I’m honored and excited to join the Board of Directors! IGES is home to such a vibrant and welcoming scientific community, I look forward to helping it continue to thrive! 💟🧬 Join us for IGES 2026 in beautiful Estérel, QC 🍁 Abstract submission is open until May 30 www.geneticepi.org/2026-annual-...

This is an amazing repository of datasets that are helpful to self educate on key #stats principles

G-EE A very much needed (and brilliant) reflection for Mendelian randomization

“SVM, NN and RF may need over 10 times as many events per variable to achieve a stable AUC and a small optimism than classical modelling techniques such as LR. This implies that such modern techniques should only be used in medical prediction problems if very large data sets are available.“ #stats

power analysis? 👇this

matter of (dis)trust and control Statistics reach a 'crisis point': nations struggle with a critical lack of data www.nature.com/articles/d41...

I build a feed for european grant funding that's updated daily and (IMO) far more transparent then the official EU fundign website: michelnivard.github.io/eu-grants-fe... (inspired by the NIH equivalent @sashagusevposts.bsky.social build yesterday)

Here's our R package for interacting with WGS derived GWAS summary statistics with many rare variants (from e.g. UKB or AofUs). It uses duckdb underneath so it's fast. Includes some helpful tie ins to Open Targets / Encode Screen / Ensembl APIs for annotation. weinstocklab.github.io/gwasplot/ind...

On the importance of longitudinal studies

Are you interested in understanding how social and structural determinants of health influence estimates of genetic risk? Looking for figures for teaching these concepts? Check out our work on considerations for modeling them together, led by Sara Cromer and Dave Conti with @prsmethods.bsky.social

Great to see this work out, led by Jon Rosen and co-supervised Karen Mohlke @klmohlke.bsky.social! Connecting to some recent threads here:

"Losing my institutional email address felt like losing a small but vital piece of the scientist I had become." #ScienceWorkingLife https://scim.ag/3OGpS67

One of the best explanations of 2-sample MR using simple statistical notation. And a new method, outperforming previous ones in term of power and type I error. #stats #geneticepi

A Little Book of R for Multivariate Analysis by Avril Coghlan #RStats https://bigbookofr.com/chapters/statistics.html#a-little-book-of-r-for-multivariate-analysis

RWE, the ‘illusion of the real’

Our new preprint “Learning lifetime disease liability reveals and removes genetic confounding in electronic health records” is now online! Link to paper: This work is led by my postdoc Yazheng Di and it’s our first project at @bsse.ethz.ch :) medrxiv.org/cgi/content/... Thread 1/n

Ph.D. defense time! @ LUMC, our former student @dariushghasemi.bsky.social successfully defended his thesis, where he investigated several methods to interpret genetic loci for #CKD

I've also heard "my associational study is only to see whether someone should do a causal study later." The best way to create evidence for whether one should do a, potentially better, causal study later, is to do everything that that hypothetical future causal study would do.

Our editorial about climate change...yes, it's coming and it's not stopping...and its effect on kidney stones, AKI, CKD...(while USG remains in denial: promoting COAL!) in @kireports.bsky.social www.sciencedirect.com/science/arti... @theisn.org @nyunephro.bsky.social @thecookingdoctor.bsky.social

Measurement error in nephrology /1: - at low creatinine levels, Jaffé >> enzymatic creatinine - glucose is associated with Jaffé - Enzymatic difference #ckd academic.oup.com/jalm/article...

Not all kidney function estimating equations work the same (also, curious distribution of the EKFC eGFR in this paper) academic.oup.com/ndt/article/... #CKD #EKFC

✅ The UK Government has today granted access to half a million UK Biobank participants' coded GP data for health research. This change will dramatically increase the power of UK Biobank's dataset to advance the diagnosis, treatment and management of conditions handled by GPs.

🚨Eurac MSCA Postdoctoral Fellowship scouting has started - get in touch if you'd like to submit a proposal with me 📝 www.eurac.edu/en/research-... #MSCA

Evidence of absence or absence of evidence? www.thelancet.com/journals/lan...

"The switch" - a nice story by Valentina Bergonzi on our research on #desmoplakin & #ECG arrhythmias traits 🖱️ www.eurac.edu/en/magazine/...

Preprint with the results of genome-wide eQTL analyses across 43,301 blood samples from the eQTLGen Consortium is now online! A major collaborative effort- many thanks to everyone involved, especially @robertwarmerdam.bsky.social, @ludefranke.bsky.social, and all eQTLGen collaborators!👇

Dichotomizing continuous outcomes in RCTs can be wasteful, costly, and unethical

Registration is now open! See: csama2026.bioconductor.eu/registration...

focus on modifiable risk factors www.nature.com/articles/s41...

