Lino Ferreira
@linoafferreira.bsky.social
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📥 533
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Researcher in statistical genetics looking for new professional opportunities PhD from Oxford lfe.pt
reposted by
Lino Ferreira
Molly Przeworski
13 days ago
Happy to highlight an essay I wrote together with
@marcdemanuel.bsky.social
,
@natanaels.bsky.social
and Anastasia Stolyarova, trying to think through what sets the mutation rate of a cell type in an animal species:
www.biorxiv.org/content/10.6...
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What sets the mutation rate of a cell type in an animal species?
Germline mutation rates per generation are strikingly similar across animals, despite vast differences in life histories. Analogously, in at least one somatic cell type, mutation rates at the end of l...
https://www.biorxiv.org/content/10.64898/2025.12.19.695482v1
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Lino Ferreira
Jonathan Pritchard
24 days ago
GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday:
www.nature.com/articles/s41...
A short🧵:
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Causal modelling of gene effects from regulators to programs to traits - Nature
Approaches combining genetic association and Perturb-seq data that link genetic variants to functional programs to traits are described.
https://www.nature.com/articles/s41586-025-09866-3
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Lino Ferreira
Ana Ignatieva
3 months ago
Delighted that our paper about the distribution of genomic spans of clades/edges in genealogies (ARGs), and using this for detecting inversions and other SVs (and other phenomena that cause local disruption of recombination) is out in MBE
academic.oup.com/mbe/article/...
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The Length of Haplotype Blocks and Signals of Structural Variation in Reconstructed Genealogies
Abstract. Recent breakthroughs have enabled the accurate inference of large-scale genealogies. Through modelling the impact of recombination on the correla
https://academic.oup.com/mbe/article/42/9/msaf190/8223473
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Lino Ferreira
bioRxiv Bioinfo
about 1 month ago
SuSiE 2.0: improved methods and implementations for genetic fine-mapping and phenotype prediction
https://www.biorxiv.org/content/10.1101/2025.11.25.690514v1
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Lino Ferreira
Yang Luo
about 1 month ago
🚨 New preprint from the lab! We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al.
www.medrxiv.org/content/10.1...
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Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵
www.medrxiv.org/content/10.1...
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Interactions with polygenic background impact quantitative traits in the UK Biobank
Association studies have linked many genetic variants to a variety of phenotypes but under-standing the biological mechanisms underlying these signals remains a major challenge. Since genes operate wi...
https://www.medrxiv.org/content/10.1101/2025.11.14.25340263v1
about 1 month ago
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Lino Ferreira
Genetics Society of America
3 months ago
New study in
#GENETICS
from
@anaignatieva.bsky.social
and
@linoafferreira.bsky.social
shows how ancestral recombination graphs can help detect "phantom" genetic interaction signals that arise due to genealogy and not because of epistasis.
buff.ly/TQARoDp
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Lino Ferreira
Ana Ignatieva
4 months ago
Our paper about how ancestral recombination graphs can be used to detect "phantom" genetic interaction signals (that arise due to the genealogy, rather than "real" epistasis) is out in Genetics! Nice thread here by
@linoafferreira.bsky.social
academic.oup.com/genetics/adv...
add a skeleton here at some point
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Delighted to see this paper with
@anaignatieva.bsky.social
now published in Genetics!
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
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Phantom epistasis through the lens of genealogies
Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef
https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyaf184/8248594
4 months ago
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Excited to have this out there! Comments are very welcome.
add a skeleton here at some point
about 1 year ago
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Lino Ferreira
Marc de Manuel
about 1 year ago
📣 Two ERC-funded positions are available in the lab! If you are interested in exploring the mechanisms underlying mutation, we’d love to hear from you. PhD:
shorturl.at/Oc04N
Postdoc:
shorturl.at/1ShHB
RPs and shares would be greatly appreciated! 🧪🧬🖥️
#ScienceJobs
#PostdocJobs
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Lino Ferreira
Anjali Hinch
over 1 year ago
The Hinch lab is looking for an enthusiastic statistician, mathematician or physicist to join us as a post doc! If you'd like to use big data to decode the inner workings of our cells, apply now:
germlinegenomics.web.ox.ac.uk
Please re-post and thanks!
#PhDjobs
#Postdocs
#STEM
#meiosis
#genomics
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Lino Ferreira
Graham Coop
over 1 year ago
Congratulations to Carl Veller on the publication of his article on confounding in population and family GWAS
journals.plos.org/plosbiology/...
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Interpreting population- and family-based genome-wide association studies in the presence of confounding
GWASs aim to estimate direct effects of genotype on an individual’s phenotype, but this can be subject to genetic and environmental confounds and
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002511
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My PhD programme, the 'DPhil in Genomic Medicine and Statistics' at the Wellcome Centre for Human Genetics in Oxford, is accepting applications for next year! I'm coming to the end of my studies after four years and feel so fortunate to have been part of it. Students get...
about 2 years ago
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First post on this celestial platform to mark a happy occasion: I've submitted my PhD thesis! I've celebrated and rested well and am now back to working on research after all the writing... Excited for what's to come!
about 2 years ago
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