Meiosis faces a fundamental problem: It must repair hundreds of DNA double-strand breaks while executing a transcriptional programme essential for gamete development. But many of these breaks occur in genes. So how are these two processes reconciled? www.biorxiv.org/content/10.6...

Yet another outstanding recruit to @dunnschool.bsky.social! Really looking forward to having Alex Borodavka as a new colleague

Congratulations to the Dunn School postdocs starting their independent research groups across the UK, Germany and China 🥳 - Iqbal Dulloo (@iqbaldulloo.bsky.social) - Marion Schuller (@schullerm.bsky.social) - Yongxu Lu - João Monteiro www.path.ox.ac.uk/news-article...

A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]

Emily passed her transfer viva with flying colours! Thanks to her awesome examiners Simon Myers and Nicky Whiffin #ProudPI

🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open. We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting. 🗓️ Deadline: October 15th More information: smbe2026.org/symposia #SMBE2026

In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social ‬ & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...

Another exciting opportunity @dunnschool.bsky.social ! Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health Please help us find great applicants

Our PhD studentship programme is officially open; pass it on If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details... Great science and a great environment! www.path.ox.ac.uk/news-article...

Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics! academic.oup.com/genetics/adv... We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵

SINGER, our ARG inference method, is finally published and freely available online: doi.org/10.1038/s415... It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...

New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...

📣 Applications now open 📣 We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease! Please share! www.path.ox.ac.uk/work-with-us...

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...

A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social www.jobs.cam.ac.uk/job/51488/

Wonderful talk by Yun today on the present and future of protein and DNA large language models. Spectacular!

Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social www.ft.com/content/25dd...

Delighted to announce that Prof. Kevin Foster has been elected Fellow of @royalsociety.org! This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities Many congratulations Kevin! Find out more: www.path.ox.ac.uk/news-article...

Amidst all the terrible and terrifying news, so lovely to hear of @jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!

Nature research paper: Towards multimodal foundation models in molecular cell biology https://go.nature.com/3YvGcbJ

Tonight at 5.30pm on the BBC! 📺 The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠 www.path.ox.ac.uk/news-article...

Come work with me! Great opportunity for an enthusiastic Comms or events professional!

What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX

New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social! How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair! Read more 👉 https://doi.org/10.1101/2025.02.10 Follow along for key insights! 🧵

Why do different DNA molecules occupy different places in the nucleus? What drives chromatin compartmentalisation? Read this amazing paper to find out www.science.org/doi/10.1126/... Many congratulations to all the authors of this brilliant work! @rkoszul.bsky.social

This is a great opportunity for someone interested in comms, event planning, science history, or just working @dunnschool.bsky.social in Oxford.

We are deeply sadden by the sudden loss of Scott. He was an astounding mentor and brought so much to the community on top of his excellent science. His legacy will live on #Meiosis4ever

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease? I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

My bluesky debut! One week to the submission deadline for SMBE 2025, Beijing 20-24 July smbe2025.scimeeting.cn @anaignatieva.bsky.social and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.

My book, An Intuitive Primer on Effective Functional Genomics Study Design, is published! I’d really appreciate it if you could help spread the word, and I’d love to hear your thoughts and feedback. I hope people will find it useful. It’s available on Amazon: tinyurl.com/mx2hewen

We just can't stop recruiting! Associate professor in cell and molecular biology @dunnschool, with a preference for immunology, inflammation and/or infection - all defined broadly Come and be our colleague Deadline 28 Feb, please spread the word www.path.ox.ac.uk/vacancy/asso...

Building on our discovery of #LesionSegregation, @mikespencerchapman.bsky.social and colleagues from @sangerinstitute.bsky.social find that some DNA lesions can persist in humans for months or years! "Prolonged persistence of mutagenic DNA lesions in somatic cells" www.nature.com/articles/s41...

A new paper by @tcell.bsky.social and team makes important advances towards improving CAR-T technology! Read the paper here: www.biorxiv.org/content/10.1... Listen to Omer talking about the paper and his spin-out company MatchBio here: podcasts.ox.ac.uk/series/immun...

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland. Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

As promised, season's greetings from all of us @dunnschool.bsky.social (and if your building has a rotunda, flaunt it at Christmas)

Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos

Hi, can anyone point me to the start-of-the-art crossover and/or non-crossover maps for S. cerevisiae. Many thanks!

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. www.nature.com/articles/s41...

Welcome to Bluesky, friends and colleagues from population genetics and meiosis. Great to see you all here!

A wonderful innovation from an old friend!

We have 2 Florence Nightingale Bicentenary Fellow positions now open for applications! 🏢 ID: 176627 📍 Dept. of Stats 📃 Contract: FT, 3yrs 💷 Salary Range: £48.2K - £57.2K/yr ⏲️ Deadline: 06.01.25 12pm UK 💼 Interview: 27.01.2025  🔗 URL: my.corehr.com/pls/uoxrecru...

We are recruiting! 2 computational biology positions are available in the group of Monika Gullerova, to advance RAIDEN, an AI-powered platform transforming RNA-drug discovery! Deadline is the 13th of December Find out more: www.path.ox.ac.uk/work-with-us...

Exciting News: We are thrilled to announce that Prof Gil McVean is the next President of the Genetics Society! A fantastic leader in genetics and data science, he will guide the society into an inspiring new chapter with the incorporation of the Society. genetics.org.uk/22-november-...

Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva meetings.embo.org/event/25-mei...

Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.

I did my 2nd postdoc at the Dunn School and it was the most productive period of my ECR career (with ongoing collaborations even years after I left). I felt very supported scientifically and was encouraged to find/develop a research niche that has become my career as an independent scientist.

Come and do your PhD with us! If you want to investigate the cellular and molecular mechanisms underlying disease in a friendly, supportive community, we want to hear from you! 4 years, fully funded. Applications now open! www.path.ox.ac.uk/study-with-u...

The Dunn school is an absolutely brilliant and supportive scientific community (I couldn't be happier here!). Please reach out if you'd like to learn more!