Reminder that the abstract deadline for the Biology of Genomes meeting at CSHL is on Feb 13! We have a fantastic lineup of keynote speakers (Janet Kelso and Jonathan Pritchard) and session chairs. Submit your best science to this exciting and engaged meeting! meetings.cshl.edu/meetings.asp...

🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

The lesson for all the students out there is that science is a community project. Most of us make individually small contributions to this project. Success is measured at the collective level. Many of our professional (and personal) dysfunctions could be fixed by more fully embracing this view.

Please share this with your network: Postdoctoral position available in my group. www.linkedin.com/jobs/view/43...

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...

I think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.

I started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.

Kohta paljastuu kaikille, että hyvinvointivaltio tukikin rakenteellisesti taloutta ja talouskasvua, jolloin sen romuttaminen oli onneton rakenteellinen uudistus negatiivisin pitkän aikavälin vaikutuksin. Kiitos! #talous #politiikka #yhteiskunta

Nature and Science journalists denied entry to event featuring NIH Director

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

Because of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5): grants.nih.gov/faqs#/common...

RFKJr's principal accomplishment as the nation's health guardian.

A want new mandatory course in school curricula worldwide: Everyday logistics in urban environments. Content: How to exit the subway. How to enter the subway. How to move in stairs. How to queue.

WHO removing Us Flag

NEW | Wind and solar generated more power than fossil fuels in the EU for the FIRST time ever. 🌪️ and ☀️ made up a RECORD 30% of 🇪🇺 electricity, up from 20% just five years ago. https://ember-energy.org/latest-insights/european-electricity-review-2026/

The interesting applications of AI are all, like, "we built an open framework that uses processors on recycled cell phones to identify and triangulate the location of rare bugs in tropical rainforests" while big tech is going "what if we burned down that rainforest to summarize your emails?"

Lunchtime panel of faculty experts on Venezuela and oil politics in one of our larger event spaces on campus was standing room only today. Packed with students, faculty, community members. Makes me wonder why we aren’t doing teach-ins like this every week.

Trump has been in office for one year. We at @nature.com did a deep dive looking at the administration's disruption of science in numbers. Take a look—the numbers are staggering. By me, @dangaristo.bsky.social, Jeff Tollefson, @kimay.bsky.social, & help from @noamross.net @scott-delaney.bsky.social

I just woke up from a nap and somehow while I was asleep, everyone on the bus has figured out we are not going to the right place

New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.

SciLifeLab PULSE postdoc program focuses on innovative, fundamental, translational research. "The entrepreneurial track sparks the next generation of life-science ventures based on ground-breaking research at universities” says Kristian Sandberg. 🧪🌍 Apply today! www.scilifelab.se/news/pulse-p...

My specific experience is with NIH, but I’ll stand up and say it: The people who work at NIH are together one of the great wonders of the world. US biomedical science, cancer cures, dementia research all are built on their talent and dedication.

1,000 PacBio genomes in a prospectively designed clinical utility study. This was the biggest and most important study that made us go live in diagnostics. Long-read genomes as a genetic first tier test across many rare diseases! www.medrxiv.org/content/10.6...

A long, absolutely must-read article from Cory Doctorow: www.theguardian.com/us-news/ng-i...

very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...

Full survey results show American public have high levels of confidence in scientists while revealing some partisan differences (including on how to fund science), but statements asserting lost trust should be read instead as intentional efforts to degrade trust. www.pewresearch.org/science/2026...

Tha'ts what scientists want too. We need AI that makes sure you don't break the dishes (or centrifuge)

Just astonishing good news. We are on the way to end Multiple Sclerosis. University research delivers. Always has. Now a cabal in the White House is shattering it.

I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!

TL;DR: Indirect costs as a percentage of total costs - like the private sector tends to calculate it - for NIH grants is typically around 30-35%.

Interpretable inflammation landscape of circulating immune cells @naturemedicine.bsky.social @fcraighero.bsky.social @hoheyn.bsky.social @dmaspero.bsky.social @saguilarfer.bsky.social@broadinstitute.org @cnag-eu.bsky.social www.nature.com/articles/s41...

do they realize proteins come from mRNA?

ICYMI in the mad rush before the winter holidays, we published a paper looking at integrated risk prediction of cardiovascular disease and modelling both targeted and population-wide intervention in the UK. I was honestly surprised at the potential benefits 👇

Wow! 167.2 Gb HiFi yield from a PacBio SMRT cell🎉 Are we getting close the record? This run was for the “Genome of Sweden” project, where we're building a national reference dataset from 10 year old biobanked DNA samples🧬🧪

BIG FIGHT AT POLAND’S WROCLAW ZOO!!!

"Illumina Appoints Former NHGRI Director Eric Green as Chief Medical Officer" www.genomeweb.com/sequencing/i...

🔬 pertpy: a unified, scalable framework for single-cell perturbation analysis, now out in Nature Methods Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions. 👉 www.nature.com/articles/s41...

Breaking News: Gov. Kathy Hochul, partnering with Mayor Zohran Mamdani, will unveil a plan to expand free or affordable child care for New Yorkers across the state.

Happy new year/paper! A new tech (scG2P) maps genotype (DNA) to phenotype (RNA) in single cells, bringing together the worldviews of genetic & transcriptional heterogeneity. With scG2P we define how mosaicism drivers increase clonal fitness in the aging esophagus aacrjournals.org/cancerdiscov...

The U.S. Congress has delivered another rebuke of President Donald Trump’s plans to slash this year’s budgets of several science agencies. https://scim.ag/49G7Zwe

If you like larger sample sizes, then do check out our reprocessed and fine mapped cis-eQTLs and cis-sQTLs (leafCutter and MAJIQ!) from the INTERVAL cohort (whole blood, n up to 4,729)! zenodo.org/records/1795... These will be on the eQTL Catalogue FTP soon as well. cc @yosephbarash.bsky.social

Excited to see this out www.nature.com/articles/s41...! Nonparametric kernel-based tests for spatially variable isoform usage in spatial transcriptomics. So many interesting examples in the CNS and cancer, we're only scratching the surface!

The district court injunction that prevented NIH from capping indirects at 15% was upheld today on appeal! www.reuters.com/world/trump-...

How well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS. In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time! doi.org/10.64898/202... 1/n

Integrating perturbational screens, eQTL, and GWAS data identifies mediating genes for complex traits https://www.medrxiv.org/content/10.64898/2026.01.05.26343421v1

🔴 Nordic nations signal support for Denmark as Trump threatens Greenland amid Venezuela regime-change push In a telephone interview with The Atlantic, US President Trump said “We do need Greenland, absolutely. We need it for defense.” He claimed Greenland’s strategic location matters for...

Krugman väänsi rautalangasta jo 10v. sitten miten tämä "tuntematon jarru" toimii, mutta kukapa nyt nobelistia kuuntelisi kun voi mieluummin uskoa uusliberaaleja satuja. www.theguardian.com/business/ng-...

Mamdani: For too long, those fluent in the good grammar of civility have deployed decorum to mask agendas of cruelty