why metadata is the real bottleneck, to the weird backlash against AI in academia open.substack.com/pub/blekhman...

While BioNtech & Moderna become household names because of their Covid vaccines, those emerged from different projects: finding ways to treat the most challenging cancers. They hypothesized that we could vaccinate patients against their own tumors, & evidence is mounting that they were right! 1/n 🧪

I just did an 18-part X thread that starts below, too tired to copy paste it all for BlueSky but if someone would do that I would be appreciative

If you want to know what 3′UTRs with long conserved sequence stretches do, check out our BioRxiv preprint doi.org/10.64898/202.... They form functional intermolecular 3′UTR-3′UTR interactions that enable co-folding of proteins to rapidly induce transcriptional programs.

#MLCB2026 will be November 16-17 at (once again) @nygenome.org, NYC! Paper/abstract deadline is July 1st, more deets at mlcb.org. We'll be opening in-person registration alongside paper decisions. Mailing list to stay in the loop: groups.google.com/g/mlcb. Keynotes TBA! Please RP!

Super excited to see this out! Fantastic collaboration with Luke O'Connor and trainees Amber Shen and Xinran Wang. Thread with details will come soon, but linear ARG provide a HIGHLY efficient representation of genotype data that can be treated as a linear operator www.biorxiv.org/content/10.6...

New preprint on a controversial topic: Through which socioeconomic mechanisms do individuals with higher genetic predisposition for educational attainment end up with higher income over their working life? We study this using uniquely rich Finnish data.

Some useful public speaking tips from Freud here.

Bioconductor 3.23 is released! Thanks to the core team for all the hard work that goes into a release, and to the package reviewers. The lab has a bunch of updates in here that I'll post in 🧵 over the next few days:

New York Times article about the slow pace on NIH grant making as well as enforcement of political constraints. [Gift Link] www.nytimes.com/2026/04/22/s... 1/4

Very informative post from Elizabeth Ginexi about NIH grant delays. elizabethginexi.substack.com/p/the-execut...

Stunning illustration of how advances in cellular genomics can disentangle links between gene variants & clinical outcomes. Here, saturation editing revealed distinct neurodevelopmental disorders involving the same non-protein-coding gene. 🙌 @nickywhiffin.bsky.social @gregfindlay.bsky.social & co🧬🔬🧪

📣Registration and abstract submission now open for the Long‑Read Sequencing Uppsala 2026 meeting, taking place November 2–4! For abstract submission, registration, and the preliminary program, please visit the conference website: 👉 lrua.se

”Nykypäivänä onkin varsin selvää, että vihreät ja globalisaatiokriittinen vasemmisto olivat oikeassa. Vapaakauppa ilman yhteiskuntavastuuta oli juuri niin tuhoisaa rauhalle, vakaudelle, sosiaaliselle oikeudenmukaisuudelle ja ympäristölle kuin mistä varoitettiin.”

The 5y survival rate for pediatric ALL in 1970 was under 20%. Today it is over 95%. Modern cancer treatment is the result of a lot of dedicated scientists rowing together to save people they have never met, and fuck anyone who says otherwise.

@nygenome.org is hiring Genomic AI Fellows! (fancy postdoc positions) If you're interested in working at the interface of AI and genomics in a great environment please apply at: jobs.silkroad.com/NYGenome/Car...

This. A thousand times this.

One year during our Columbia PhD program recruitment day there was a total subway meltdown with half the the faculty stuck in tunnels, missing their scheduled meetings.

Happy and honored to receive the 2026 ESHG award! Many thanks to past and present lab members and collaborators; it’s our work together that is recognized here. See you at the @eshg.bsky.social meeting in Gothenburg 🇸🇪 in June!

👀 Absolute banger paper. Leveraging cattle/pig GWAS/eQTL to help explain the missing regulatory gap in humans. Consistent with previous works, selection makes identifying relevant eQTLs in humans challenging. www.biorxiv.org/content/10.6...

Sweden continues major investments in research and life science, with more KAW foundation funding for trainee positions in the Data-Driven Life Science Program, with total investment of 330 MEUR / 380 MUSD!

On Monday, Johan Rockstrom spoke at PBL in The Hague. His presentation was perfect, the science well explained. It’s bad, worse than we think (as usual), we need to take measures, it can be done, tipping points, acceleration of acceleration, food systems, move away from fossil fuels. Questions from

Junk RNA

Democratic consultants: To replicate Mamdani’s success with the young people we must appeal to their short attention spans with memes and TikTok Mamdani (actual quote): In the fifth century in what we now know as Ireland, a British warlord named Coroticus had laid waste to the countryside

I am reviewing a simply amazing paper from a relatively young US-based lab, which is in danger of shutting its doors later this year. My emotions are all over the place. The fact that this does not uniquely identify the lab I’m referring to just deepens the tragedy of this moment in US science.

Every day is a good day for sharing one of the most useful papers about research data ever written. PLEASE get your people to understand and follow this advice. www.tandfonline.com/doi/full/10....

Happy St. Patrick's Day, New York.