📢I'm setting up a new team at the @humantechnopole in Milan. We have several openings in AI applied to nationwide health data, biobank-scale -omics. Milan is a beautiful city and at @humantechnopole is top notch. You can find post-doc positions here: careers.humantechnopole.it/job/Postdoc/...

FIMM is joining forces with @ellisinstitute.fi to launch the FINe-Health Foundry project aiming to build the world’s first nationwide healthcare foundation model. The project has received ~€5M in Business Finland's Rise to Challenge funding. @andganna.bsky.social www.helsinki.fi/en/hilife-he...

MSc Lisa Eick from @andganna.bsky.social's group will defend her doctoral dissertation "Improving Cross-Biobank Genetics Through Phenotype Refinement and Machine Learning" @helsinki.fi on 29 May at 13:00. Opponent: Associate Prof Sandra Sanchez-Roige (UCSD) 🔗 tapahtumat.helsinki.fi/en-FI/page/6...

New preprint on a controversial topic: Through which socioeconomic mechanisms do individuals with higher genetic predisposition for educational attainment end up with higher income over their working life? We study this using uniquely rich Finnish data.

New preprint 👇 Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery? We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery. Led by Lisa Eick & Zhiyu Yang!

This week on The Genetics Podcast, @andganna.bsky.social joined host Patrick Short to discuss advances in genetics and data-driven medicine, including the the promise and limits of polygenic risk scores for disease prediction and clinical trials. 🎧 podcasts.apple.com/fi/podcast/e...

🚨New preprint out Mapping real-world statin adherence at population scale (doi.org/10.64898/202...) We analysed >1 million long-term statin users in Finland and Italy (Lombardy), identified adherence patterns, and examined baseline factors associated with declining adherence.

New preprint 👇 Does diagnostic misclassification in EHR-based psychiatry GWAS suppress genetic discovery? We use simulations and FinnGen data to expand the SuperControl framework and propose a new ML approach (PRISMA) to boost signal discovery. Led by Lisa Eick & Zhiyu Yang!

🌟 Applications for the 2026 Leena Peltonen School of Human Genetics are open! Back after a great 2025 edition: ~20 global leaders and ~20 PhD students shaping the future of genomics. 📅 July 26–30, 2026 📍 Wellcome Genome Campus, UK 📝 Apply by March 6 → www.lpshg.com

🌟 Applications for the 2026 Leena Peltonen School of Human Genetics are open! Back after a great 2025 edition: ~20 global leaders and ~20 PhD students shaping the future of genomics. 📅 July 26–30, 2026 📍 Wellcome Genome Campus, UK 📝 Apply by March 6 → www.lpshg.com

— Genetiikka vaikuttaa persoonallisuuteemme, ja persoonallisuutemme vaikuttaa siihen, mitä opiskelemme. Voimme nyt havaita näitä yhteyksiä selvemmin suoraan DNA:stamme, sanoo @andganna.bsky.social. Linkki Nature Genetics -lehdessä julkaistuun tutkimukseen: www.nature.com/articles/s41...

Jakob German from @andganna.bsky.social's group @hilife-helsinki.bsky.social will defend his doctoral dissertation "Genetically-Informed Real-World Evidence and Trial Design on 12 Dec. Linda Kachuri, Stanford University, will serve as the opponent. Welcome! 🔗 tapahtumat.helsinki.fi/en-FI/page/6...

1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...

Happy to have contributed to this study! Our personality and behaviors, as captured by genetic markers, also influence what we end up studying and, eventually, our professional careers

EU vice-president Virkkunen launches RAISE: resource for AI science in Europe. Not exactly clear what this entails. But i understand: more money, more networking.

Yoshua Bengio and the role of EU in AI development

Are you in #Boston for #ASHG25? Come by and check out my poster (#1023) today from 2:30–4:30 PM. Would love to connect and discuss about it :)

🎉 New preprint out! "Removing genetic effects on plasma proteins enhances their utility as disease biomarkers" We show that adjusting plasma proteins for genetic effects can make them stronger predictors of disease 👉 doi.org/10.1101/2025...

Very important paper for the geroscience hypothesis. Healthy aging is critical, even in the face of obvious disease states.

💥 New preprint & our first RCT! 💥 Does an extremely high or low BMI polygenic score influence weight loss after a diet intervention? GENEROOS is a 6-month randomized diet vs. control trial testing if genetic predisposition to higher BMI affects weight loss in overweight adults

A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new study in Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting progression • Lifespan PRS predicts survival better

“Towards modeling evolving longitudinal health trajectories with a transformer-based deep learning model” in collaboration with Pekka Marttinen at @AaltoUniversity www.sciencedirect.com/science/arti...

