We are recruiting two biomedical data scientists as part of a new Centre of Research Excellence (MRC CoRE) in Exposome Immunology hosted jointly by @fbmh-uom.bsky.social and @ox.ac.uk. www.jobs.manchester.ac.uk/Job/JobDetai... www.jobs.manchester.ac.uk/Job/JobDetai...

WE ARE HIRING! www.manchester.ac.uk/exposome-jobs Vacancies inc. 3x PDRA positions, 2x data scientists and a Transition Fellowship in Air Pollution. Join us as we embark on a 14 year journey to understand how the exposome impacts immune regulation and chronic inflammation. #hiring #immunosky

On Monday 8 September, Dr Jonathan Marchini will present 'Using human genetics at scale to power drug discovery'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/c42...

Thinking of applying for a PhD (DPhil) with us? Join our DPhil Open Day to meet our group leaders and chat with other students! 🗓️ Friday 24 October ⏰ 1 – 5pm 📍 Kennedy Institute Find out more and register for your place 👉https://www.kennedy.ox.ac.uk/study-with-us/open-day

This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠 🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

A truly amazing and inspiring PI to work with!

Summer outing for the team — feeling very fortunate to work with such talented and wonderful people.

📣First paper from the lab is out in @science.org‬! 📣https://www.science.org/doi/10.1126/sciadv.adu3461 It’s well known that HLA shapes the TCR repertoire — but how does this change under immune checkpoint blockade (ICB)?

We're hiring a skilled Research Assistant to process and inventory samples from clinical studies looking at inflammatory diseases, including Rheumatoid Arthritis and Inflammatory Bowel Disease. Apply by 6 August! www.kennedy.ox.ac.uk/jobs/researc...

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases. #Exposome #ImmunoSky sites.manchester.ac.uk/lydia-becker...

Amazing news! Excited to be part of this new direction of research.

Sarah, a talented master student in the group, is presenting her (4-week-long) work on multi-ancestry HLA-pQTLs at Human Proteome and Health meeting today @ox.ac.uk! 🥳

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford. More info here: bit.ly/biomedDPhil 🗓️ App deadline: June 30th 2025. Please share!

Proud supervisor moment - well done Jennie! @kennedydatascience.bsky.social

📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST. Sign up: www.lyyti.fi/reg/aging_we...

Ciao #eshg2025! We had a good time!

Slides are here: www.mendelianrandomization.com/images/burge.... If you are interested in learning more, we have online courses on Mendelian randomization and Genetics in Drug Development (www.mendelianrandomization.com/index.php/on...) with continuous enrolment: please sign up!

@stevesphd.bsky.social is speaking on MR now at #eshg2025. “People run MR analyses without understanding the science — treating it like a psychic power,” warns the guru. A timely reminder: method ≠ magic. #MR #Genetics

So excited to give a talk at #ESHG2025! ✨ I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants. This has implications for: - Screening of rare disorders 🔎 - Target discovery 💊 - Improving trait prediction 📈

Krista kicks off the MR talk at #eshg2025 in Milan with the perfect example — #coffee vs mortality. Shocking figure - Looks like my 4 cups a day might actually be doing me good! ☕💪

Krista and I are giving an introduction to Mendelian randomization in Brown 3 starting in a few moments - I will post my slides here after the session #eshg2025

Claringbould delivers a beautiful method #eshg2025 📣SUM-seq📣 for co-assaying chromatin accessibility and gene expression in single nuclei (www.biorxiv.org/content/10.1... appearing *soon*). Integrating with 4700 variants from 14 GWAS further pinpointed the impact of specific TFs on immune diseases.

@kauralasoo.bsky.social starts his plenary talk #eshg2025 with their heroic effort of integrating eQTL studies (eQTL Catalogue, v7 42 studies, www.ebi.ac.uk/eqtl/Data_ac...). From personal experiences, this is an amazing resource!

Mostafavi kicks off 8.30am session #eshg2025 with a brilliant talk - he showed clearly how burden tests prioritise trait-specific genes and GWAS priortise trait-specific variants ==> potential different biology. context-specific eQTLs may help address gaps, but it might be biased.

Pirruccello #eshg2025 - “There is really one game in town right now that is @ukb UKB.” - no one else is producing image data in healthy heart at this scale. @ukbiobank.bsky.social Taking a deep-dive into image-derived phenotypes such as sphericity and cardiac age acceleration.

Cai shows beautifully the power of “deep-phenotype imputation” in major depressive disorder (MDD) #eshg2025. Improved power in variant discovery and PRS prediction. paper:https://www.nature.com/articles/s41588-023-01558-w

amazing effort of deriving latent phenotypes based on imaging data (cardiac MRI) using UKB from Glastonbury #eshg2025. From multi-trait colcoalisation with GWAS cardiometabolic traits, they found novel variants that associated with disease endpoints. Next scaling up to other organ in UKB!

You can map between gene expression and morphology using [?magic? See preprint]. Cell morphology captures heritability a bit less well than GXP, but you see some orthogonal heritable components eg for ADHD. www.biorxiv.org/content/10.1...

We are #eshg2025! Here's where you can find us.

Amazing population-level single cell RNAseq showcases at #eshg2025 -TenK10K (Powell, Australia) and 6.5K donors (Soranzo,UK). lots of interesting findings:cell-type specific eQTLs, disease-associated cell compositions, eGenes enrichment for drug developments, etc. Crucially - they're *open source*!

It's great to be in a beautify conference centre without starbucks #eshg2025

Great poster sessions today #BSI Oxford 2025

Jennie is giving a brilliant seminar summarising her DPhil work on context- and cell type-specific single cell eQTLs so far #proudPImoment

Amazing line up from the lab this morning @bdi to talk about HLA-TCR interaction at both bulk and single cell level

Yearly lab updates: 1️⃣ Two brilliant postdocs joined the team! 2️⃣ Our first preprint is out (www.biorxiv.org/content/10.1...) stay tuned! 📄 3️⃣ a newly awarded WT Early Career Fellow 4️⃣ UK International Student Excellence Award (x.com/Ruthnanje/st...) Felling blessed with an amazing team! 🙌😊

📣Happy to share my first bluesky post with a new publication!https://www.nature.com/articles/s41467-024-54741-w?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20241129&utm_content=10.1038/s41467-024-54741-w