the Trials within Cohort (TwiC) design: www.jclinepi.com/article/S089...

SAFE-LD: A novel method for the estimation of linkage disequilibrium from summary statistics https://www.biorxiv.org/content/10.1101/2025.09.29.679154v1

Why scientists should take more coffee breaks www.science.org/content/arti...

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new study in Nature Genetics including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting progression • Lifespan PRS predicts survival better

A pretty comprehensive comparison of most actual #proteomics platforms: Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery www.nature.com/articles/s42...

"ignoring political issues that affect health means ignoring real barriers to care" www.thelancet.com/journals/lan...

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

#OTD 1876 Edith Abbott b (d 28 Jul 1957) ASA Fellow 1945. One of the 1st F deans in the US, she pioneered statistical methods applied to policy development for welfare, education & protections for immigrants, working women & children

The Health Data Science Centre at @humantechnopole.bsky.social is looking for an outstanding Postdoc to work on Generative Machine Learning for biomedical data. If you are passionate about ML and real-world health data, this is the position for you! info: [email protected] tinyurl.com/5n8yy7xp

1. e.g. pmc.ncbi.nlm.nih.gov/articles/PMC... 2. jamanetwork.com/journals/jam... For expert advice on using tylenol during pregnancy: www.acog.org/clinical/cli...

In modern datasets, very large sample sizes combined with slight differences in information across SNPs (eg die to imputation) can mislead fine mapping algorithms, and in turn colocalisation.

Cool method to exploring the #omnigenic architecture of complex traits www.cell.com/ajhg/fulltex...

We often try to put rare genetic diseases & common diseases into context wrt some genetic finding. Here, a helpful review on how rare variants may alter common disease risk & viceversa, how common disease genetic background influence rare/genetic diseases www.sciencedirect.com/science/arti...

Reviving an often forgotten topic: #Bias due to participant overlap in two-sample #MendelianRandomization onlinelibrary.wiley.com/doi/10.1002/...

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics. www.biorxiv.org/content/10.1... (1/n)

A Genetic Atlas of the Mammary Gland 🧬🤱🐭 New research from @geula.bsky.social & team shows shifts in gene activity across pregnancy → lactation → weaning. This new 'atlas' provides new avenues for studying lactation disorders and breast cancer. academic.oup.com/nar/article/...

After publishing its founding paper, #KidneyGenAfrica is now ready for its 1st Training Workshop in #CKD #genetic #epidemiology, dedicated to researchers based in Africa, on Jan 25-30, 2026, in South Africa. More details here www.kidneygenafrica.org/kidneygenafr... www.linkedin.com/feed/update/...

A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...

and a preprint with some more info on the #Spectra infrastructure and #SpectriPy : doi.org/10.31219/osf...

📣3-year bioinformatics position open @ our Institute to work w outstanding @jorainer.bsky.social on #metabolomics data data data #rstats

Couldn't agree more. The #R real superpower

🚀 Book in progress: Spatial Data Visualization with tmap A guide to creating thematic maps in R with the tmap package. Covers everything from loading data to interactive and animated maps, with reproducible code. Read online: tmap.geocompx.org #rstats #rspatial #geocompx #gischat #maps

CALL FOR FACULTY PROPOSALS Do you have a project that could offer a comprehensive #research & #training experience to a postdoc in #statisticalsciences? Submit your proposal to the CANSSI Distinguished #Postdoctoral #Fellowships program by October 1: https://loom.ly/GvcQVII

Not all pathogenic variants are in coding regions! 👀 📢 This review highlights Mendelian disease-causing UTR variants, their mechanisms, and implications for clinical interpretation. 🧬 #Mendelian #UTRvariants #ejhg www.nature.com/articles/s41...

somewhat related www.sciencedirect.com/science/arti... in @kireports.bsky.social see how less often do we think of TKD (4%) but how often it turns out to be (19%) #NephSky

Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...

