Very excited about this year’s Biology of Genomes meeting, especially keynotes from @jkpritch.bsky.social and @janetk.bsky.social. A great venue to see what’s new and upcoming in genomics, writ broadly. Abstract submissions due in 1 week!

Happy to share my work with my advisor Zachary Szpiech! Why are associations between ROH & complex traits inconsistent across studies? We use realistic simulations to show how demographic history and genetic architecture interact to shape the phenotypic impact of ROH. www.biorxiv.org/content/10.6...

The registration deadline is fast approaching for probgen 2026! Abstracts due by January 15, registration by January 31 probgen2026.github.io

Grateful to share our paper on gene-specific selective sweeps in human gut microbiomes, now out in Nature! It has been a joy to work with @rwolff.bsky.social, whose insights and hard work made this possible. www.nature.com/articles/s41...

Well well. The standard model for how frequencies of recessive disease genes are established doesn't work. And that seems to be because recessive variants are visible to selection due to pleiotropy. (But still we teach Mendelian genetics...) www.biorxiv.org/content/10.6...

Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...

Work from my amazing undergrad @leyan-wang.bsky.social is just preprinted! TL;DR: If you worry that ARG methods might fail on unphased data due to phasing errors, you may not need to. Check it out & consider reposting to support a great young scientist!

And another paper from the admixlab: SAI - statistics for adaptive introgression! doi.org/10.1093/molb...

I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...

I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!

Sophie Buysse's paper on short stamen loss in Arabipsis is published in this month's Evolution issue!! academic.oup.com/evolut/artic... @journal-evo.bsky.social

Having major FOMO about #SMBE2025 in my hometown… but I’m very proud that my postdoc, Susanna Gutierrez, will be presenting our work on inferring the selection history of adaptive introgression candidates in Peruvians at poster S12-P19. Please visit her during poster session 3 if you're interested!

The preliminary program of ProbGen 2026, which will be held at UC Berkeley, is now up: probgen2026.github.io Sharing on behalf of Rasmus Nielsen who is not on this site. For more see his thread on that other site: x.com/ras_nielsen/...

Super excited to share my latest preprint with @klohmueller.bsky.social! Here we leverage the unique signature that recessive deleterious variants can lead to an increase in archaic ancestry to tackle a classic question - the dominance distribution on the human genome www.biorxiv.org/content/10.1...

Repost w/ correct link! The Dept of Human Genetics at the Univeristy of Utah is hosting a Rising Stars in Genetics & Genomics postdoc symposium. We are looking to feature postdocs doing cool science! Please self nominate or nominate an excellent postdoc! #ASHGtrainees docs.google.com/forms/d/e/1F...

Kirk Lohmueller DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬 #HumanEvo25

a quick note on my paper with @jeffspence.bsky.social and @jkpritch.bsky.social on conditional frequency spectra, now out in a @genetics-gsa.bsky.social special issue: doi.org/10.1093/genetics/iyae210

Excited to share: "Addressing missing context in regulatory variation across primate evolution" arxiv.org/abs/2504.02081

A really nice paper by @drghawkes.bsky.social et al. argues that rare and common genetic associations converge on the same genes. While this seems at odds with our recent work about how burden tests and GWAS prioritize different genes, our results agree (🧬🧪🧵 1/6) www.biorxiv.org/content/10.1...

Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry www.science.org/doi/10.1126/...

Grundler et al propose a new method to infer the geographic position of all our genetic ancestors www.science.org/doi/10.1126/... building on a method by Wohns et al www.science.org/doi/10.1126/.... My thoughts on the approach: www.science.org/doi/epdf/10.....

Think of a polygenic score you care about. Are direct genetic effects driving variation among people in this predictor? Or perhaps other, confounding factors? We at the @arbelharpak.bsky.social & @docedge.bsky.social Labs developed a method to tackle this question. [1/n]

We are thrilled to share that our paper entitled "Inference of the demographic histories and selective effects of human gut commensal microbiota over the course of human history" is officially out in MBE! academic.oup.com/mbe/advance-...

Thrilled to have been a part of this study led by @aidaandres.bsky.social that finds evidence of genetic adaptation in chimpanzees to different habitats. Most notably signatures of positive selection in chimpanzees underlie resistance to malaria in humans (GYPA and HBB).