Now published in Cell! We found that ~15% of SNPs from divergent refs did not liftover as SNPs in the gray fox ref—half mapped to monomorphic sites, half failed to map. Co-authored with Matthew Genchev, @elliecat.bsky.social, and @jazlynmooney.bsky.social www.sciencedirect.com/science/arti...

Super excited to see our reference bias work out in Cell! Reviewers gave us some excellent ideas, and Maria added on some new analyses that broke down how SNPs from heterospecific references mapped or did not map in a conspecific reference.

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

coates is genuinely a generational writer

I have funding for a 2-year dry-lab postdoc to join our team @humanevouu.bsky.social 🧪 (Deadline Oct 21st) The project will utilize modern and #aDNA data from humans and sheep to study environmental adaptation (including method development and simulations). Please share! www.uu.se/en/about-uu/...

Elena Romero led a new preprint detailing joint work with Lillian Cohn's lab at Fred Hutch describing really crazy parallelism in in vivo HIV escape from broadly neutralizing antibodies! #VirEvol #evoSky www.biorxiv.org/content/10.1...

Excited to share that I’ve started as Associate Professor at the Technical University of Denmark! 🧑‍🎓 I also received an a NNF Emerging Investigator grant to use genomics + machine learning to study extinction. 👉 PhD & Postdoc positions coming soon — follow for updates! Reposts appreciated 🙏

Ossoff: Absolutely RFK JR should resign. He should have never been confirmed to begin with. He is utterly unqualified. This is someone who has embraced every piece of quackery and pseudoscience that he’s come across.

Save the date! #PEQG26 June 9-12 2026 in Asilomar, CA. Happens only every 2yrs, but is my favorite conference. Full website coming soon, and registration and abstract submission opens November 14, but I'm allowed to tease that keynotes will be @jnovembre.bsky.social @jennytung.bsky.social and me!

I made a video about my new paper. I hope you enjoy it! vimeo.com/1113132836?s...

Thrilled to share the second half of my PhD work here! We show how data on expression quantitative trait loci (eQTL) relates to the structure of gene regulatory networks (GRN). Much of the GRN / eQTL picture is unmapped, but what we do have says a lot… (1/) doi.org/10.1101/2025...

GHIST 2024: The 1st Genomic History Inference Strategies Tournament https://www.biorxiv.org/content/10.1101/2025.08.05.668560v1

SLiM 5: Eco-evolutionary simulations across multiple chromosomes and full genomes https://www.biorxiv.org/content/10.1101/2025.08.07.669155v1

Unique genetic bases of repeated life-history divergence associated with high altitude adaptation in Mimulus perennials https://www.biorxiv.org/content/10.1101/2025.08.12.669946v1

Introgression and Parental Conflict Underlie Repeated Occurrences of Postzygotic Isolation https://www.biorxiv.org/content/10.1101/2025.08.12.669975v1

📣Online NOW! 📄Estimation of demography and mutation rates from one million haploid genomes 🧑‍🤝‍🧑 @jgschraiber.bsky.social @jeffspence.github.io @docedge.bsky.social

Our paper showing that variation in transcription factor binding sites underlies the majority of additive genetic variance for phenotypic variation in maize is finally out! Sadly they didn't use our suggested cover image below (made by the inimitable Andi Kur). www.nature.com/articles/s41...

Wonderful (and humble) essay on mentorship by Brandon Gaut, on occasion of Brandon receiving the inaugural Mentorship Award of @genetics-gsa.bsky.social. I hope this will be widely read! academic.oup.com/genetics/art...

One of my all-time favorite humans.

I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...

We'll primarily work at the intersection of statistical and population genetics, and we also have active projects related to the ethical and social implications of human genetics (ELSI). Please get in touch if that's a combination that sounds interesting to you!

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

Arun Durvasula, PhD, of @uscpphs.bsky.social writes, "Lifestyle factors play a large role in determining who gets a disease and who doesn’t. But they are far from the entire story." A fascinating read about the relationship between genetics and our environment. ⬇️ 🔗 #Science #MedSky #ResearchSky

If you're new to demographic history inference from population genomics, try this webapp I created to illustrate how dadi fits bottleneck models to site frequency spectra: ryangutenkunst-dadi-two-epoch.hf.space . It even outputs files for submitting to the GHIST competition! ghi.st

🧵 Excited to share a new preprint from our lab looking into signals of disease-burden in aDNA (doi.org/10.1101/2025...)! It has long been speculated that transition to sedentary, agricultural and urbanized lifestyle increases disease burden, but can we see this in aDNA?

