Leo Speidel
@leospeidel.bsky.social
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📥 158
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Statistical and Population Genetics | RIKEN, iTHEMS (Japan) | 🇯🇵🇩🇪🇬🇧 |
reposted by
Leo Speidel
Aylwyn Scally
14 days ago
Postdoctoral job announcement: come to Cambridge and work on population genetic modelling with environmental and ancient DNA, jointly with
@gamzeandgursoy.bsky.social
and me. Details at
www.jobs.cam.ac.uk/job/55580/
- applications by June 16th.
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Research Associate in Population Genetics Modelling and Environmental DNA (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate in Population Genetics Modelling and Environmental DNA (Fixed Term) in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/55580/
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Leo Speidel
Luane Landau
about 1 month ago
1/ New paper out in Nature Communications! We studied the salivary amylase gene, AMY1, in Indigenous Andean populations and found evidence that high AMY1 copy number rapidly increased in frequency, likely through recent positive selection.
doi.org/10.1038/s414...
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Rapid adaptive increase of amylase gene copy number in Indigenous Andeans - Nature Communications
The salivary amylase gene exhibits copy-number variation linked to dietary shifts. Here, the authors describe an adaptive expansion of the amylase gene in Indigenous Andean populations coinciding with...
https://doi.org/10.1038/s41467-026-71450-8
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Leo Speidel
Marina Silva
about 1 month ago
Our preprint is now out, looking at genomic history and selection in Britain, with a focus on the Roman and early medieval periods. Comments welcome!
www.biorxiv.org/content/10.6...
@boothicus.bsky.social
@leospeidel.bsky.social
@pontus-skoglund.bsky.social
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https://www.biorxiv.org/content/10.64898/2026.04.28.721361v1
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Leo Speidel
Tom Booth
about 1 month ago
🏺🧪Preprint of 1039(!) whole ancient human genomes from Britain, mainly dating to 1st Millennium CE, representing the best part of 7 years of my life. Herculean effort by
@marinasdsilva.bsky.social
to get this over the line. 'Migration Period' is more migrationy than we could have possibly imagined.
add a skeleton here at some point
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New preprint led by Hrushikesh Loya, me, and Simon Myers where we introduce GhostBuster!
www.biorxiv.org/content/10.6...
The idea is to find all the different ways a target individual relates to reference groups in genealogies, to "bust the ghosts" in our ancestry.
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https://www.biorxiv.org/content/10.64898/2026.04.17.719197v1
about 2 months ago
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Very honoured and I owe a lot to all my mentors and colleagues, thank you!
add a skeleton here at some point
about 2 months ago
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New ad for an independent postdoc in mathematics/statistics/machine learning for Biology in my institute at RIKEN (not my lab), ranging from 3 to 7 years. Our institute is entirely English-run, and a good mix of expertise on maths/physics/stats/bio!
www.riken.jp/en/careers/r...
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Seeking a few Senior Research Scientists, Research Scientists, Postdoctoral Researchers at Division of Fundamental Mathematical Science, RIKEN Center for Interdisciplinary Theoretical and Mathematical...
https://www.riken.jp/en/careers/researchers/20251017_1/index.html
8 months ago
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Postdoc position in my group in Tokyo! Please get in touch if you are interested. And happy to discuss projects - these would range from developing new methods to analysis of new genomes that we are now sequencing in the lab. Job Ad:
www.riken.jp/en/careers/r...
Lab page:
speidellab.github.io
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Seeking a few Postdoctoral Researchers at Mathematical Genomics RIKEN ECL Research Unit (25-695)
https://www.riken.jp/en/careers/researchers/20250620_1/index.html
12 months ago
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reposted by
Leo Speidel
Anders Bergström
12 months ago
A 4-year postdoc position in population genomics is available in my group at the University of East Anglia, to work on a project sequencing a thousand fox genomes across rural and urban environments in the UK.
vacancies.uea.ac.uk/vacancies/15...
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Senior Research Associate in Population Genomics (RA2327) in University of East Anglia | UEA
View details and apply for this Senior Research Associate in Population Genomics (RA2327) vacancy in University of East Anglia. Faculty of Science School of Biological Sciences Senior Research A...
https://vacancies.uea.ac.uk/vacancies/1593/senior-research-associate-in-population-genomics-ra2327.html
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reposted by
Leo Speidel
Arun Durvasula
about 1 year ago
Our review of recent Sequentially Markovian Coalescent methods is up on arXiv:
arxiv.org/abs/2506.00692
(based on last year's
@official-smbe.bsky.social
symposium)
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Not Just $N_e$ $N_e$-more: New Applications for SMC from Ecology to Phylogenies
Genomes contain the mutational footprint of an organism's evolutionary history, shaped by diverse forces including ecological factors, selective pressures, and life history traits. The sequentially Ma...
https://arxiv.org/abs/2506.00692
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Leo Speidel
HAAM-community
about 1 year ago
🧵1/n ✨🔮✨ Meet (y)our instructors of this year's
#HAAMsummerschool
👇
#aDNA
#course
#humanpopgen
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Leo Speidel
Jonathan Pritchard
about 1 year ago
I have an opportunity to hire a staff scientist for my lab. Looking for someone with outstanding skillset in ML/statistics, genomics applications; interest in mentoring, strong publication record, PD experience required. Email CV to me+cc my assistant (see 'contact' on my website). Ad to follow.
