New preprint alert: we use sign errors as a test of how well TWAS works. Very worryingly we find that TWAS gets the sign wrong around 1/3 of the time (compared to 50% for pure guessing). You can read more about our analysis here, and what we think is going on 👇

Allele Frequencies at Recessive Disease Genes are Mainly Determined by Pleiotropic Effects in Heterozygotes https://www.biorxiv.org/content/10.64898/2025.12.05.692665v1

We are thrilled to announce the first official release (v0.1.8) of #𝗯𝗲𝗱𝗱𝗲𝗿, the successor to one of our flagship tool, #𝗯𝗲𝗱𝘁𝗼𝗼𝗹𝘀! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen. 1/n

As promised, a longer thread on what I consider to be some of the most interesting and important contributions of this paper (1/10)

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

Excited to present my poster, “Tissue-Related Heterogeneity in Genetic Architecture of mtDNA Copy Number” (Board 5081), on Wednesday at #ASHG2025 !

Excited to be presenting my poster “Residual Stratification and Increased Genetic Diversity in Multi-ancestry GWAS”, Board 1062T on Thursday, October 16 from 2:30pm-4:30pm at #ASHG2025!

Our paper on the theoretical properties of SNP heritability in admixed populations is out in Genetics: academic.oup.com/genetics/adv... with @jinguohuang.bsky.social, @nicole-kleman.bsky.social , Saonli Basu, and Mark Shriver

An update to our preprint led by @jinguohuang.bsky.social and @nicole-kleman.bsky.social on interpreting SNP heritability in admixed populations, now with HE regression and LD Score regression in addition to GREML.