If you are interested in our pilot use of cross-EU health data ahead of the European Health Data Space implementation, check this out pubmed.ncbi.nlm.nih.gov/40926479/

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

Cool work from @ewanbirney.bsky.social Moritz Gerstung, Tom Fitzgerald about modeling health trajectories with generative AI! www.nature.com/articles/s41...

Some people call it a minefield. Others call it dangerous, even irresponsible. I call it the most promising field in life sciences. My love letter to social science genetics: communities.springernature.com/posts/a-love...

Check out @tuomohartonen.bsky.social blog post on our study, out today in Nature Genetics, comparing electronic health record-based risk scores with genetic polygenic scores, and how they work better together! tuomohartonen.substack.com/p/medical-re...

Are electronic health records (EHR) more predictive of disease onset than polygenic scores? Can we transfer EHR-based prediction models between countries? Our study on these questions using 3 biobank-based studies with N>845K, is out in @natgenet.nature.com today: www.nature.com/articles/s41...

Happy to see this online! Having an extra sex chromosome really challenge the binary definition of sex based on XX and XY. So it is not only a medical, but also an important societal question.

Impressive paper by EPIC. They built a autoregressive transformer on 150M individuals and 115 billion medical events. Including: diagnoses, medications, lab values, procedure Cons: model is not shared (and unlikely will be) arxiv.org/pdf/2508.12104

Papers of the months in Health Data Science healthdatascience.substack.com/p/monthly-up...

The iPSYCH study represents a unique example to understand the ethical and legal challenges of using existing samples/data for health research. A thread 🧵 www.science.org/content/arti...

Dived into past, present & future of human genetics with brilliant students & mentors.Grateful for the chance to present my work on personalized sequence→expression prediction and discussions with @sashagusevposts.bsky.social @bpasaniuc.bsky.social @mashaals.bsky.social @tuuliel.bsky.social & others

This was such a special event! So grateful that I could be part of it, learning about great science, making truly unique connections with amazing fellow students and tutors, and even learning how to punt 🛶 Huge thanks to everyone who helped bring this unique school back to life!

It was a pleasure to be part of this summer school. Students were amazing, it was a great experience getting the chance to discuss one on one without hierarchy for three days with them. They taught me so much.

Truly grateful for the exceptional opportunity to participate in #LPSHG2025 last week, featuring a stellar ✨ lineup of leading researchers who doubled as tutors, alongside inspiring fellow PhD students. Excited to apply my learnings and see where this collaborative spirit takes genomics next!

Great meeting! Renewed excitement about all the cool research happening in genetics right now 🧬

The pace and breadth of discovery are mind-blowing and made even better by the cool people involved. So grateful to have taken part in this event 🙏 Now to process it and try to apply a tiny fraction to new research projects

Leena Peltonen School of Human Genetics in full-swing! @gosiatrynka.bsky.social @dgmacarthur.bsky.social @bpasaniuc.bsky.social @tuuliel.bsky.social @hilarycmartin.bsky.social @sashagusevposts.bsky.social @zkutalik.bsky.social @mashaals.bsky.social @alemedinarivera.bsky.social

🇪🇺 The European Commission R&D website has highlighted our ERC-funded work on AI for health data. This is a part of a larger effort to highlight how EU-funded AI research has enabled innovation and discoveries in life sciences. cordis.europa.eu/article/id/4...

Can we use genetics to make real-world evidence more like randomized trials and improve trial design in the process? In our latest paper, we emulate 4 cardiometabolic RCTs in FinnGen and test how polygenic scores can improve trial emulation rdcu.be/eryti

Ely Lilly buys Verve therapeutics www.investors.com/news/technol...

New preprint: One of the largest studies (N = 67,000) on how sexual desire varies with age, sexual orientation, education, job, number of children, recent birth, and relationship satisfaction, and how the trends differ by gender. doi.org/10.21203/rs....

The FIMM Young Investigator for April 2025 is Feiyi Yang, a doctoral researcher supervised by @andganna.bsky.social & Tiinamaija Tuomi. Warm congratulations to her for her recent 1st-author publication on the effects of parental autoimmune diseases on type 1 diabetes in offspring in Cell Genomics!

If you are seriously considering an academic career in Europe, and you are weather hardened by the mid-west or north east, this is an amazing opportunity!

We have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data        Generous starting package 💰 shorturl.at/FAk6n

Matteo Ferro, a doctoral candidate in my team has a new blog on health data science where he is collecting the most interesting papers, each month. Check it out!                healthdatascience.substack.com

It's #eshg2025 #eshg25 time 🥳 Here is where you can catch the team over the next few days. Please go and say hi!