Urinary Single-Cell Transcriptomics in Kidney Transplantation: Elucidation of Donor–Recipient Cellular Dynamics and Fibrogenic Stress www.sciencedirect.com/science/arti...

🧬 New preprint: "The Human Pleiotropic Map of GWAS Associations and Therapeutic Implications" Why do some genetically supported drug targets succeed in the clinic while others fail? Across 100,526 GWAS, the same evidence flags constrained gene functions rarely safe to modulate.

Amazing what Claude AI is capable of, together we wrote this paper: Genomic correlates of hyperthermostability revisited: a large-scale validation across 1,963 microbial genomes 2026 Claude AI written: www.biorxiv.org/content/10.6... 2003 Suhre & Claverie, JBC paper: www.jbc.org/article/S002...

Interesting paper on the genetics of familial hypercholesterolaemia using WGS of 77,260 samples. jmg.bmj.com/content/63/5... I find the large number of variants in LDLR particularly interesting for further investigations into the structural factors of LDLR - APOB interactions.

Come and join me for a GenomeWeb webinar supported by Seer on "Unbiased Plasma Proteomics Expands GWAS Insights" Wednesday, March 11, 2026 12:00 PM Eastern Daylight Time Register here: event.on24.com/wcc/r/521498... More details: www.genomeweb.com/events

Using @somalogic.bsky.social affinity #proteomics data from three cohorts and #pQTL association strength as a readout we identify protein signatures reflecting latent variation in aptamer-based affinity proteomics. Learn how HSP90 can act as a proxy for cell-lysis. pubs.acs.org/doi/full/10....

Quantifying the ∼75–95% of Peptides in DIA-MS Data Sets that Were Not Previously Quantified #JProteomeRes pubs.acs.org/doi/10.1021/...

Our paper is now available in the print edition of Proteomics: "Comparative Analysis Between Olink-PEA and Alamar-NULISA Proteomic Technologies Applied to a Critically Ill COVID-19 Cohort" dx.doi.org/10.1002/pmic...

A study on 1.7 million people in Hong Kong shows superior hybrid immunity to Covid in people who got vaccinated before infection vs. people who got infected first. "Our findings are a direct rebuttal to arguments for natural immunity," the authors write. doi.org/10.1016/j.va...

Here a tutorial on how to easily 3D-print proteins and other macro-molecules: makerworld.com/en/models/96...

Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome. By integrating faecal metabolomics, metagenomics, and dietary data Falchi et al. show that faecal metabolites capture mediations between diet and the gut microbiome www.nature.com/articles/s41...

Read our latest paper just published in Nature Genetics : A genome-wide association study of mass spectrometry proteomics using a nanoparticle enrichment platform www.nature.com/articles/s41...

Honestly - these days the most interesting part is often the exchange with the reviewers - great idea to make these public: our paper has 67 pages, they can be found here: static-content.springer.com/esm/art%3A10...

Suspense ! Our new #GWAS with MS #proteomics paper has been scheduled for publication in Nature Genetics on 27 November 2025 at 10:00 (London time) and will be available at the following URL: www.nature.com/articles/s41...

Genomics of drug target prioritization for complex diseases - a Nature Reviews Genetics review: www.nature.com/articles/s41...

Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of Diabetes: www.niddk.nih.gov/about-niddk/...

Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming. Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15... citing our #Qatar study with @metabolon.bsky.social data: www.cell.com/cell-genomic...

“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM. news.weill.cornell.edu/news/2025/10...

🔬Inside the Core Lab: Driving Discovery in #Proteomics Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs. Featured in the lead-up to #QPC2025 — where innovation meets collaboration.

This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff. www.niddk.nih.gov/about-niddk/...

A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...

October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon. www.lipidmaps.org/updates/lipi...

"A standardized framework for circulating blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects www.nature.com/articles/s41...

I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level: Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging elifesciences.org/articles/96892

dohanews.co/qatar-invest... This could be interesting…

Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer. But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.

(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS

Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Come and work with us!! 🤩

This makes no sense to me. How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health? www.nature.com/articles/s42...

#chatgpt #llms

This is great news: UK Biobank Proteomics Project Receives £20M From UK Government for Olink HT characterization of 300k samples www.genomeweb.com/research-fun...

Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social

#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT www.verwaltung.uni-halle.de/dezern3/Auss... #Academicsky #Chemsky #teammassspec

Having worked with #Seer before, this sounds pretty interesting ... www.globenewswire.com/news-release...

please find below our latest paper on #AD www.nature.com/articles/s41... Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

I'm pretty sure this must be due to a underlying large-effect methylation QTL.

Did you know that DNA methylation can show Mendelian inheritance pattern? clinicalepigeneticsjournal.biomedcentral.com/articles/10....

The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene". But only slightly less well-known is this: consider the colocalized phenotypes. That is, a genetic variant seldom disrupts exactly one phenotype. What else does tugging on that thread do?

I guess I should take advantage of our pig experiment getting delayed to read these 😅

Amazing paper ... they translated everything from our earlier #metabolomics GWAS from humans to pigs: @biocrates platform journals.plos.org/plosgenetics... pathways from GGM bmcsystbiol.biomedcentral.com/articles/10.... hypotheses-free ratios bmcbioinformatics.biomedcentral.com/articles/10....

Interested in joint multiomics data? Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq) Check out our COMICS server littleswissriver.shinyapps.io/generate_net... and BLOG www.metabolomix.com/comics/

When one of your first research papers from 30 years back just got cited, and the figures look very similar, you ask yourself where time went - did the research questions change? Our 1994 paper: link.springer.com/article/10.1... Recent 2022 paper: agupubs.onlinelibrary.wiley.com/doi/10.1029/...

You want to see an octopus riding a shark. 🎥: University of Auckland www.nytimes.com/2025/03/20/s...

This new paper @nature.com today on the genesis and evolution of stomach cancer goes against the alt-model nature.com/articles/s41... nature.com/articles/d41...

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes www.nature.com/articles/s41...