The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs: probgen2026.github.io Please help spread the news.

Excited for our publication on how the geographic scale of a sample affects the discovery of rare, deleterious variants to be out this week. With a mix of theory, simulation, and data analysis, we show when samples are narrow vs broad, the number of variants discovered and their frequencies change

New work by Andy Dahl and Michal Sadowski on using GxE to study genetics of drug response now out in Cell Genomics www.cell.com/cell-genomic...

Check it out - PhD student @maggiesteiner.bsky.social's nice thread and link to our new preprint on how sample design, in terms of how geographically narrow vs broad a sample is, impacts the discovery/SFS of deleterious variants.

#ASHG24 - Check out our new methods to reveal population structure through time -- poster 3026F presented today by Ahmed Selim from the lab!

#ASHG24 make your way to today’s Novembre lab posters 3015 (label free reference matching, @LukeAnderTroc) 3016 (rare variant discovery, @maggiecsteiner ) and 4041 (impacts of multigeneration shared environments, @mkiravn) to see some great science!

Come join us! UChicago Human Genetics has an open broad computational faculty search (with an emphasis on probabilistic machine learning). First round of application review will begin ~October 15th. apply.interfolio.com/149891 EOE/Vet/Disability.

Allele ages provide limited information about the strength of negative selection https://www.biorxiv.org/content/10.1101/2024.08.06.606888v1

Just reposting James Kitchens blog post on pedigrees and the coalescent. As I'm using the R shiny he made for teaching again this year james-kitchens.com/blog/why-are...