Excited to share our review in #KIReports – a real milestone for me! #CKD at the Crossroads: From Failure to Future Therapies 1️⃣ Current & emerging CKD therapies 2️⃣ Why proven treatments are still underused 3️⃣ Practical checklist to help clinicians implement kidney protective therapies in practice

“Scientific integrity is essential to a functioning democracy.” Our friends at @ucs.org explain how authoritarianism chips away at truth piece by piece—attacking science, silencing experts, and weaponizing propaganda—and lay out what scientists can do to defend democracy, starting now. ⬇️

Slim 5 can now simulate genomes with multiple chromosomes like autosomes, sex chromosomes, mitochondria and chloroplast dna academic.oup.com/mbe/article/...

Heritability = a statistical description of sources of interindividual variation in a specific set of people under a specific set of environmental conditions. It doesn't index a fixed underlying feature of human biology. A few lines in this paper acknowledge that but its overall framing may mislead.

KidneyGen Africa 1st workshop, here we are! 🛬 www.kidneygenafrica.org/workshops #kidney #genetics #africa #ckd

Incredibly important story that everyone should read. These are not disorganized lone actors, but well-funded and powerful networks to be treated as serious threats. They are using our work to push a eugenicist and racist agenda that is scientifically invalid and morally reprehensible.

We’re recruiting a data science programme lead to help develop and deliver a bold data science and AI strategy that will position us at the forefront of innovation. For the full job description and to apply, click here: https://bit.ly/4rrsEKL

This looks interesting: Rscript -> .qmd

Tutorial in Biostatistics Mendelian Randomization Methods for Causal Inference: Estimands, Identification and Inference. Minhao Yao, Anqi Wang, Xihao Li, Zhonghua Liu. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...

The Methods Series @ki.se is back! @epiellie.bsky.social kicks off the 2026 speaker lineup next Tuesday, "How do we actually draw a causal graph? A proposal for evidence-based best practices." 📆 Jan 27, 2026 ⏰ 15.00 CET/9.00 EST 📍 Online Register to attend 👇 stats.sender.net/forms/e7JD1d...

📣 🧬🦠 New article out on genetic susceptibility to infection with Omicron variants of SARS-CoV-2. In this international GWAS meta-analysis, we identified loci not found for earlier variants of the virus. The findings point to a central role of glycosylation. 👇 www.nature.com/articles/s41...

Really honored that our kidney volume genetics paper is accompanied by an editorial commentary in the Feb issue of @kidneyint.bsky.social. Many thanks to @cpattaro.bsky.social & Belen Ponte for the thoughtful perspective, and to all collaborators who made this work possible #CKD #DeepLearning #GWAS

In the new issue of @kidneyint.bsky.social you can find a little commentary that I had the pleasure to coauthor with Belen Ponte: "Genomics of kidney volumes: one size does not fit all" www.sciencedirect.com/science/arti...

to him we probably owe the first definition of uniform distribution #statssky

🚀 Introducing the "HT Seminars: Connecting Discoveries"! A new series bringing leading international researchers to Milan to explore what’s next in life sciences. Across disciplines, perspectives and technologies. Calendar & Registrations 👉 humantechnopole.it/en/training/... #HTseminars

New paper "Variant selection to maximize variance explained in cis-Mendelian randomization" led by @AngZhou3 and published at @HGGAdvances: pubmed.ncbi.nlm.nih.gov/41548043/, with contribution from @vkarhune.bsky.social, Haodong, Janne, Ash, and Eric. Brief thread:

Causal Genotype–Phenotype Relationships from Population-Sampled Parent–Child Trios: TMT and TDT onlinelibrary.wiley.com/doi/10.1002/... #statgen

Just finished reading 'Epidemiology: An Introduction' (3rd ed.) by KJ Rothman, KF Huybrechts and EJ Murray (@epiellie.bsky.social). What an excellent book. I especially loved those little boxes explaining, for instance, why p-values in the Table 1 of RCTs make no sense. Congrats for the great work!

Reports said the trial was halted. HHS says it will proceed. The revised protocol remains unethical. Scrutiny must continue until participants are no longer placed in harm’s way. I read the revised protocol and wrote a follow-up. bktitanji.substack.com/p/lipstick-o...

Very proud that Eurac Research has joined the Scholars at Risk network! www.scholarsatrisk.org #EuracResearch