I am beyond excited to announce that I will be joining the Dept. of Biosciences at Rice as an Assistant Professor this summer! I’m incredibly grateful to my mentors and colleagues for their guidance and encouragement throughout this journey. More soon—I’ll be recruiting students and postdocs!

Hi Genetics/Comp-Bio community 👋 Interested in mentoring a comp-bio research student in East Africa over the summer? Do you have any experience in bioinformatics, biostats, genome/RNA-seq analyses, ML, or metagenomics? We'd love to have you as a mentor in our new program! 🧵 (1/n)

I am excited to share my first paper, our new preprint: www.biorxiv.org/content/10.6... with @arbelharpak.bsky.social and @docedge.bsky.social. Family GWAS provides direct genetic effect estimates and is increasingly important. But how much can we trust these estimates? (1/15)

Re-upping this: applications we get by next week will get full consideration

Super excited to see this out! Fantastic collaboration with Luke O'Connor and trainees Amber Shen and Xinran Wang. Thread with details will come soon, but linear ARG provide a HIGHLY efficient representation of genotype data that can be treated as a linear operator www.biorxiv.org/content/10.6...

Absolutely fascinating how nearly every teacher and professor I know is now overhauling their pedagogy to put everything on old-fashioned paper, while (and in large part because) massive investments in AI like this roll in. I have no idea what will come of this. www.nytimes.com/2026/05/05/u...

Last weekend I received the Troland Research Award from the @nationalacademies.org. I’m so grateful to the communities who made this work possible. It's strange to receive this award at a time when much of the work being recognized is not eligible for federal funding. My remarks 👇 and a 🧵>>

Congratulations to @jrossibarra.bsky.social on being elected to the National Academy of Sciences! We'll be popping some corn in his honor www.ucdavis.edu/news/nationa...

Over the moon for @jrossibarra.bsky.social ! A great scientist, colleague, and friend. Still terrible puns though.

Please repost: My department at USC is hiring for a teaching-track faculty position. We are looking for someone principally to teach statistics for biologists, but there will be opportunities for other courses in statistics & algorithms applied to biology usccareers.usc.edu/job/los-ange...

This is so unbelievably pathetic

Great postdoc opportunity!

I am hiring a popgen postdoc! Looking for a creative scientist to join us at USC to investigate recessive variation and complex traits in model or non-model species. The project is funded by a multi-year NIH grant, contract can be renewed. Job add & details 👇🏽 usccareers.usc.edu/job/los-ange...

Genome-wide genealogies reveal deep admixtures forming modern humans https://www.biorxiv.org/content/10.64898/2026.04.17.719197v1

For an update on our preprint about the mysterious signature SBS5, see: www.biorxiv.org/content/10.1.... New analyses throughout, but see Figure 5 in particular.

Thrilled to have been able to review 'The Paradox of the Organism: Adaptation and Internal Conflict', a volume edited by @arvidagren.bsky.social & Manus Patten. "...the reality that complex organisms function at all feels like pure magic, with the powers of molecular evolution behind the curtain."

General, orders-of-magnitude faster whole-genome analysis with genotype representation graphs https://www.biorxiv.org/content/10.64898/2026.04.10.717786v1

Delighted to share our latest research from the 23andMe Research Team, just published in @nature.com ! We looked at data from >27,000 participants to uncover how human genetics influences weight loss efficacy and side effects of GLP-1 medications like semaglutide. A short thread 🧵👇

I’m so glad someone covered this story. Brian is an amazing scholar and person who I’ve been blessed to be able to get to know, even a little. What happened to him is awful

Brian Donovan had persuaded high school teachers and education researchers that prejudice might be ended by changing how genetics is taught. www.statnews.com/2026/04/07/b...

Brian and I were grad students together. He's a mensch, and the goons who torpedoed his funding and his livelihood are contemptible.

