Pilar Cacheiro
@pilarcacheiro.bsky.social
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Computational biologist. Genetics of Rare Diseases, Essential Genes, Statistics, R. Honesty matters.
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Pilar Cacheiro
Tom Albright
24 days ago
Whether we like it or not, AI is here and not going anywhere. The excellent colleagues behind
@callingbullshit.bsky.social
(
@jevinwest.bsky.social
&
@carlbergstrom.com
) now have a great resource to help us understand AI and how to deal with it. Highly recommended!
thebullshitmachines.com/index.html
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Nature
27 days ago
A common type of ant in Europe breaks a fundamental rule in biology: its queens can produce male offspring that are a whole different species
go.nature.com/4mOb5T9
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‘Almost unimaginable’: these ants are different species but share a mother
Ant queens of one species clone ants of another to create hybrid workers that do their bidding.
https://go.nature.com/4mOb5T9
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Craig Kaplan
27 days ago
Look at this crazy thing!
www.nature.com/articles/s41...
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One mother for two species via obligate cross-species cloning in ants - Nature
In a case of obligate cross-species cloning, female ants of Messor ibericus need to clone males of Messor structor to obtain sperm for producing the worker caste, resulting in males from the same moth...
https://www.nature.com/articles/s41586-025-09425-w
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One of those days when you feel very lucky to have the job you do. Everyone is working hard, your colleagues go the extra mike to support you, and things work out, even if at the last minute.
about 1 month ago
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I guess art is there for us to agree or disagree with.
about 2 months ago
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My one and only reply from now on to anyone making fun of Spaniards for their siesta habits.
journals.plos.org/plosbiology/...
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N2 sleep promotes the occurrence of ‘aha’ moments in a perceptual insight task
Sleep supports memory consolidation, but can it also facilitate memory reorganization? This study reveals that N2 sleep, but not N1 sleep during a nap, increases the likelihood of having an 'aha' mome...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003185
about 2 months ago
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Michael Love
about 2 months ago
This sounds true to me
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Brian Bilston
about 2 months ago
The mathematician John Venn was born on this day in 1834. To commemorate the occasion, here’s a poem in the form of a Venn diagram.
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If I ever get rich I won't tell anyone, but there will be signs.
about 2 months ago
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So long, and thanks for all the fish.
2 months ago
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Not entirely sure what the lunch menu is, but it sure made fishing look easy.
2 months ago
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If you were a gannet, where would you want to live?
2 months ago
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We all need a rest sometimes.
2 months ago
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Simon Fisher
2 months ago
Telomere-to-telomere DNA sequencing is set to transform the field of human genetics in coming years. For a flavour of what's coming, see this exciting work on nearly complete genomes of 65 individuals from diverse populations, out today in
@nature.com
by
@glennislogsdon.bsky.social
& colleagues. 👇🧬🧪
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Complex genetic variation in nearly complete human genomes - Nature
Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
https://www.nature.com/articles/s41586-025-09140-6
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MRC Laboratory of Medical Sciences
2 months ago
📢 We're hiring 5 postdocs across multiple projects! Spanning germline demethylation, gene regulation and genome architecture in development and disease! Apply now!
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MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences
Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.
https://lms.mrc.ac.uk/work/vacancies/mrc-postdoctoral-research-scientists-x-5/
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Doug Fowler
2 months ago
Interested in using functional data to understand clinical variants? Been hunting for a good review of the topic? We just wrote one!
rdcu.be/exaEU
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Multiplexed assays of variant effect for clinical variant interpretation
Nature Reviews Genetics - Multiplexed assays of variant effect (MAVEs) are highly scalable experimental approaches used to generate functional data for genetic variants. In this Review, McEwen et...
https://www.nature.com/articles/s41576-025-00870-x.epdf?sharing_token=v0CPDaCKpk7r5W5jMnGWNdRgN0jAjWel9jnR3ZoTv0MnIq6f9qgmeoIbzF7Yzo2dnJugRVV4uytQjlPei91o7P8-jmfy3pfEn-QPWx8TxU6I9fsa5G6LkUYWP1fpoZCZcdAMd1PfQZG9Rxyt8yD-kqdyiqoy607NMF3TIo9ojfw%3D
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Prof Cath Noakes
2 months ago
Remember folks, your AI is only as good as the training data and so it looks backwards rather than forwards….
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Walking back home so deep in my thoughts that the corner shop guy stops me to ask: is everything ok? So this is my face after an actually very good day. I don't want to imagine how I look after a bad one.
2 months ago
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Saloni
3 months ago
Sometimes 8:30pm in London looks like this
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as a clear blue sky all my favourite people somehow just feel right
3 months ago
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Literland
3 months ago
"Tan absurdo y fugaz es nuestro paso por el mundo, que solo me deja tranquila el saber que he sido auténtica, que he logrado ser lo mas parecida a mí misma que he podido”. En recuerdo de Magdalena Carmen Frida Kahlo Calderón, nacida tal día como hoy de 1907.
