Headed to #PEQG26 next week? The Sethuraman Lab will be presenting a buncha recent work! Come find us at both poster sessions, and DM/message me if you'd like to chat about the open postdoc position in my lab.

Our preprint on the genetic regulation of mtDNA gene expression in collaboration with @shwetaramdas.bsky.social and @rajivmccoy.bsky.social .

postdoc alert 🚨! NIH-funded postdoc in my lab to work on Ancestral Recombination Graphs in space. Please spread the word widely in your networks, and please reach out if you're interested! (2-3yr position, start date flexible, pay/benefits good!). details here: careers.umich.edu/job_detail/2...

Abstract deadline for Midwest Pop Gen 2026 extended to June 12th! Aug 21-22 at UChicago — free, trainee-oriented meeting with talks, posters + Friday BBQ at Promontory Point. Chicago in August doesn't get better than this... jkreinz.github.io/mwpg2026

Happy to present our perspective on how to think about group-differences in genetic risk. With @nicole-kleman.bsky.social , Meng Lin, and Chris Gignoux.

I try not to complain about things but biorxiv refused to preprint our perspective piece and arxiv wants an endorsement from two unicorns who have preprinted there in the last 5 yrs in the same subsection before we can post anything. Preprinting shouldn’t be this hard.

📣 𝐖𝐞’𝐫𝐞 𝐡𝐢𝐫𝐢𝐧𝐠 𝐚 𝐩𝐨𝐬𝐭𝐝𝐨𝐜 𝐢𝐧 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 & 𝐬𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬! 🌍📈🧬 If you’re finishing a PhD (or know someone who is) and want to work on complex trait biology + 𝑟𝑒𝑎𝑙-𝑤𝑜𝑟𝑙𝑑 𝑖𝑚𝑝𝑎𝑐𝑡, read on 👇

Please share! The USC Department of Quantitative and Computational Biology is searching for a full-time, teaching-track faculty member for the teaching of QBIO undergraduate statistics and computational biology courses. usccareers.usc.edu/job/los-ange...

Eid Mubarak friends!

Friends and Colleagues! I am SO excited to catch up with you all this week at #AABA2026! Here is a quick 🧵summarizing what our 🧪🧬👩🏽‍💻👨🏿‍🔬👩🏼‍🔬🧑‍💻lab will be presenting at the meetings (1/n) @umncla.bsky.social @umnanth.bsky.social www.nievescolonlab.org

Glad to be part of a community that values the well-being and safety of its neighbors.

We visited Renee Good's memorial. There, we met a group of Somali Minnesotans — who too have been viciously attacked for weeks — warmly hosting everyone. Flowers & stuffed animals galore. Neighbors continually offering sambusas & hand-warmers & water. Grief. And belief. Scenes from Minneapolis:

I'm just delighted to announce our new preprint on genome-scale perturb-seq in CD4+ T cells. We learned both general lessons about the power of perturb-seq, and specific lessons about T cell biology. Led by amazing postdocs Emma Dann and Ronghui Zhu, with my wonderful collaborator Alex Marson.

My second dissertation paper is now out in @natcomms.nature.com! Here we introduce the co-expression-wide association study (COWAS) method for identifying pairs of genes or proteins whose genetically regulated co-expression is associated with complex traits. 🧵⬇️ www.nature.com/articles/s41...

Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...

As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)

Our first labsgiving/Diwali celebration 🪔!

Hey Yaniv Brandvain is not on Bluesky but his most recent biostats ebook is live ybrandvain.github.io/biostats/. His stats resources have been so helpful to me as I develop my own stats course, so check it out. Github repo here: github.com/ybrandvain/b...

reminder that my (wonderful, diverse, interdisciplinary) department at the University of Oregon is seeking applications for an Associate/Full Professor of Data Science -- deadline 10/31 and only cover letter/CV needed to apply academicjobsonline.org/ajo/jobs/30328

I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

If you are at #ASHG2025 and would like to chat in person, please reach out! My lab is looking for curious scientists to join us, especially (but not limited to) postdoctoral researchers.

