Preprint online right before the holidays! Excited to share the first piece of work from the Zhang Lab, led by my absolutely stellar postdoc Michelle Kim! In this work, we ask how admixture, selection and demography shape complex trait genetics and GWAS performance www.biorxiv.org/content/10.6...

Work from my amazing undergrad @leyan-wang.bsky.social is just preprinted! TL;DR: If you worry that ARG methods might fail on unphased data due to phasing errors, you may not need to. Check it out & consider reposting to support a great young scientist!

Excited to share work from my postdoc with @docedge.bsky.social and collaborators Matt Pennell and @jgschraiber.bsky.social, newly out over the weekend: www.biorxiv.org/content/10.1... (1/6)

Alessandro and I discussed a paper analyzing a deleterious genetic interaction that causes melanoma in swordtail fishes.

In this #Journal Club, @delvecchyo.bsky.social#Journal&Co discuss a study that mapped the genetic basis of hybrid incompatibility in swordtail fish, revealing #melanoma-causing gene interactions that reduce survival in natural hybrid populations. 📖 ⬇️

Alessandro and I discussed this great paper www.science.org/doi/10.1126/... that investigates a deleterious genetic interaction that causes melanoma.

Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science! This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵). www.science.org/doi/10.1126/...

Gaceta UNAM cubrió nuestra investigación sobre el impacto de la selección natural en la predicción genética de rasgos complejos en individuos del pasado: www.gaceta.unam.mx/la-seleccion...

Hey, Miles' @milesroberts.bsky.social beautiful paper showing that sequence diversity missed by standard methods contributes to Lewontin's paradox is officially published in @evolletters.bsky.social. academic.oup.com/evlett/advan...

Our review of recent Sequentially Markovian Coalescent methods is up on arXiv: arxiv.org/abs/2506.00692 (based on last year's @official-smbe.bsky.social symposium)

Happy to have worked on this project with @mashaals.bsky.social , Emilia Huerta-Sanchez and Valeria Añorve-Garibay. We analyzed how stabilizing and directional selection cause problems to predict traits in ancient samples.

📣Online now! 📄Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples 🧑‍🤝‍🧑 @delvecchyo.bsky.social @mashaals.bsky.social & co

We continue with the #human genetic variation and ancient #genomics session! Our next speaker is @delvecchyo.bsky.social, who is telling us about how to use geographical and temporal information to infer the action of natural #selection @liigh-unam.bsky.social #LIIGH10anniversary

The next talk is by PhD student Alan Izarraras from @delvecchyo.bsky.social's group, and he is telling us about how to infer the distribution of fitness effects using local genealogies @liigh-unam.bsky.social #LIIGH10anniversary

🚨🪅 Registration is NOW OPEN for our Symposium on Ancient Pathogen Genomics! 🦠🧬 Join us on April 12-13 2025 in Juriquilla, Mexico. Featuring top speakers & great science in a beautiful venue! Plz RT ! liigh.unam.mx/apg/ 🪅🚨

New preprint (with @linoafferreira.bsky.social) where we explore the idea of using genealogies (in the form of ancestral recombination graphs, ARGs) to tell apart real GxG interaction signals between nearby variants from false positives www.biorxiv.org/content/10.1...

Don't forget to submit your abstract for "Probabilistic Modeling in Genomics 2025". Deadline: January 10th, 2025. meetings.cshl.edu/meetings.asp...

I have received tenure! I got here thanks to the support from my students, colleagues, mentors and home institution ( @liigh-unam.bsky.social ). I plan to continue doing research on Theoretical Population Genetics and developing methods to understand how Evolution has shaped our past.

Our preprint analyzing the impact of stabilizing and directional selection on the prediction of complex traits in ancient samples is out. Work spearheaded by Valeria Añorve-Garibay in collaboration with Mashaal Sohail and Emilia Huerta-Sánchez. Thread below: www.biorxiv.org/content/10.1...

Happy to see @Alanizarr, Sebastián Iturbe and Abad Guzmán from our group presenting their work during the poster session. #SMBE2024

During dinner a lot of people were asking: "Where is the after party?". It is tomorrow at 9am. We have a great set of talks on new approaches to estimate demography and natural selection. Symposium organized with @valenomics #smbe2024

"Community Engagement Experiences of the Afromexico Genomics Project" by @paleogenomics .

Our group will have a strong presence at #SMBE2024 . Two students will be giving talks and another three students will be presenting posters.

The abstract book is available online along with the scientific program and the travel guide to #smbe2024 #smbe24 https://smbe2024.org/#smbe2024#smbe24 Happy to see the community in Puerto Vallarta, Mexico soon.

Don't forget to register for #SMBE2024 https://smbe2024.org/#SMBE2024today in order to be part of the scientific program if you were accepted to give a poster or oral presentation.

We had a strong presence in the "Días Académicos" event held the last couple of days @LIIGH_UNAM . We had poster presentations by Sebastián Iturbe and Abad Guzmán. @AlanIzarr and @PsyduckResearch gave talks.

