Every machine in a Hospital that diagnoses your body without cutting you open is based on a principle of Physics, discovered by a Physicist who had no interest in Medicine. If you think the world doesn’t need Basic Science, or that somehow Science has failed you, think again. #sciencematters

Data are there. Methods are there. And the missing heritability issue is nearly over. All in this beautifully-written piece

new genomic annotation resource by Christopher E Gillies et al: Variant Classification Using Proteomics‐Informed Large Language Models Increases Power of Rare Variant Association Studies and Enhances Target Discovery onlinelibrary.wiley.com/doi/10.1002/... w github repo github.com/rgcgithub/es...

“Promiscuous dichotomisation is yet another way of torturing the data to produce false confessions of which we must be eternally wary.” #statistics #P-hacking #stats

Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders rdcu.be/ePmwD

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

On “Confirmatory” Methodological Research in Statistics and Related Fields. F. J. D. Lange, Juliane C. Wilcke, Sabine Hoffmann, Moritz Herrmann, Anne-Laure Boulesteix. Statistics in Medicine. onlinelibrary.wiley.com/doi/10.1002/...

Is It Time to Consider Population-Based Urine Dipstick Screening for Early Detection of Kidney Disease? ca. 2025 from @kireports.bsky.social @saynanorouzi.bsky.social #Nephpearls #KidneyWk #NephSky 👉 www.kireports.org/article/S246...

I am deeply honored to have been awarded the European Hormone Medal 2026!

Galton calling for data sharing in 1901 - does anyone know of earlier examples?

🚨 Job Market Alert 🚨 The Department of Economics of the University of Bologna invites applications for a fixed-term Assistant Professor position **any field** starting AY 2026/27. 📅 Apply by Nov 10 💼 6-year contract, low teaching load, no Italian required. Info: econjobmarket.org/positions/11...

Glad to see this! I’ve long preferred a single robust well thought-out model that includes terms for things we know we don’t know such as interactions and nonlinearity of predictor effects. Bayesian models use skeptical priors for complexities we hope we don’t need. #StatsSky

Further evidence that race and ethnicity are social constructs: at the same level of genetic admixture, self-assigned race/ethnicity varies by ancestry, with age also playing a role in the self-classification process #popgen onlinelibrary.wiley.com/doi/10.1002/...

#rstats #dataviz Over 30 years ago, when I was doing graphics with #SAS, I imagined traveling in color space and computing meaningful palettes. I ranted that: Every time you are forced to say “#008B8B” or “cyan4” a puppy dies somewhere

Another great paper and neat analysis from Andrea's group 👏

1/7 New BMI GWAS out! Using Estonian Biobank (n=204,747) and replication in FinnGen, we show that even in Europe you can still find region-specific biology if you zoom into population-tailored sumstats. Big thanks to co-author @kanwalbatool.bsky.social :)

In a new "Mechanisms of Kidney Disease" article in #ASNJASN, authors explore population studies and the genetic architecture of kidney diseases, highlighting a spectrum of risk. Read more: kidney.pub/JASN0893#ASNJASN, @dannygale.bsky.social

Briefly the two measures must already be perfectly transformed, there be no floor or ceiling effects, and difference must be unrelated to baseline. Details at hbiostat.org/bbr/change #Statistics #StatsSky

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal. Please consider submitting your work in genetics/genomics with us!

"a polygenic score, by design, is acausal. It is a correlation accumulator"

"dependence is the modal human condition"

Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue Unclear biological rationale supporting valid application of MR to the research question 😶 Decision by journal+publisher. Authors disagree onlinelibrary.wiley.com/toc/16000846...

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here jobs.silkroad.com/NYGenome/Car...

📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish) Do PCSK9 levels affect survival in breast cancer patients? We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.

Towards race-free predictive formulas: a path that should not be abandoned www.nejm.org/doi/full/10....

reflections on #sociogenomics #popgen www.cell.com/trends/genet...

Very nice application of factor analysis #stats

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

keywords for innovative science: rookie & diversity www.nature.com/articles/d41...

the Trials within Cohort (TwiC) design: www.jclinepi.com/article/S089...

SAFE-LD: A novel method for the estimation of linkage disequilibrium from summary statistics https://www.biorxiv.org/content/10.1101/2025.09.29.679154v1

Why scientists should take more coffee breaks www.science.org/content/arti...

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new study in Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting progression • Lifespan PRS predicts survival better

A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...

"ignoring political issues that affect health means ignoring real barriers to care" www.thelancet.com/journals/lan...

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

#OTD 1876 Edith Abbott b (d 28 Jul 1957) ASA Fellow 1945. One of the 1st F deans in the US, she pioneered statistical methods applied to policy development for welfare, education & protections for immigrants, working women & children

The Health Data Science Centre at @humantechnopole.bsky.social is looking for an outstanding Postdoc to work on Generative Machine Learning for biomedical data. If you are passionate about ML and real-world health data, this is the position for you! info: [email protected] tinyurl.com/5n8yy7xp

1. e.g. pmc.ncbi.nlm.nih.gov/articles/PMC... 2. jamanetwork.com/journals/jam... For expert advice on using tylenol during pregnancy: www.acog.org/clinical/cli...

In modern datasets, very large sample sizes combined with slight differences in information across SNPs (eg die to imputation) can mislead fine mapping algorithms, and in turn colocalisation.

Cool method to exploring the #omnigenic architecture of complex traits www.cell.com/ajhg/fulltex...

We often try to put rare genetic diseases & common diseases into context wrt some genetic finding. Here, a helpful review on how rare variants may alter common disease risk & viceversa, how common disease genetic background influence rare/genetic diseases www.sciencedirect.com/science/arti...

Reviving an often forgotten topic: #Bias due to participant overlap in two-sample #MendelianRandomization onlinelibrary.wiley.com/doi/10.1002/...

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

A Genetic Atlas of the Mammary Gland 🧬🤱🐭 New research from @geula.bsky.social & team shows shifts in gene activity across pregnancy → lactation → weaning. This new 'atlas' provides new avenues for studying lactation disorders and breast cancer. academic.oup.com/nar/article/...

After publishing its founding paper, #KidneyGenAfrica is now ready for its 1st Training Workshop in #CKD #genetic #epidemiology, dedicated to researchers based in Africa, on Jan 25-30, 2026, in South Africa. More details here www.kidneygenafrica.org/kidneygenafr... www.linkedin.com/feed/update/...

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

and a preprint with some more info on the #Spectra infrastructure and #SpectriPy : doi.org/10.31219/osf...

📣3-year bioinformatics position open @ our Institute to work w outstanding @jorainer.bsky.social on #metabolomics data data data #rstats