We will be at #ASHG25 this year! Some presentations from our group, please stop by! :

🔔 Excited to share our preprint from the largest ever exome-wide association study for T2D in South Asians. We make important discoveries implicating the genes HNF4A, GP2, RNF19A in the aetiology of diabetes and metabolic traits in south Asians. 👉 Read it here:

Whoops, wrong hashtag. If you are going to #ASHG25, check out the line-up! This is perfect if you are a trainee who needs to network but has no idea how to do it. Instead of trying to corner someone at the posters (which is stressful!), schedule a slot and sit down for 15 minutes to chat!

Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

I made a video about my new paper. I hope you enjoy it! vimeo.com/1113132836?s...

Another fun year for the #mwpg, this year at the University of Minnesota! Great to see all the trainees participating with their cool work.

Huge congratulations to my friend @mitopr.bsky.social on being selected as a Pew Biomedical Scholar! www.pew.org/en/projects/...

AlphaSimR course edin.ac/3wfGSEj Week 3 opens with a discussion on genetic variation between relatives, with a focus on siblings. While mutation is the ultimate source of genetic variation (by introducing new alleles), recombination shuffles the existing genetic variation through meiosis.

New in #GENETICS: Huang et al. describe biases in SNP & local ancestry heritability as functions of admixture history and the genetic architecture of the trait, clarifying their interpretation and implication for #GWAS & polygenic prediction in population admixture. Read more: buff.ly/1xB3Mpu

The Mathieson Lab at the University of Pennsylvania is hiring a computational postdoc in machine learning and evolutionary biology. Apply with a CV and references: [email protected]. More info: https://saramathieson.github.io/lab #postdoc

Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans https://www.biorxiv.org/content/10.1101/2025.07.11.664181v1

last day tomorrow to register for a talk/poster at Midwest popgen. Please RT(? is that what they say here?)!

I probably won't have time to make a video out of this. But the materials are available online, and should be pretty self-explanatory. Hope this is useful to some people. privefl.github.io/statgen-cour...

Thrilled to see the latest work from the lab (@genscapelab.bsky.social) out in Current Biology! Congratulations @jaurban2204.bsky.social ! 🎉 Grateful to have had the chance to contribute to this effort.

Please register if you haven't already done so. MidWest PopGen is happening in August at the University of Minnesota (Twin Cities)—abstract deadline for talk: July 11th, and poster: August 1st. sites.google.com/umn.edu/mwpg...

📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9

Website and hotel info for Midwest popgen. Please register (free!) and book rooms asap to get ahead of the State Fair crowd. The world may be aflame but we can try to find some community with each other. #mwpg25 slogan? sites.google.com/umn.edu/mwpg...

Our new work is now out in AJHG "Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples." Great collaboration with @delvecchyo.bsky.social and Emilia Huerta-Sanchez, led by Valeria Añorve-Garibay.

**10th Midwest PopGen Conference** Location: UMN Twin Cities, Date: Aug 21–22! Events: Talks, Posters, dinner + MN State Fair. Register: docs.google.com/forms/d/e/1F... -- Abstracts by June 15 // Register by Aug 1. Add to calendar: calendar.google.com/calendar/eve... #MidwestPopGen

The preliminary program of ProbGen 2026, which will be held at UC Berkeley, is now up: probgen2026.github.io Sharing on behalf of Rasmus Nielsen who is not on this site. For more see his thread on that other site: x.com/ras_nielsen/...

Jennifer Blanc and @jeremyjberg.bsky.social use theory and simulations to study the process of testing for an association between polygenic scores and axes of ancestry variation when confounding factors are present. Learn more about their findings in #GENETICS: buff.ly/EmKpXyP

When should adaptation arise from a polygenic response versus few large effect changes? https://www.biorxiv.org/content/10.1101/2025.05.15.654234v1

Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver

Reminder to folks in genetics/genomics, HGG Advances is a wonderful open-access journal to publish your work in. Consider submitting your latest and greatest with us! :D

Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!

I recently defended my PhD on "Mitochondrial DNA evolution alongside nuclear DNA". Finishing my time at #PennState (with Kateryna Makova, @pennstateuniv.bsky.social), as I transition to the #TwinCities (@mitopr.bsky.social @aazaidi.bsky.social)!

An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.