Advanced imaging of ovarian tumor samples shows that PARP inhibitors can become trapped in lysosomes, creating internal drug reservoirs that may influence treatment resistance and effectiveness. doi.org/hbswwr

Why do some #cancer cells develop treatment #resistance? The answer may lie in hidden “storage hubs” inside #tumour cells, which create uneven drug exposure across tumours, according to new #research led by @louisefets.bsky.social from 🇬🇧 @mrc-lms.bsky.social.

Great collaboration that took us to places we definitely were not anticipating! Thank you Zoe and congratulations to you too! 🎉 ♥️

Join us in Belfast for two days of rigorous metabolic science, ECR-led talks and posters, and exciting opportunities for collaboration. The UK Cancer Metabolism Network is a young but fun and open community - do check out the meeting, registration open until 24th March!

📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below

Congratulations Will Scott and team @mrc-lms.bsky.social on some fantastic work looking at how adipose tissue remodels in obesity and weight loss.

Seconded! Worth a look for anyone who wants to open a lab working on metabolic physiology and/or disease, or immunometabolism

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Congrats to the drug transport and tumour metabolism group, headed by @louisefets.bsky.social for winning two awards!

#JobAlert! We have an opening for a postdoctoral scientist in #CancerMetabolism in my lab @mrc-lms.bsky.social. If you're interested in the role of metabolism in drug response and resistance in cancer, and would like to work in a fun and friendly team, check it out: lms.mrc.ac.uk/work/vacanci...

We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS

Eeekkk HUGE congratulations @aakritijain.bsky.social and @robzonculab.bsky.social! 🎉 🎉 🎉 Such a cool story and very pleased to see it out!

🚨 Less than one week until the abstract deadline for the Mechanisms of Membrane Transport GRS!! 🚨 📅 Apply by Feb 16th! If you enjoy learning about novel insights into membrane transporters in beautiful places, this is the conference for you! 🧪 #STEMseminar

Fantastic time at the lab's first retreat with @Alexis_Barr lab - great to get away and have some time for team building and big picture thinking. Very proud of how open and engaged both teams were. Until next time!

Really excited to be invited to this GRS event, these small group conferences are always a lot of fun and so great for learning and networking. Well worth a look for any ECRs in the membrane transport field!

Exciting data on the pro-survival role of p21 in NSCLC! Congratulations Steve and @alexisbarr.bsky.social, and I hope this will be the first of many collaborative papers together! 🥰

Huge congratulations @ginevradoglioni.bsky.social and @fendtlab.bsky.social! 🌟 Excited to read!

Excited to announce two DFG-funded PhD positions to study Lipid Droplet Heterogeneity in cancer as part of FOR5815. Join us @dkfz-heidelberg if you are interested in #cancermetabolism and #lipidbiology jobs.dkfz.de/en/jobs/1673... jobs.dkfz.de/de/jobs/1673...

A PhD position in computational genomics is open in our group at Imperial/MRC LMS! 🌟 Join the DANIO-ReCODE Doctoral Network and work on gene regulation, evolution, development, and tissue regeneration. Open to all (except those residing in the UK in the past year). Deadline: 8 Jan 2025. t.ly/fDdDW

New PI positions @mrc-lms.bsky.social 👀 It's truly a great place to start a lab, definitely worth a look if you're on the job market. Please share with your networks!

We are hiring! Programme Leader Track positions @mrc-lms.bsky.social up for grabs by up-and-coming researchers with a great start to their career who now aim to establish their own group in a translational discovery science institute of world leading excellence. lms.mrc.ac.uk/work/vacanci...

It's been a good year for the lab, with highs including a new PhD, paper submitted and an AACR grant won. Some bitter sweet moments saying goodbye to some lovely lab members, but welcoming some great new/returning ones too. Merry Christmas to you all from all of us ♥️🎄🥂 🌟

Medical research has transformed the treatment of #ovariancancer recently but resistance to the new class of drugs - parp inhibitors - must be overcome in order to realise their full potential. Congratulations Dr @louisefets.bsky.social & Dr Moncayo - the patient community is cheering you on!

Really excited and grateful to receive this funding from @theaacr.bsky.social, which will allow Carmen and I to continue working on the molecular basis and consequences of heterogeneous #PARPinhibitor distribution in #ovariancancer ...first paper on this hopefully coming soon - watch this space!

Wow, predatory journals now asking for WhatsApp numbers?? Has anyone else had this? A whole new level of creepy

We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too! 👉 www.godinholab.com RT please 🙏🙏🙏👍👍

The deadline for abstract submissions and discounted early bird tickets for our upcoming #INTERPHACE2025 symposium is this Friday 13 December 📅 The symposium aims to foster collaboration between experimental and theoretical/computational life sciences. www.crick.ac.uk/whats-on/int...

Save the date!! the BACR 65th Anniversary Meeting will be held in Edinburgh next June (2nd-4th) and has a broad focus so there is something for everyone in the cancer field. Registration opens January. Please help spread the word!

Hear about our research @mrc-lms.bsky.social on digital heart health from BBC World Service (near the start) www.bbc.co.uk/programmes/p...

Fantastic day celebrating the science of @mrc-lms.bsky.social held at the beautiful Royal Institution. Thank you for all the inspiring talks, proud to be part of this great community!

🚨 Please share 🔔 2x fully funded #Postdoc positions available If you are interested in - #epigenetic memory of stem and #cancer cells. - functional analyses of #microbes in cancer please get in touch. We have two cracking projects with collaborators in the EMBL Partnership.

Exciting news in cancer therapy! The order of drugs impacts the duration of treatment, toxicity, and economic cost. A necessary example of how relevant academic, self-funded trials are!! Breast #cancer #oncosky #oncsky #medsky 🧪 @natureportfolio.bsky.social www.nature.com/articles/d41...

I have curated a second "metabolism" starter pack, as the first quickly got full. Please have a look, and I am happy to add others (sorry for those who may appear in both): go.bsky.app/CH1MctZ

Happy to share our first #bluetorial & our latest #preprint, lead by postdoc @paulchammas.bsky.social. We used CRISPRa to disentangle the close relationship between Dux and MERVL elements in the induction of the 2-cell like state: #TEsky #MERVL www.biorxiv.org/content/10.1... (1/8)