“We’ve lost out on the ability to continue to improve this work to make it more effective, and to explore how to apply it to other areas…There are a lot of different ways that genetics has been used to justify prejudice and…that human-made social categories interface with biological categories“🧪

We're already losing a generation of scientists because of the things this administration has done. Grad students not admitted, faculty jobs not available. It's a crisis we won't see the cost of for 10 years but we'll feel it

Why do schizophrenia GWAS signals look so flat across the genome? In our recent preprint, we explored why psychiatric disorders — and, more broadly, brain-related traits involving the central nervous system — appear to have unusual genetic architectures. 🧵1/n

The boss

I wrote lectures about DE-EXTINCTION for my human evolution and anthropological genetics courses and have been really popular with students so I decided to turn it into a very long 🧵 I'll post everything as replies here but will try to break into bite size pieces and retweet as I go:

If you research or are simply interested in human genetic variation, ancient and modern, read my and Noah Rosenberg's latest in GENETICS academic.oup.com/genetics/art... 1/2

Excited that our work was featured on the local (Bay Area) news for their Black History month series. Interview with Noah and clips from my interview with @dornsife.usc.edu and CGSI talk in the article below www.nbcbayarea.com/discover-bla...

Promises to be poppin (🍿) BUT SRSLY PLEASE REGISTER, WE ARE SO EXCITED!!!!!!!!!!!!

New work from the lab: Miles @milesroberts.bsky.social tried out machine learning to estimate sweep times to fixation and (spoilers) it didn't really help www.biorxiv.org/content/10.6... As always, we'd appreciate any feedback!

The Guerrero Lab at NC State University seeks a postdoc in computational evolutionary genetics. Ideal candidates have quantitative skills. Apply by March 10, 2026, via [email protected]. More info: rguerrer.org #postdoc

Congrats @jeffgroh.bsky.social et al. Some avocado trees open female-phase flowers in the morning & then male in afternoon. Others show complementary pattern (m->f), to synchronize pollination of two types. Jeff show this to be a >45Mya polymorphism at a transcription factor across 100s of species.

Happy to highlight an essay I wrote together with @marcdemanuel.bsky.social, @natanaels.bsky.social and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species: www.biorxiv.org/content/10.6... 1/n

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes https://www.biorxiv.org/content/10.64898/2025.12.05.692665v1

It was a total pleasure to work with @roshnipatel.bsky.social on this, who really led the charge in all respects. Anyone interested in learning about the intersection of population genetics and statistical genetics should check out her new lab in Oregon!

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

"What James Watson got wrong about DNA" By the great Sohini Ramachandran (@sramach.bsky.social) and your boy for The Boston Globe (@bostonglobe.com). www.bostonglobe.com/2025/11/14/o...

An empirical approach to evaluating the prevalence of long-lived balancing selection in humans--and important limitations. Work by @hannahmm.bsky.social

Excited to share our latest work on the factors that determine what genes we find (and don't find!) in GWAS and burden tests. We describe a critical concept that we call *specificity*. Led by Jeff Spence and Hakhamanesh Mostafavi:

Why do complex traits differ in their genetic architecture? In our new PLOS Biology paper, we will try to convince you that two simple scaling laws drive differences in the number, effect sizes and frequencies of causal variants affecting complex traits. Thread: journals.plos.org/plosbiology/...

Sharing our new paper, "Distinct haplotypes and reversed dominance at a single-gene balanced polymorphism controlling heterodichogamy in two genera of wingnuts". Genomics & evolution of a mating type system involving two morphs with alternating sexes in walnut relatives www.cell.com/current-biol...

Congratulations to @jeffgroh.bsky.social on the publication of his paper on an ancient balanced polymorphisms controlling heterodichogamy in two genera of wingnuts. The paper shows the putative turnover & reversal of dominance of a mating type polymorphism www.sciencedirect.com/science/arti...

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

The "You gotta keep 'em separated" line in "Come Out and Play" was inspired by his bench work (for real) www.facebook.com/watch/?v=113...

This is a great opportunity!

I'm recruiting a postdoc for my group (based in beautiful Eugene, OR). Please get in touch if you're interested, esp if you'd like to chat at #ASHG25!

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...