#FridaKahlo
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BeijingPalmer
3 months ago
skipping my vacation because chatgpt can simply summarize everywhere I would have visited for me
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MwahahahahahadScientist
12 months ago
Sleep when the baby sleeps, eat when the baby eats, edit your manuscript when the baby edits their manuscript
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Pilar Cacheiro
Mike Inouye
3 months ago
The UK Govt just released its 10 year plan for the NHS and it is legitimately ambitious and exciting. Genomic population health features heavily... on the cover even!
assets.publishing.service.gov.uk/media/686638...
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Carl T. Bergstrom
3 months ago
AI summaries kill search traffic. This has been an obvious consequence of Google's AI summary strategy since its inception. Apparently the training data is so valuable that Google is willing to risk the neck of the goose that lays golden eggs. Screenshot:
thebullshitmachines.com/lesson-9-blu...
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I've been to conference venues with worse views.
3 months ago
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So many chairs. For people to enjoy themselves. For free. It often feels like you always have to spend money to have fun. Not if you are resourceful. The kind of resources that matter.
3 months ago
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3 months ago
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Pilar Cacheiro
Ricard Solé
3 months ago
Why did cephalopods develop intelligence? And why, being so intelligent and cognitively complex, do they die so young? In this
@cp-trendsecolevo.bsky.social
paper, the authors explore this paradox from an ecological and evolutionary perspective.
www.cell.com/action/showP...
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Ceci n'est pas Londres.
3 months ago
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Ardem Patapoutian
3 months ago
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
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The forgotten half of scientific thinking | PNAS
The forgotten half of scientific thinking
https://www.pnas.org/doi/10.1073/pnas.1404649111
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Pilar Cacheiro
Žiga Avsec
3 months ago
Excited to launch our AlphaGenome API
goo.gle/3ZPUeFX
along with the preprint
goo.gle/45AkUyc
describing and evaluating our latest DNA sequence model powering the API. Looking forward to seeing how scientists use it! @googledeepmind
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So much promise in a summer morning.
3 months ago
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For reasons, I ended up reading this day. I would be lying if it said it made my day, because my day was already top top, but it definitely brightned it even more. 'On being the right size'
www.phys.ufl.edu/courses/phy3...
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https://www.phys.ufl.edu/courses/phy3221/spring10/HaldaneRightSize.pdf
3 months ago
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Pilar Cacheiro
Katie Mack
3 months ago
When a chatbot gets something wrong, it’s not because it made an error. It’s because on that roll of the dice, it happened to string together a group of words that, when read by a human, represents something false. But it was working entirely as designed. It was supposed to make a sentence & it did.
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Katie Mack
3 months ago
Chatbots — LLMs — do not know facts and are not designed to be able to accurately answer factual questions. They are designed to find and mimic patterns of words, probabilistically. When they’re “right” it’s because correct things are often written down, so those patterns are frequent. That’s all.
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Pilar Cacheiro
Nonia Pariente
3 months ago
Excellent and thought-provoking. A highly recommended read
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Pilar Cacheiro
Katie Mack
3 months ago
It may be true (I don't know enough neuroscience to say) that LLMs & human brains use similar techniques to make connections between concepts & learn. But most humans don't speak confidently & coherently about something unless they actually know it. The ones who do... well, we have words for them.
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Lucy Fishwife 🥐
3 months ago
A system already exists to over-confidently state incorrect facts to women, thanks, we don’t need another one
add a skeleton here at some point
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Dr. Jens Foell
4 months ago
What is common knowledge in your field, but shocks outsiders? We’re not clear on what intelligence is, at all
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Pilar Cacheiro
European Society of Human Genetics
4 months ago
📢 Episode 4 of the
#eshg
Webinar Series is on June 25 at 16:00 CEST! 🧬 Speaker: Kaitlin Samocha on variant interpretation using population data 💻 Registration is free but mandatory:
wma.eventsair.com/eshg-webinar...
📩 Past registrants will receive the Zoom link automatically.
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Pilar Cacheiro
EMBL-EBI
4 months ago
If EMBL-EBI managed data resources have ever saved you time & effort, this is your chance to give back! Fill in a 15-minute survey to help us: 🌍Demonstrate the real-world impact of our resources 🤓Understand your needs 🌟Secure continued funding Closes 16 July
www.surveymonkey.com/r/QGFMBH8?ch...
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Pilar Cacheiro
Simon Fisher
4 months ago
Your genome is not a blueprint. A thread about misleading metaphors in science communication. 🧬🧪 1/n
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Alex Wild
4 months ago
Happy Father's day as well to all the bug dads. Male water bugs, Belostomatidae, carry their partner's eggs around on their backs until they hatch, making sure the temperature and oxygen levels are acceptable, and the predators are at bay.
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Lizzie Radford. Saturation Genome Editing in SLC2A1. Essentiality screens to assess the impact of VUS.
#CCG2025
4 months ago
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Good science ✔️ New ideas ✔️ Stimulating chats ✔️ A proper summer night ✔️ This is life being gentle to me.
4 months ago
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Veronica Kinsler. Beautiful talk on mosaic disorders.
#CCG2025
4 months ago
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There are worse places to wake up to.
4 months ago
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Steven Harrison on ACMG standards for sequence variant classification.
#CCG2025
4 months ago
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Galicia is a great place to live, and Ceres is a brilliant scientist to work with. It might not look like it, but it is a completely unbiased statement.
add a skeleton here at some point
4 months ago
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