On Monday 9 February, Professor Philip Awadalla will join us to present 'Integrating Cohorts and Multi-Omics to Capture the Earliest Determinants of Disease and Aging'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/19a...

We have a webinar next week with @ukbiobank.bsky.social on the Nightingale metabolomics data. We did a table read today, and it is shaping up really nicely. Please do come! 300 people have registered already and there are only np.inf spaces left! www.ukbiobank.ac.uk/use-our-data...

Great round of talks from the team at the SMARTbiomed Symposium at Oxford today.

Hiring: Group Leader in Microbiome Studies! ✨ The successful candidate would establish & lead a new research group in human microbiome science, advancing understanding of microbe-microbe and microbe-host interactions in health & disease. Apply by 22 Dec. www.ndorms.ox.ac.uk/jobs/kennedy...

annual Xmas dinner - blessed with a wonderful team🥰

📣📣📣 Excited for our lab's latest preprint, led by Chief Ben-Eghan! www.medrxiv.org/content/10.1... tl;dr We identify protein vQTLs in multiple ancestries then use MVMR to show independent effects of mean & variance on disease, suggesting targeting protein variance could have therapeutic potential.

We have a new open position to analyze large-scale genomic datasets and EHR data to better understand and improve care for type 2 diabetes and monogenic diabetes, in collaboration with Chirag Patel, Miriam Udler, Aaron Leong, and many others. Please share! broadinstitute.avature.net/en_US/career...

Improving population-scale disease prediction through multi-omics integration https://www.medrxiv.org/content/10.1101/2025.11.24.25340920v1

🚨 New preprint from the lab! We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

Amazing work! Congrats @linoafferreira.bsky.social !

Excited to share a preprint of my PhD project looking at interactions between SNPs and polygenic scores in the UK Biobank! A thread... 🧵 www.medrxiv.org/content/10.1...

Some talks are good, some are exciting, and some are truly inspirational. This is one of them — “Smarter trials for better health” by Sir Martin Landray. @martinlandray.bsky.social

✨ It was a real pleasure to host @mikeinouye.bsky.social today! A fantastic seminar connecting polygenic scores with multi-omic profiles — showing how integration can power next-generation disease prediction. #systemgenomics

One more week to go! Come and join us for this exciting Exposome journey.

We are #hiring a postdoc as part of the new MRC CoRE in Exposome Immunology! The role will systematically explore the impact of the exposome on complex disease risk, through the lens of multi-omics data. Apply by 5 Nov 👇 www.kennedy.ox.ac.uk/jobs/postdoc...

Excited to be working with this amazing group!

We’re delighted to hear that our favourite cell type (Regulatory T cells!) have been recognised in the Nobel Prize this year! Huge congratulations to Mary, Fred, and Shimon for their pivotal work in the field & here’s to many exciting Treg advances to come!🥳👏🎉

🌟 Postdoc Opportunity – MRC CoRE in Exposome Immunology 🌟 Join us to explore how the exposome shapes complex disease risk using multi-omics & global biobank data. @kiroxford.bsky.social , @exposomeimmunology.bsky.social ✅ Apply: lnkd.in/gJHJDvKn 🗓️ Deadline: 12pm, 30 Oct 2025

@soumya-boston.bsky.social when are you coming ? ;-)

Great to host Fan at Kennedy - explainable AI model in single cell!

We are recruiting two biomedical data scientists as part of a new Centre of Research Excellence (MRC CoRE) in Exposome Immunology hosted jointly by @fbmh-uom.bsky.social and @ox.ac.uk. www.jobs.manchester.ac.uk/Job/JobDetai... www.jobs.manchester.ac.uk/Job/JobDetai...

WE ARE HIRING! www.manchester.ac.uk/exposome-jobs Vacancies inc. 3x PDRA positions, 2x data scientists and a Transition Fellowship in Air Pollution. Join us as we embark on a 14 year journey to understand how the exposome impacts immune regulation and chronic inflammation. #hiring #immunosky

On Monday 8 September, Dr Jonathan Marchini will present 'Using human genetics at scale to power drug discovery'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/c42...

Thinking of applying for a PhD (DPhil) with us? Join our DPhil Open Day to meet our group leaders and chat with other students! 🗓️ Friday 24 October ⏰ 1 – 5pm 📍 Kennedy Institute Find out more and register for your place 👉https://www.kennedy.ox.ac.uk/study-with-us/open-day

This project is in close collaboration with the amazing @lukejostins.bsky.social, and the student will benefit from a multi-disciplinary team! 🌟🧬🧠

🎓 New PhD opportunity in our lab @kiroxford.bsky.social @oxforduni.bsky.social We're exploring host–microbiome genetic interactions in IBD using population-scale data 🧬🦠 🔗 kennedy.ox.ac.uk/.../deciphering-host2013microbiome-genetic-interactions-in-inflammatory-bowel-disease #PhD #Genetics

A truly amazing and inspiring PI to work with!