1/ New report from @bentleyallan.bsky.social's Net Zero Policy Lab: As the US withdraws from green tech industries and pressures allies to follow suit, China is stepping in to power the developing world's energy transition. The scale is staggering. www.netzeropolicylab.com/china-green-...

Really looking forward to this

A new model sheds light on the seasonal dynamics of plague in Madagascar — a step toward better prevention through a One Health approach. 🔗 Read more: www.pasteur.fr/en/research-... @scauchemez.bsky.social @abrault.bsky.social @fanohi.bsky.social

GLMcat: An R Package for Generalized Linear Models for Categorical Responses. Lorena León, Jean Peyhardi, Catherine Trottier. Journal of Statistical Software. www.jstatsoft.org/article/view...

Court staff cover up Banksy image of judge beating a protester

🚂 Traveling to the 13th Congress of Italian Society of Medical Statistics & Clinical Epidemiology (SISMEC) #SISMEC2025 The exciting program is full of Causal Inference & AI 👇 Looking fwd many interesting discussions www.sismec.info/congresso202...

Please take a moment to tell us how you use the Genome Browser: surveymars.com/q/mnb... Your feedback supports future improvements and our continued funding.

This

New online! Harnessing functional annotation to improve the accuracy and transferability of polygenic scores

Welcome back students! Joining us from 29 different countries hailing from 6 continents across the various degree programs are: 72 PhD students, 15 SM1 students, 13 SM1 summer-only students, 62 SM2 students, and 76 MPH Epi students in the Department of Epidemiology @hsph.harvard.edu.

Excited to share our latest manuscript, "Exposure accumulation drives age-dependent disease architectures and polygenic risk scores," led by Xilin Jiang: www.medrxiv.org/content/10.1... I am attempting an explainer thread for the first time here: (I am usually too exhausted to post one)

Excited for this to finally see the light of day - new preprint from my lab, where we present a fast, accurate maximum likelihood tool to estimate population structure, called MULTICLUST. We extend the model of Alexander et al 2009 (ADMIXTURE) to multiallelic data. www.biorxiv.org/content/10.1...

📣New from Zhang et al! 📄Knockoff procedure improves susceptibility gene identifications in conditional #TWAS

Multi-ancestry GWAS can increase power and precision, but how should we analyze them? Pooled or stratified? We answer that question in a paper out today in AJHG, led by Julie Dias and Haoyu Zhang. 1/7 www.cell.com/ajhg/fulltex...

In the last day of #IGES2025 I noted a couple of promising software packages 👨‍💻 I'd like to keep an 👁️ on: - pop-gwas - HVAC

The ESHG calls for caution regarding the proposed use of the SRY gene test in sport. Eligibility rules must acknowledge biological complexity, allow for exceptions, and ensure proper athlete support. Read the full statement:

Why bother w genetics and epidemiology if we have chocolate? (the Cologne chocolate museum) #IGES2025

Association of Serum Afamin Concentrations With Kidney Failure in Patients With CKD: Findings From the German CKD Cohort Study bit.ly/4fWGYES #OpenAccess #VisualAbstract

News for #CKD and ##T2D treatment #finerenone #empagliflozin #nephjc www.nejm.org/doi/full/10....

#IGES2025 Jakob Woerner @jakobwoerner.bsky.social brilliantly outlines tradeoffs btw proteomics scores & polygenic scores in incident disease prediction. Lots of hints from his paper 👇 www.medrxiv.org/content/10.1...

#IGES2025 highlights its friendship w @canssi-incass.bsky.social , which is expanding its efforts towards statistical methods for #statgen Worth looking at programs canssi.ca

#Cologne #Köln #IGES2025 😀

The most fundamental scientific discoveries happen to answer real 🌍 needs. Choleski matrix decomposition was developed in war times to identify the exact locations of enemy's fire spots as fast as possible, applying geodetics to poor resolution & biased air 📷s #maths #stats 👉 h1.nu/18ghZ