Our perspective piece "The Promise of Inferring the Past Using the Ancestral Recombination Graph (ARG)" is out. Work with Débora YC Brandt, Christian D Huber , Charleston WK Chiang: academic.oup.com/gbe/article/...

Our perspective piece "The Promise of Inferring the Past Using the Ancestral Recombination Graph (ARG)" is out. Work with @deboraycb, @christiandhuber and @CharlestonCWKC : https://academic.oup.com/gbe/article/16/2/evae005/7577593

We, Alan Izarraras Gomez and I, wrote a 'News and Views' on the latest Nakatsuka et al. (2023) paper discovering an ancient migration (around 5,200 years old) from Northwest Mexico to California that likely spread a language family in California: www.nature.com/articles/d41... rdcu.be/drLBe

Congratulations to @valenomics on getting her bachelor's degree in Genomic Sciences after defending her thesis today. She has been leading two projects during her senior year in collaboration with @emiliahsc and @mashaals . It is an honor to work with this rising star.

Made a virtual appearance at #SMBEsmallpops to argue that the Ancestral Recombination Graph can be leveraged to make management decisions that preserve our biodiversity. This is work spearheaded by @AlanIzarr and we are currently writing the paper. I'll keep you posted.

Some members of the lab and I found Darth Vader. We also enjoyed a "Millenium Falcon" pizza.

Happy to have joined the editorial board of @GenomeBiolEvol . Thanks to Laura A Katz and @AdamEyreWalker for this kind invitation! https://academic.oup.com/gbe/pages/Editorial_Board

The great @HctorAlessandr will be a PhD student in our group. We are very lucky to have him and look forward to seeing more of his great work.

Congratulations to Earth's version of the Hero of Time, @hctoralessandr , for getting his master's degree by developing a new method to infer how natural selection acts using temporal genetic data. @nintendo decided to release the new Zelda game the same day he got his degree.

Great to see this commentary highlighting the recent paper led by Ryan Buck and Lluvia Flores-Rentería on the Southwestern pinyon pine syngameon. Syngameons are groups of species that form diverse hybrids. Happy to have contributed to this work:...

We had a fantastic seminar from @MaanasaRaghavan @GenSCAPE_Lab on Monday at the @LIIGH_UNAM . Great research involving fair and respectful collaborations with local communities to understand the past human history in South Asia and South-east Asia.

I'll be at #ASHG2022 showing @AlanIzarr 's work on inferring the distribution of fitness effects by leveraging the ancestral recombination graph. I'll also be giving seminars at USC, UCLA, Brown and Penn State in the upcoming weeks.

We had visitors from @UCBerkeley and @INMEGEN this week. @dianaguilr and @andrewhvaughn gave two fantastic seminars. @dianaguilr talked about her work on identifying the genes that determine the pigmentation patterns of a species of frogs in Central America... (1/N)

Débora Brandt, @christiandhuber , @CharlestonCWKC and I are organizing the global virtual symposia "Using Ancestral Recombination Graphs (ARGs) to Infer Evolutionary Processes" on September 30, 2022. Abstract submission and registration are open!...

Congratulations to @AlanIzarr on passing his oral qualifying exam and becoming a PhD candidate. It is an honor to have you in our group. Next month he will do a research stay in @ras_nielsen 's group at Berkeley thanks to the generous support of the UC MEXUS program.

Our paper was highlighted on the April issue of @GeneticsGSA :) https://academic.oup.com/genetics/issue/220/4

We had a great couple of seminars in the last few days @Liigh . Debora Brandt talked about her recent paper evaluating methods that do ARG reconstruction ( https://www.biorxiv.org/content/10.1101/2021.11.15.468686v3 ). @benmpeter discussed his latest work on the past history and...

Our paper presenting a new methodology that leverages linkage disequilibrium patterns to infer the distribution of fitness effects of standing genetic variants as well as new mutations is up on @GeneticsGSA . Many improvements since the BioRxiv...

Happy to share this review written with @mashaals and @AlanIzarr . We discuss how genetic, biogeographical and sociocultural factors act jointly to shape the spatial variation of complex traits. https://doi.org/10.1093/gbe/evab272 (1/9).

Today we had a great virtual seminar at the @LIIGH_UNAM by @christiandhuber on how admixture complicates the detection of past hard sweeps in humans. Part of this work can be found on Christian's latest updated preprint: https://www.biorxiv.org/content/10.1101/2020.04.01.021006v2

This is an amazing review by Evan M. Koch and Shamil R. Sunyaev that analyses how natural selection shapes patterns of genetic and phenotypic variation....

I admire the courage of the four women scientists that denounce how one PI at a major research institution in Mexico, @Langebio, sexually harassed them. (1/2) https://www.science.org/content/article/women-accuse-famed-plant-geneticist-sexual-harassment

We had the honor of hosting a virtual seminar by @Johri_Parul in the @LIIGH_UNAM . Super cool work on new methods to perform joint inference of demography and the impact of purifying selection. Thank you for sharing your work with us!