Pharma companies take note - human knockouts in bottleneck and consanguineous populations are up and coming. Plasma Metabolic Outliers Identified in #Estonian Human Knockouts: www.mdpi.com/2218-1989/15... citing our #Qatar study with @metabolon.bsky.social data: www.cell.com/cell-genomic...

“Our study [in Cancer Discovery] suggests a new therapeutic approach to block metastasis before it starts, and help patients overcome triple negative breast cancer,” said Dr. Vivek Mittal (@MittalLab) from the Meyer Cancer Center and there EIPM. news.weill.cornell.edu/news/2025/10...

🔬Inside the Core Lab: Driving Discovery in #Proteomics Explore one of the key labs supporting cutting-edge proteomics research in Qatar. Meet the team and discover the advanced technologies driving biomedical breakthroughs. Featured in the lead-up to #QPC2025 — where innovation meets collaboration.

This Report outlines research Recommendations from the NIDDK’s Working Group of Council on Heterogeneity of #Diabetes, a result of tremendous effort and significant contributions from global investigators and #NIDDK staff. www.niddk.nih.gov/about-niddk/...

A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...

October's #LipidoftheMonth is a sterol that might be causing quite a buzz soon. www.lipidmaps.org/updates/lipi...

"A standardized framework for circulating blood proteomics" ... it summarizes many of the challenges encountered in the field, although I miss any reference to genetic aspects of blood proteomics, i.e. cis-pQTLs to confirm target specificity and epitope effects www.nature.com/articles/s41...

I have always been a proponent of hypothesis-free testing of metabolite rations: This paper is just great in how it takes it to the next level: Untargeted pixel-by- pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging elifesciences.org/articles/96892

dohanews.co/qatar-invest... This could be interesting…

Years ago I asked on Twitter why my heart rate would continue to climb even after I fixed the speed and incline on my treadmill. At the time, no one on Twitter could give me a satisfactory answer. But now GPT4o was able to answer it and suggested approaches to quantify the phenomenon.

(J Proteom Res) [ASAP] Understanding Data Analysis Steps in Mass-Spectrometry-Based Proteomics Is Key to Transparent Reporting: Journal of Proteome ResearchDOI: 10.1021/acs.jproteome.5c00287 #MassSpecRSS

Prefusion gB of HSV bound with a neutralizing nanobody www.nature.com/articles/s41...

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Come and work with us!! 🤩

This makes no sense to me. How does genetically predicted walking speed relate to biological aging (here as telomere length( except as some sort of biomarker of overall health? www.nature.com/articles/s42...

#chatgpt #llms

This is great news: UK Biobank Proteomics Project Receives £20M From UK Government for Olink HT characterization of 300k samples www.genomeweb.com/research-fun...

Fantastic start to the day here at the 3rd "Human Proteome and Health" Symposium at Rhodes House where Dr Katerina Gospodinova from the ARUK-ODDI and @cmd.ox.ac.uk discussed proteomic profiling of the #matrisome for use a novel therapeutic modality in #Alzheimers Disease 🧠 @arukthamesv.bsky.social

#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...

‼️ Job alert 🚨: I have an open 3-year postdoc position in my lab to develop novel crosslinking mass spectrometry workflows. 🧪🧪 So if you want to do cool stuff in protein MS, please apply ! ⬇️ Please RT www.verwaltung.uni-halle.de/dezern3/Auss... #Academicsky #Chemsky #teammassspec

Having worked with #Seer before, this sounds pretty interesting ... www.globenewswire.com/news-release...

please find below our latest paper on #AD www.nature.com/articles/s41... Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease

I'm pretty sure this must be due to a underlying large-effect methylation QTL.

Did you know that DNA methylation can show Mendelian inheritance pattern? clinicalepigeneticsjournal.biomedcentral.com/articles/10....

The most famous heuristic in mapping gwas snps to genes is "it's usually the closest gene". But only slightly less well-known is this: consider the colocalized phenotypes. That is, a genetic variant seldom disrupts exactly one phenotype. What else does tugging on that thread do?

