Ancestral Genomes xkcd.com/3252/

I’m looking to hire one or two postdocs - possible projects include pop gen theory, methods development, and human evolutionary inference. Please share, and email if you are interested. More info: evoldir.net/brian/evoldi...

Summary of Key Changes in OMB’s Proposed Federal Financial Assistance Rule. Russell Vought is going destroy American Science. elizabethginexi.substack.com/p/summary-of...

Bastian, Enard & Lartillot tested predictions of the nearly-neutral theory of molecular evolution across time scales, confirming the role of effective population size in tuning selection efficacy in placental mammals. 🖌️ Léa Backory 🔗 doi.org/10.1093/gbe/evag030 #genome #evolution

New preprint! We sequenced 175 'Alalā (Hawaiian crow) genomes to understand why >50% of eggs fail to hatch in a species recovered from just 9 individuals. What we found was a both exciting and surprising. www.biorxiv.org/content/10.6...

44% funded in just 12 hours! Order Tom Chitty's wonderful cartoon book, Nooks and Crannies of New York -- it's like nothing you've ever seen. www.kickstarter.com/projects/mic...

@hggadvances.bsky.social sat with Steven Gazal, PhD, in the latest "Inside HGG Advances" to discuss his recently published paper, “Evaluating genetic ancestry inference from single-cell transcriptomic datasets.”➡️ https://bit.ly/4b3MQgn #ASHG #GeneticsDiscoveries

📢 Postdoc position available in my lab We study mutagenesis, population genetics, and Mendelian genomics—linking the origins of mutations to their biological and disease consequences. Details about research directions: labs.utsouthwestern.edu/seplyarskiy-... Please reach out if interested.

I just submitted my letter to NSF responding to its proposal to dismantle the National Center for Atmospheric Research (NCAR). I argue that doing so would be an astonishing and avoidable misstep, and that federal support for the institution should in fact be *increased.* [1/4]

Have you ever wondered how many archaic populations contributed DNA to modern humans? We know about Neanderthals and Denisovans, but the fossil and genetic evidence suggests a much more complex history! www.biorxiv.org/content/10.6...

Wheeee! The @americanbystander.bsky.social has posted another Five Pages of Fun for all! #magazine #humor #comics #publishing Best damn humor mag in the US! online.americanbystander.org/five-pages-o...

Excited to share our new preprint! 🍇🧬 We analyzed 639 genomes across 48 grape species to understand how hybridization drives adaptation. • ~14% of average Vitis genome is introgressed • Most parallel adaptations are shared via gene flow • Two "hybrid species" are actually hybrid swarms

For folks that have tried both codex (5.3-codex) and claude, what are your thoughts? I've been using codex with some success, but it seems very limited compared to the subagent and plugin capability that claude has.

Can confirm

In a new GBE Review, @david-peede.bsky.social et al. overview the SMC model and extensions, discuss examples of discoveries made with the help of SMC-based inference, and comment on the assumptions, benefits, and drawbacks of various methods. 🔗 doi.org/10.1093/gbe/... #genome #evolution #compbio

Happy to share our new preprint from @sashagusevposts.bsky.social and @nmancuso.bsky.social labs! We introduce Mr. PEG, a framework integrating perturbational screens, eQTL, and GWAS data to identify mediating genes for complex traits. (1/n) www.medrxiv.org/content/10.6...

How much better is an ancestral recombination graph (ARG) than a site frequency spectrum (SFS)? For recovering mutation rate history, we can answer fairly precisely because both ARG and SFS are linear transforms of mutation rate history. This blog post uses spectral analysis to clarify the picture.

🧬 Just out in Bioinformatics Advances: “tskit arg visualizer: Interactive plotting of ancestral recombination graphs.”  Read the full paper here: https://doi.org/10.1093/bioadv/vbaf302 Authors include: @kitchensjn.bsky.social, @yanwong.bsky.social

Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...

Amazing to have a byline with @cbo.bsky.social - read our take on Watson’s ultimate legacy in the Boston Globe. Will be in Sunday’s print edition.

We're excited to share the final version of our paper, where we demonstrate how confounding remains a thorny problem for claims about causal genetic influences on human behavioral and socioeconomic outcomes. (w/ @jedidiahcarlson.com @oliviarxiv.bsky.social Ruth Shaw @arbelharpak.bsky.social) 🧵👇

JOB POSTING: Director, National Human Genome Research Institute hr.nih.gov/careers/open...

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

If you are at #ASHG2025 and would like to chat in person, please reach out! My lab is looking for curious scientists to join us, especially (but not limited to) postdoctoral researchers.

Thread: A year ago yesterday was a very happy day for me. I had lost my prostate. It was good riddance, as it was riddled with cancer. I’m now cancer-free — and thankful for the tax-funded technology that saved my life.

The MBE Best Student Paper award of 2024 goes to Julien Joseph (winner) and William S. Henriques (runner-up). 👏 Congratulations Julien and William for this recognition of your amazing work! Check below for details on their research ⬇️

PEQG website live! genetics-gsa.org/peqg-2026/

Science is intertwined with eugenics, and eugenic ideologies continue to negatively impact #Indigenous communities and science today. Read a timely and important perspective piece in #GENETICS from @jazlynmooney.bsky.social and colleagues: buff.ly/T7rbV3k

Exciting updates!! (1) I just opened my lab at Boston Children’s Hospital (Harvard-affiliated) (2) I’m hiring a postdoc focused on integrating GWAS and functional genomic data. Reach out if you’re interested or connect at ASHG next week! (3) Learn more at stroberlab.com

Population Biology Modeling & Theory (PBMT) is a peer-reviewed journal reporting advances in modeling and theory within population biology. Its scope spans demography, ecology, epidemiology, evolutionary biology, population genetics, and phylogenetics. PBMT will be online soon.

Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE academic.oup.com/mbe/article/... (1/n)

Would be excited to chat with folks looking for a postdoc in AI to develop models for genomic prediction... A great opportunity for funding coming up soon is the Schmidt AI in Science fellowship, due October 13th! apply.interfolio.com/173322

In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!

📣Online now from @arundurvasula.bsky.social & co! 📄Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers 👉https://bit.ly/47HmkYW

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process! www.cell.com/hgg-advances... cc @kewesterman.bsky.social

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

We regret to inform you we have returned to social media. Sorry.

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process! www.cell.com/hgg-advances... cc @kewesterman.bsky.social

First author @xilinjiang.bsky.social is now on Bluesky!

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1... Very cool results: Accumulating E with age reduces heritability & PGS effects Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Call for Papers! 🧵 The Public's Science–A New Social Contract for American Research Policy a Special Issue of The ANNALS of the American Academy of Political and Social Science Editors: Alondra Nelson (IAS) and Jenny Reardon (UC, Santa Cruz) Abstract Deadline: Sept 19 www.ias.edu/stsv-lab/pub...

Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime. telliamedrevisited.wordpress.com/2025/08/12/s... STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.

Our paper showing that variation in transcription factor binding sites underlies the majority of additive genetic variance for phenotypic variation in maize is finally out! Sadly they didn't use our suggested cover image below (made by the inimitable Andi Kur). www.nature.com/articles/s41...

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

Arun Durvasula, PhD, of @uscpphs.bsky.social writes, "Lifestyle factors play a large role in determining who gets a disease and who doesn’t. But they are far from the entire story." A fascinating read about the relationship between genetics and our environment. ⬇️ 🔗 #Science #MedSky #ResearchSky

The evolution of sex-specific gene expression in polygenic traits @ewanflintham.bsky.social doi.org/10.1093/jeb/...

Multiple-testing corrections in case-control studies using identity-by-descent segments https://www.biorxiv.org/content/10.1101/2025.07.03.663057v1