Its that time again - the list of Ecology/Evolution/Marine Bio Labs recruiting grad students for Fall 2026 is live! PIs enter your position info here: forms.gle/2XTHBP6CZGEn... Prospective students (and PIs not recruiting) share the composite list: docs.google.com/spreadsheets... Please share! 🧪

In #GENETICS, Williams et al. present a novel statistics—haplotype score—for summarizing identity-by-descent (IBD) sharing that can distinguish half-sibling pairs from avuncular or grandparent-grandchildren pairs and assign individuals to ancestor vs descendant generation. buff.ly/SaZP3CA

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

Having major FOMO about #SMBE2025 in my hometown… but I’m very proud that my postdoc, Susanna Gutierrez, will be presenting our work on inferring the selection history of adaptive introgression candidates in Peruvians at poster S12-P19. Please visit her during poster session 3 if you're interested!

✨ Paper spotlight ✨ (🧵 1/3) Evolution of petal patterning: blooming floral diversity at the microscale nph.onlinelibrary.wiley.com/doi/10.1111/...

🚨BREAKING: Cal State LA just moved classes online and let faculty work remotely, not for a storm, not for COVID, but because ICE is in the area. Let that sink in, an entire university is treating immigration enforcement like a public health crisis.

This is not a budget bill, it is a debt and deportation bill—and one built on the fascist foundation laid by the Heritage Foundation’s now-notorious Project 2025. https://trib.al/1biZ06X

Applications now open! The Graduate Diversity Enrichment Program (GDEP) provides $5,000 over two years to provide PhD students (enrolled in NC Institutions of Higher Education) opportunities for greater science & research enrichment experiences. buff.ly/sJ7c6pI #bwfgdep

We are recruiting students who are thinking of applying to Biology PhD programs this fall to apply for the Stanford Biology Preview Program. Please spread the word!

Excited to kick-off the 2025 Genomic History Inference Strategies Tournament tomorrow at my Evolution workshop! If you're at the meeting, grab a quick lunch and come to the Oconee River 2 room at 1:15 pm on Monday. No prior registration required. ghi.st #Evol2025

And my co-advisee Raya (w/ @arunsethuraman.bsky.social) will be presenting a talk on her software wrapper Coalminer in the Computational Biology II session on June 24. If you like fastsimcoal and are interested in more automated model generation, this talk is for you!

I can't make it to #Evol2025, but please check out my student @elisabethleung.bsky.social's poster in Session 1 (June 22) on 'Evolutionary dynamics of small population recovery in the island fox' about her PhD project plans. We would love feedback and have some awesome data on the way!

More new contributions to fellowships and research job applications! @minyaaa.bsky.social @morgancarterphd.bsky.social @benrlee.com and more github.com/RILAB/statem...

Students attending #Evol2025 Stop by the University of Chicago Press booth to get a free year of American Society of Naturalists student membership and subscription to The American Naturalist. @asn-amnat.bsky.social

So excited to see @alisonfeder.bsky.social among the winners of the freeman hrabowski award!! www.hhmi.org/programs/fre...

Ferrari @jazlynmooney.bsky.social et al. find that while parameter scaling improves efficiency, strong scaling distorts diversity, intensifies background selection, and alters linkage patterns. 🔗 doi.org/10.1093/gbe/evaf097 #genome #evolution #bioinformatics

Excited to share our new paper on genetic differentiation in Atlantic silversides! We investigated how genome structure influences adaptation under varying levels of gene flow using a species-specific reference genome and multiple recombination maps. Read on for insights! doi.org/10.1093/molb... 1/7

@akopyan.bsky.social et al. analysed 168 genomes of Atlantic silverside, showing that high gene flow leads to clustered divergence in large inversions, while low recombination at centromeres mimics differentiation. 🔗 doi.org/10.1093/molb... #evobio #molbio #inversions

“Trump is using military forces to stop a protest — I want y'all to consider what kind of government it appears to be when every time we exercise our democratic right to protest, the military is deployed against us.” Doechii at the #BETAwards

True portraits in courage!

Out today in @pnas.org! www.pnas.org/doi/10.1073/...

Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change

I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.

Now online at @genomebiolevol.bsky.social 🎉 ! academic.oup.com/gbe/advance-...

Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver