Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes https://www.biorxiv.org/content/10.64898/2025.12.05.692665v1

It was a total pleasure to work with @roshnipatel.bsky.social on this, who really led the charge in all respects. Anyone interested in learning about the intersection of population genetics and statistical genetics should check out her new lab in Oregon!

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

"What James Watson got wrong about DNA" By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com). www.bostonglobe.com/2025/11/14/o...

An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social

Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests. We describe a critical concept that we call *specificity*. Led by Jeff Spence and Hakhamanesh Mostafavi:

Why do complex traits differ in their genetic architecture? In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits. Thread: journals.plos.org/plosbiology/...

WOOHOO USC "respectfully declines" the compact as well cc @aaup.org www.latimes.com/california/s...

Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...

Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism www.sciencedirect.com/science/arti...

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

The "You gotta keep 'em separated" line in "Come Out and Play" was inspired by his bench work (for real) www.facebook.com/watch/?v=113...

This is a great opportunity!

I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

Bittersweet to be leaving @docedge.bsky.social after a wonderful postdoc, but excited to share that I'm joining @uoregon.bsky.social next month as an Assistant Professor in the Department of Data Science.

The university of California is a powerhouse of innovation, healthcare, and social mobility for California and the US.

I'm excited to announce that I'll be starting a lab at UCSF in the @ihgatucsf.bsky.social and @ucsf-epibiostat.bsky.social in July. We'll work at the intersection of statistical genetics, population genetics, and machine learning.

Jennifer Blanc and @jeremyjberg.bsky.social use theory and simulations to study the process of testing for an association between polygenic scores and axes of ancestry variation when confounding factors are present. Learn more about their findings in #GENETICS: buff.ly/EmKpXyP

Welcome to the Modeling and Theory in Population Biology workshop! We’re excited to have you join us at NITMB for this week’s event. More information on the workshop and today’s schedule are available at www.nitmb.org/modeling-and...

Harvard has just under 6,800 foreign students enrolled. Every one of them would have to give up their dreams of an education in the US or transfer elsewhere, if Noem's attack on Harvard is upheld. None of them have done anything wrong, they're just collateral damage to Trump.

Excited to share our work on using pathway-specific polygenic scores to discover gene-environment interactions www.medrxiv.org/content/10.1...

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

Amidst all the terrible and terrifying news, so lovely to hear of @jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

In population #GENETICS, Q-ST and F-ST calculations help compare the amount of trait differentiation on one or more traits in genome-wide genetic variants. Using simulations Liu and @docedge.bsky.social, show the effect of various choices made while computing Q-ST. Read more: buff.ly/OwrU9oB

In a new #GENETICS research, @dandanpeng.bsky.social, Mulder, and @docedge.bsky.social evaluate the performance of several ancestral recombination graph (ARG) estimation methods used for determining the historical time course of a population-mean polygenic score. Read more: buff.ly/ztrRU83

I am recruiting a quantitative/computational postdoc to my group at UCLA. This is a great opportunity to work on foundational theory, methods, and software in statistical genetics. Link to apply: recruit.apo.ucla.edu/JPF10275. Please repost!

I'm honoured to have been elected as a member of the American Academy of Arts and Sciences. It's a wonderful recognition of all the hard work by the amazing folks in the lab over the years. A huge thanks to them all.

My paper about type I error rates in Qst/Fst comparisons is now published in @genetics-gsa.bsky.social. Check it out here: academic.oup.com/genetics/adv...

I don’t care whether he’s innocent. I care that he was denied the fundamental human rights of due process and equal protection under the law. Until those conditions are satisfied he is accorded the presumption of innocence.

Inspired by others on here I wrote a short op-ed in support of federal research funding for a local newspaper in small town PA where I grew up

An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.

Editing a genome to Ernst Mayr's genotype so that when clone Ernst grows up, he can tell us whether these are dire wolves

Really excited to see this work, led by Mike Grundler, published! It's a new method for inferring the geographic locations of shared genetic ancestors. In the paper, we and use it to infer the geographic history of human genetic ancestry www.science.org/doi/10.1126/...

A stunning assault on the First Amendment Before Rubio's confirmation, senators and pundits acted as though he was a "sane," "rational," "normal," "moderate" nominee. He's constantly showing himself to be a right-wing extremist.

One problem with the idea of reserving due process for law-abiding people is that due process is how we figure out which people are law-abiding.

1/ Hey y'all, I'm excited to share my latest paper, which is out now in PNAS! We introduce FAVA, a statistical framework to measure compositional variability across microbiome samples. If you want to measure variability across a stacked bar plot, FAVA is for you! Paper: doi.org/10.1073/pnas...

VERY excited to announce a pre-print that represents the culmination of several years of work*: “On ARGs, pedigrees, and genetic relatedness matrices” doi.org/10.1101/2025... Led by Brieuc Lehmann with contributions from @epigenci.bsky.social Luke Anderson Trocme Jerome Kelleher and Peter Ralph

I'm excited to share our new preprint on the molecular evolution of heterodichogamy in two wingnut genera of Juglandaceae. Heterodichogamy features two morphs synchronously alternating male and female flowering phases in time to generate disassortative mating. doi.org/10.1101/2025...

Look, folks, this is it. The entire ballgame. Either we're a Republic of laws & the Constitution, or we have a dictator. This is fascism, & the impeachment vote should be happening today. Every single university president in the country should be out, in front of microphones, condemning this.

This is unconstitutional and unprecedented. But it's consistent with Trump’s desire to stifle protest and silence views he doesn't agree with. With such little regard for the Constitution and case law, it's no surprise that the Trump administration prefers to see what it can get away with.

Dear Manager 1) I have wept and fasted, wept and prayed, 2) I have seen my head (grown slightly bald) brought in upon a platter, 3) I have seen the moment of my greatness flicker, 4) I have seen the eternal Footman hold my coat, and snicker, 5) in short, I was afraid.

Dear manager: 1. We ride with kings on mighty steeds across the devil's plain 2. We've walked with Jesus and his cross; he did not die in vain 3. We've run with wolves 4. We've climbed K2; even stopped a moving train 5. We've traveled through space and time, my friends, to rock this house again

Excited to share a couple of new items (links below): 1. Our work on gene-environment interactions in the UKBiobank is up at the American Journal of Human Genetics 2. Our work on modeling ancient human population size history is up at Molecular Biology and Evolution