Would be excited to chat with folks looking for a postdoc in AI to develop models for genomic prediction... A great opportunity for funding coming up soon is the Schmidt AI in Science fellowship, due October 13th! apply.interfolio.com/173322

In the midst of the darkness, I am pleased to announce that UCLA will be hosting the upcoming Southern California Evolutionary Genetics (SCalE) conference on November 1! Registration & abstract submission is here: www.scalemeeting.org/home Deadline is October 13! Hope to see you at UCLA!

📣Online now from @arundurvasula.bsky.social & co! 📄Pathway-specific polygenic scores substantially increase the discovery of gene-adiposity interactions impacting liver biomarkers 👉https://bit.ly/47HmkYW

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process! www.cell.com/hgg-advances... cc @kewesterman.bsky.social

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

We regret to inform you we have returned to social media. Sorry.

Our work on leveraging pathway-specific polygenic scores to discover gene-environment interactions is now online at HGG Advances (@hggadvances.bsky.social). 10/10 great review process! www.cell.com/hgg-advances... cc @kewesterman.bsky.social

First author @xilinjiang.bsky.social is now on Bluesky!

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

📣Just out: Exposure accumulation drives age-dependent disease architectures and polygenic risk scores www.medrxiv.org/content/10.1... Very cool results: Accumulating E with age reduces heritability & PGS effects Led by Xilin Jiang (Wellcome ECR joint w/Alkes Price) + @arundurvasula.bsky.social

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Call for Papers! 🧵 The Public's Science–A New Social Contract for American Research Policy a Special Issue of The ANNALS of the American Academy of Political and Social Science Editors: Alondra Nelson (IAS) and Jenny Reardon (UC, Santa Cruz) Abstract Deadline: Sept 19 www.ias.edu/stsv-lab/pub...

Excited to share new #program, STEPS, which can simulate #dynamics of the E. coli Long-Term Evolution Experiment (#LTEE) or other microbes in serial transfer regime. telliamedrevisited.wordpress.com/2025/08/12/s... STEPS developed by @devinmlake.bsky.social, Zachary Matson, Minako Izutsu, and me.

Our paper showing that variation in transcription factor binding sites underlies the majority of additive genetic variance for phenotypic variation in maize is finally out! Sadly they didn't use our suggested cover image below (made by the inimitable Andi Kur). www.nature.com/articles/s41...

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

Arun Durvasula, PhD, of @uscpphs.bsky.social writes, "Lifestyle factors play a large role in determining who gets a disease and who doesn’t. But they are far from the entire story." A fascinating read about the relationship between genetics and our environment. ⬇️ 🔗 #Science #MedSky #ResearchSky

The evolution of sex-specific gene expression in polygenic traits @ewanflintham.bsky.social doi.org/10.1093/jeb/...

Multiple-testing corrections in case-control studies using identity-by-descent segments https://www.biorxiv.org/content/10.1101/2025.07.03.663057v1

Some nice press coverage of our efforts to assemble the genome of the critically endangered palila with Hawaiian high school students and teachers: www.hawaiinewsnow.com/2025/07/01/t...

Check out our new review about addressing missing context in regulatory variation across primate evolution 🧬🐒 www.sciencedirect.com/science/arti...

Happy to see this out! @reginafairbanks.bsky.social analysis of perhaps the most famous maize domestication locus, teosinte glume architecture 1, which controls much of the change from the enclosed fruitcase (top) in teosinte to the "naked" grains of maize (bottom) www.pnas.org/doi/10.1073/... 1/2

Very happy to have been part of this project. Go check this dive on SMC-based models!

Our review of recent Sequentially Markovian Coalescent methods is up on arXiv: arxiv.org/abs/2506.00692 (based on last year's @official-smbe.bsky.social symposium)

Are you an early-career researcher working on the computational analysis of population-level human genetics data? We want to hear from you about if, how, and why you use population descriptors in your research! Fill out our short survey: forms.gle/SCiNUq71wgi5...

I'm excited to share I'll be starting a faculty position at Boston Children's Hospital in the Computational Health Informatics Program (CHIP) this October!!

Out today in @pnas.org! www.pnas.org/doi/10.1073/...

Very excited to share the first paper from my postdoc at the San Diego Zoo Wildlife Alliance on the population genomics of recovery and extinction Hawaiian honeycreepers: Paper: doi.org/10.1016/j.cu... Press release: sandiegozoowildlifealliance.org/PR/hawaiian-... ‪@currentbiology.bsky.social‬

Hello, Our paper on enamel proteins from Paranthropus robustus has finally been peer reviewed, please have a read here: www.science.org/doi/10.1126/... Paranthropus robustus has been puzzling scientists since its discovery in 1938 in South Africa, where a high number of fossils have been found.

Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...

Check out my new article published in @aeon.co on the continued relevance of JBS Haldane's 1964 "A Defense of Beanbag Genetics". (Love that they chose the peppered moth as the cover for it!) aeon.co/essays/a-res...

How your genes interact with your environment changes your disease risk − new research counts the ways buff.ly/A6aBV3H

Super excited to share my latest preprint with @klohmueller.bsky.social! Here we leverage the unique signature that recessive deleterious variants can lead to an increase in archaic ancestry to tackle a classic question - the dominance distribution on the human genome www.biorxiv.org/content/10.1...

Excited to see the final version of this paper with @samurscicop.bsky.social and Daniel Matute out in @genomebiolevol.bsky.social! We took a dive into the complicated demographic history of Aedes aegypti mosquitoes and its impact on the distribution of genetic diversity doi.org/10.1093/gbe/...

Aneuploidy is the leading cause of pregnancy loss. In work led by @saracarioscia.bsky.social and @aabiddanda.bsky.social, we reanalyzed genetic testing data from 139,416 IVF embryos to discover variants associated with recombination phenotypes and aneuploidy risk. www.medrxiv.org/content/10.1...

Excited to share: "Addressing missing context in regulatory variation across primate evolution" arxiv.org/abs/2504.02081

Excited to share: "Addressing missing context in regulatory variation across primate evolution" arxiv.org/abs/2504.02081

I dug deep and pulled Human Longevity's PRS for facial prediction and applied this is what it generated?

@ajhgnews.bsky.social latest article quantifies and distinguishes three different types of gene-environment (GxE) interactions, and reveals a significant contribution of GxE to complex trait variance: www.cell.com/ajhg/abstrac... #ASHG #HumanGenetics @arundurvasula.bsky.social

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

Excited to share a couple of new items (links below): 1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics 2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution

I wrote up an FAQ about the recent federal grant cuts. A few points: 🧵

📣Online now! 📄Distinct explanations underlie gene-environment interactions in the @ukbiobank.bsky.social 🧑‍🤝‍🧑 @arundurvasula.bsky.social & Price

One more day for abstract submission! Join us at Hinxton for the 2025 Human Evolution conference bit.ly/4ajmLI6

Excited to share a couple of new items (links below): 1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics 2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution

ASHG is concerned about the cuts to NIH-funded research support, its impacts on biomedical research, and the effect on local, state, and national economies. We join our advocacy partners to ensure essential progress is not stalled. Read our statement: www.ashg.org/publications... #ASHG

A few years ago, I gave a lecture about how the Soviet Union denied genetics for years as "bourgeois perversion." There are lessons to be learned about what can happen to science. carlzimmer.com/lets-not-los...

@ajhgnews.bsky.social sat with Jessica Honorato-Mauer, MS, in the latest "Inside AJHG" to discuss her recently published paper, “Characterizing features affecting local ancestry inference performance in admixed populations.”➡️ www.ashg.org/ajhg/inside-... #ASHG #GeneticsDiscoveries #HumanGenetics

The 2nd conference of the Society for Mathematical and Theoretical Population Biology @smtpb.bsky.social will be in Chicago @nitmb.bsky.social June 2-6. Applications are now open, both to attend (junior applicants can apply for financial support), and to present, at www.nitmb.org/modeling-and...

Spent an hour today, training 15 of the next generation of Genetics & G3 peer reviewers recruited via the @genetics-gsa.bsky.social’s training program. The future is bright y’all! If you’re an early career researcher looking for peer review experience, watch for the next cohort call - link below.