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Leo Speidel
Lucy van Dorp
about 1 year ago
Our
@ucl.ac.uk
@crick.ac.uk
work, out this week in
@science.org
, traces a genetic time series of bacterial infections to reveal when and how Borrelia recurrentis jumped from ticks to humans—via our body lice.
www.science.org/doi/10.1126/...
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Ancient Borrelia genomes document the evolutionary history of louse-borne relapsing fever
Several bacterial pathogens have transitioned from tick-borne to louse-borne transmission, which often involves genome reduction and increasing virulence. However, the timing of such transitions remai...
https://www.science.org/doi/10.1126/science.adr2147
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reposted by
Leo Speidel
Tábita Hünemeier
about 1 year ago
Our new paper is out in
@science.org
! By exploring the rich genetic diversity of Brazil, we show how fine-scale genomic analyses reveal that this diversity, rooted in Indigenous ancestry and centuries of complex demographic history, plays a key role in population health.
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reposted by
Leo Speidel
Aylwyn Scally
about 1 year ago
Our paper on ancient human population structure is now published. We find that the ancestors of modern humans lived in multiple populations during the period when Homo sapiens evolved in Africa.
www.nature.com/articles/s41...
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A structured coalescent model reveals deep ancestral structure shared by all modern humans - Nature Genetics
The cobraa model extends the pairwise sequentially Markovian coalescent to identify structured population history by examination of the model transition matrix. Applied to human polymorphism data, cob...
https://www.nature.com/articles/s41588-025-02117-1
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reposted by
Leo Speidel
Aylwyn Scally
over 1 year ago
We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here.
www.jobs.cam.ac.uk/job/50414/
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Assistant/Associate Professor in Computational Biology - Job Opportunities - University of Cambridge
Assistant/Associate Professor in Computational Biology in the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge.
https://www.jobs.cam.ac.uk/job/50414/
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Leo Speidel
Matthew Hahn
over 1 year ago
Octo-squid-nautiloid sex chromosomes!
www.sciencedirect.com/science/arti...
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Cephalopod sex determination and its ancient evolutionary origin
Octopuses, squids, and cuttlefishes—the coleoid cephalopods—are a remarkable branch in the tree of life whose members exhibit a repertoire of sophisti…
https://www.sciencedirect.com/science/article/pii/S0960982225000053
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reposted by
Leo Speidel
Kevin Daly
over 1 year ago
Thread and open access version to come- Ancient genomics and the origin, dispersal, and development of domestic sheep | Science
search.app/gtSKYHF5HqRa...
#adna
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Ancient genomics and the origin, dispersal, and development of domestic sheep
The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this, we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Ge...
https://search.app/gtSKYHF5HqRarFCC6
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reposted by
Leo Speidel
Jonathan Pritchard
over 1 year ago
I posted a couple days ago about our new paper on building causal graphs from genetic associations + Perturb-seq. Here I want to expand on the value of using DIRECTIONAL information contained in LoF burden tests.🧵 [work led by
@minetoota.bsky.social
]
bsky.app/profile/jkpr...
add a skeleton here at some point
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reposted by
Leo Speidel
Society for Molecular Biology and Evolution
over 1 year ago
📢📢📢
#SMBE2025
Abstract Submission EXTENDED to Saturday, February 15, 2025 We also invite you to register at
www.smbe2025.org
@SMBEmeetings
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reposted by
Leo Speidel
over 1 year ago
Excited to share our preprint "A putative ecocline in Klebsiella pneumoniae" and super-interested to get your feedback. Really want to use the hive mind to get to the bottom of this phenomenon ASAP.
www.biorxiv.org/content/10.1...
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A putative ecocline in Klebsiella pneumoniae
Are quantitative traits important for bacteriology? The quantitative trait models used in animal and plant genetics assume that the trait takes continuous values and is influenced by many variants cir...
https://www.biorxiv.org/content/10.1101/2025.01.20.633859v2
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My bluesky debut! One week to the submission deadline for SMBE 2025, Beijing 20-24 July
smbe2025.scimeeting.cn
@anaignatieva.bsky.social
and I are organising a symposium on popgen through time: using ARGs, aDNA, or otherwise to understand the evolutionary processes that shape genomes through time.
over 1 year ago
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