Summer outing for the team — feeling very fortunate to work with such talented and wonderful people.

📣First paper from the lab is out in @science.org‬! 📣https://www.science.org/doi/10.1126/sciadv.adu3461 It’s well known that HLA shapes the TCR repertoire — but how does this change under immune checkpoint blockade (ICB)?

We're hiring a skilled Research Assistant to process and inventory samples from clinical studies looking at inflammatory diseases, including Rheumatoid Arthritis and Inflammatory Bowel Disease. Apply by 6 August! www.kennedy.ox.ac.uk/jobs/researc...

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases. #Exposome #ImmunoSky sites.manchester.ac.uk/lydia-becker...

Amazing news! Excited to be part of this new direction of research.

Sarah, a talented master student in the group, is presenting her (4-week-long) work on multi-ancestry HLA-pQTLs at Human Proteome and Health meeting today @ox.ac.uk! 🥳

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣 Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...

Come join us! We have an exciting PhD opportunity in statistical genetics at the University of Oxford. More info here: bit.ly/biomedDPhil 🗓️ App deadline: June 30th 2025. Please share!

Proud supervisor moment - well done Jennie! @kennedydatascience.bsky.social

📣 Our webinar “Measuring the effects of aging with metabolomic profiling” by @lukejostins.bsky.social is tomorrow! Remember to sign up and join us tomorrow at 3 p.m. CEST. Sign up: www.lyyti.fi/reg/aging_we...

Ciao #eshg2025! We had a good time!

Slides are here: www.mendelianrandomization.com/images/burge.... If you are interested in learning more, we have online courses on Mendelian randomization and Genetics in Drug Development (www.mendelianrandomization.com/index.php/on...) with continuous enrolment: please sign up!

@stevesphd.bsky.social is speaking on MR now at #eshg2025. “People run MR analyses without understanding the science — treating it like a psychic power,” warns the guru. A timely reminder: method ≠ magic. #MR #Genetics

So excited to give a talk at #ESHG2025! ✨ I presented our work demonstrating that individuals whose phenotype deviates from genetic expectation are enriched for rare damaging variants. This has implications for: - Screening of rare disorders 🔎 - Target discovery 💊 - Improving trait prediction 📈

Krista kicks off the MR talk at #eshg2025 in Milan with the perfect example — #coffee vs mortality. Shocking figure - Looks like my 4 cups a day might actually be doing me good! ☕💪

Krista and I are giving an introduction to Mendelian randomization in Brown 3 starting in a few moments - I will post my slides here after the session #eshg2025

Claringbould delivers a beautiful method #eshg2025 📣SUM-seq📣 for co-assaying chromatin accessibility and gene expression in single nuclei (www.biorxiv.org/content/10.1... appearing *soon*). Integrating with 4700 variants from 14 GWAS further pinpointed the impact of specific TFs on immune diseases.

@kauralasoo.bsky.social starts his plenary talk #eshg2025 with their heroic effort of integrating eQTL studies (eQTL Catalogue, v7 42 studies, www.ebi.ac.uk/eqtl/Data_ac...). From personal experiences, this is an amazing resource!

Mostafavi kicks off 8.30am session #eshg2025 with a brilliant talk - he showed clearly how burden tests prioritise trait-specific genes and GWAS priortise trait-specific variants ==> potential different biology. context-specific eQTLs may help address gaps, but it might be biased.

Pirruccello #eshg2025 - “There is really one game in town right now that is @ukb UKB.” - no one else is producing image data in healthy heart at this scale. @ukbiobank.bsky.social Taking a deep-dive into image-derived phenotypes such as sphericity and cardiac age acceleration.

Cai shows beautifully the power of “deep-phenotype imputation” in major depressive disorder (MDD) #eshg2025. Improved power in variant discovery and PRS prediction. paper:https://www.nature.com/articles/s41588-023-01558-w

amazing effort of deriving latent phenotypes based on imaging data (cardiac MRI) using UKB from Glastonbury #eshg2025. From multi-trait colcoalisation with GWAS cardiometabolic traits, they found novel variants that associated with disease endpoints. Next scaling up to other organ in UKB!

You can map between gene expression and morphology using [?magic? See preprint]. Cell morphology captures heritability a bit less well than GXP, but you see some orthogonal heritable components eg for ADHD. www.biorxiv.org/content/10.1...