I guess I should take advantage of our pig experiment getting delayed to read these 😅

Amazing paper ... they translated everything from our earlier #metabolomics GWAS from humans to pigs: @biocrates platform journals.plos.org/plosgenetics... pathways from GGM bmcsystbiol.biomedcentral.com/articles/10.... hypotheses-free ratios bmcbioinformatics.biomedcentral.com/articles/10....

Interested in joint multiomics data? Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq) Check out our COMICS server littleswissriver.shinyapps.io/generate_net... and BLOG www.metabolomix.com/comics/

When one of your first research papers from 30 years back just got cited, and the figures look very similar, you ask yourself where time went - did the research questions change? Our 1994 paper: link.springer.com/article/10.1... Recent 2022 paper: agupubs.onlinelibrary.wiley.com/doi/10.1029/...

You want to see an octopus riding a shark. 🎥: University of Auckland www.nytimes.com/2025/03/20/s...

This new paper @nature.com today on the genesis and evolution of stomach cancer goes against the alt-model nature.com/articles/s41... nature.com/articles/d41...

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes www.nature.com/articles/s41...

Genome-wide Association Studies of Missing Metabolite Measures: Results From Two Population-based Studies www.medrxiv.org/content/10.1... I wonder what a GWAS with imputing missing to zero would yield in comparison.

Oh, wow, this is a massiv dataset

Interested in joint multiomics data? Metabolon, Biocrates, Lipidyzer, Chenomx, SOMAscan, Olink, Nightingale, Genos, Exiqon and Illumina genomics (OmniArray, HumanMethylation, RNAseq) Check out our COMICS server littleswissriver.shinyapps.io/generate_net... and BLOG www.metabolomix.com/comics/

A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes www.nature.com/articles/s41...

A study associating 5,000 plasma proteins (SOMAscan) with BMI and waist-hip ratio: Plasma Proteomic Signatures of Adiposity Are Associated With Cardiovascular Risk Factors and Type 2 Diabetes Risk in a Multiethnic Asian Population diabetesjournals.org/diabetes/art...

💯 RFK Jr. approved!

A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink: Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults www.nature.com/articles/s41...

Here a GWAS with MS-proteomics in 700 GTEx samples reporting 1981 cis-pQTLs Regulation of protein abundance in normal human tissues www.medrxiv.org/content/10.1... Interesting link between NAT2 and HMGCR - the locus also associates with statin use in FinnGen (p=2.5e-15)

A paper addressing discrepancies between Olink and SOMAscan. Most important factor explaining the (non)correlation is the % of LOD samples in Olink: Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults www.nature.com/articles/s41...

Here a 3D fullerene C60 molecule that I 3D printed starting with a PDB structure file. Here is how to do it: makerworld.com/en/models/96...

Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers: The HuMet Repository - Watching human metabolism at work www.sciencedirect.com/science/arti... All data provided in an interactive repository: humet.org

Here a 3D fullerene C60 molecule that I 3D printed starting with a PDB structure file. Here is how to do it: makerworld.com/en/models/96...

Free access to 2,656 metabolites from 9 platforms measured at 56 time points and covering 6 challenges "suffered" by 15 healthy volunteers: The HuMet Repository - Watching human metabolism at work www.sciencedirect.com/science/arti... All data provided in an interactive repository: humet.org

Amazing what 3D printing can achieve these days.

I just updated the Table of all published #GWAS with #Metabolomics with the latest GWAS in urine with Nightingale NMR ... if you know of other recent GWAS that I am missing, pease let me know. www.metabolomix.com/list-of-all-...

Large-scale proteomic analyses of incident Parkinson’s disease reveal new pathophysiological insights and potential biomarkers ... an analysis based on the 50k #Olink #proteomics data from @ukbiobank.bsky.social www.nature.com/articles/s43...

Identification of novel proteomic biomarkers for hypertension: a targeted approach for precision medicine. ... using @somalogic.bsky.social data measured by the @weillcornell.bsky.social - Qatar #proteomics core for the #Qatar #Biobank. clinicalproteomicsjournal.biomedcentral.com/articles/10....