Great to be involved in this publication: "Phenome-wide study on alcohol consumption provides genetic evidence for a causal association with multiple diseases and biomarkers" led by Nigussie Kassaw - doi.org/10.1016/j.nu....

New preprint: "Revising the use of F-tests in weak instrument practice: point estimation and beyond" led by James Lane: papers.ssrn.com/sol3/papers..... The F>10 threshold for avoiding weak instrument bias has almost mythical status. But where does it come from? And does it make sense? In brief:

New pre-print: "Correcting for effect modification in the doubly-ranked non-linear Mendelian randomization method" led by Ang Zhou available at www.medrxiv.org/content/10.6.... Brief thread:

LD patterns can make it difficult to select optimal instrumental variables for Mendelian randomization studies. @stevesphd.bsky.social & co of @hggadvances.bsky.social 's latest article evaluate the ability of four selection methods to increase instrument strength: bit.ly/4a0yXih #ASHG

New paper: "Extending the Use of Mendelian Randomisation With Non-Inherited Variants to Assess Socially Transmitted Parental Exposures Under Assortative Mating" published at Genetic Epidemiology and led by Benji Woolf: onlinelibrary.wiley.com/doi/10.1002/.... Brief thread:

New paper "Variant selection to maximize variance explained in cis-Mendelian randomization" led by @AngZhou3 and published at @HGGAdvances: pubmed.ncbi.nlm.nih.gov/41548043/, with contribution from @vkarhune.bsky.social, Haodong, Janne, Ash, and Eric. Brief thread:

New paper: "Alcohol consumption and risk of cancer: a Mendelian randomization analysis of four biobanks and consortium data" out at BMC Medicine: link.springer.com/article/10.1.... Lots of interesting findings! Brief thread:

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

Happy to have co-authored a technical report published by @Policy_Exchange on University Technical Colleges. My role was limited to the statistical report, not the policy document - although I proof read the latter to ensure our analyses was correctly represented.

New pre-print: "Systematic comparison of colocalization methods using protein quantitative trait loci" led by @hwang_seongwon at www.biorxiv.org/content/10.1.... Which method does best? Find out!

New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason.bsky.social on - arxiv.org/abs/2510.17554

New pre-print: "PCSK9 and breast cancer survival: a Mendelian Randomization study" www.medrxiv.org/content/10.1... led by Janne Pott. Brief thread:

Full recording of the PSI webinar by myself and @jack_bowdenjack on instrumental variable methods is available online: psiweb.org/vod/item/efs...

A pre-print for Chris Wallace's colocPropTest method for proportional colocalization is available online: www.biorxiv.org/content/10.1... @chr1sw.bsky.social

New manuscript led by @BarWoolf "A cautionary note on the naive use of general-population biobanks to study pulmonary arterial hypertension" is now published at Euro Respiratory Journal @ERSpublications: pubmed.ncbi.nlm.nih.gov/40967765/. Summary follows:

New pre-print online: "Context-stratified Mendelian randomization: exploiting regional exposure variation to explore causal effect heterogeneity and non-linearity", arxiv.org/abs/2507.11088. We propose an alternative approach to assess non-linearity in Mendelian randomization.

New paper led by Nasir Bashir "Periodontitis and Systemic Disease: The Impact of Covariate Selection" published at @JDentRes: journals.sagepub.com/doi/10.1177/.... We investigate how disease associations vary with covariate adjustment.

New publication at @BMJMedicine "Epidemiology: a partnership of technical expertise and clinical insight" co-authored with Debbie Lawlor: bmjmedicine.bmj.com/content/4/1/.... This essay explores how to be an epidemiologist is in today's world. Comments welcome!

New publication at European Journal of Epidemiology: "Search for common genetic variants to allow reliable Mendelian randomization investigations into ketone metabolism" led by Zhu Liduzi (Julie) Jiesisibieke. Link: link.springer.com/article/10.1.... Brief thread:

Krista and I are giving an introduction to Mendelian randomization in Brown 3 starting in a few moments - I will post my slides here after the session #eshg2025

New paper published at AJE Advances: "The role of estimation in Mendelian randomization: should Mendelian randomization investigations provide estimates?" led by @BarWoolf and myself: academic.oup.com/ajeadvances/.... Brief thread:

New pre-print: "Mendelian Randomization with longitudinal exposure data: simulation study and real data application" led by Janne Pott is online: medrxiv.org/content/10.1.... Brief thread:

Our paper "A Principled Framework for Mendelian Randomization in Oral Health Research" led by Nasir Bashir is now online at Journal of Periodontal Research: onlinelibrary.wiley.com/doi/10.1111/.... Brief thread follows!

The Mendelian Randomization course turns 10! 🥳 This March marks a significant milestone for the popular short course run by the BSU, as it enters its 10th year. Read more 👇 www.mrc-bsu.cam.ac.uk/news/mendeli... @stevesphd.bsky.social

Following the recent trial showing GLP1R agonists may reduce alcohol use disorder, happy to share that the Mendelian randomization evidence supports beneficial effects of GLP1R treatment on substance use disorders and AUDIT score + other outcomes: www.medrxiv.org/content/10.1....

New pre-print led by @hwang_seongwon: "Human genetics suggests differing causal pathways from HMGCR inhibition to coronary artery disease and type 2 diabetes": www.medrxiv.org/content/10.1.... Brief thread follows:

Registration is now open for our 2025 Genetics in Drug Development course: onlinesales.admin.cam.ac.uk/conferences-.... Details about the course are here: www.mendelianrandomization.com/index.php/co....

Our work on immortal time bias "Illustrating the structures of bias from immortal time using directed acyclic graphs" led by Emma Guoyi Yang @yanggy_hku is out at International Journal of Epidemiology: doi.org/10.1093/ije/.... Brief thread: