New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason.bsky.social on - arxiv.org/abs/2510.17554

🔔 Excited to share our preprint from the largest ever exome-wide association study for T2D in South Asians. We make important discoveries implicating the genes HNF4A, GP2, RNF19A in the aetiology of diabetes and metabolic traits in south Asians. 👉 Read it here:

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities www.nature.com/articles/s41... Cool findings: Two obesity GRSs for stratification, one with cardiometabolic comorbidities (GRS_BFP) and one without (GRS_uncoupling)

Developing type 2 diabetes young+lean is not as uncommon as it may seem. This phenomenon is more common in people of South Asian and East Asian ancestry, but is observed across populations. Why does this happen, how should we screen and treat young+lean T2D. 👉 Read our paper here: rdcu.be/eH0YR

Body fat distribution predicts the pace of cardiovascular system aging, with sex-specific patterns, and protective effect of estrogen academic.oup.com/eurheartj/ad...

🚨 NEW RESEARCH! ⚕️ 🩺 Dzando et al. identify frailty thresholds for older people in Sub-Saharan Africa, accounting for differences compared to frailty thresholds in high-income countries. https://bit.ly/44QDcdy #FrailtyResearch

the deepest of sighs....

Exciting to see this lovely paper out! Many of us have been using the pre-print for a while to demonstrate ancestral heterogeneity in India. Congratulations to the authors!

Super exciting phase 1-2 results of restorative therapy for T1D just out at NEJM www.nejm.org/doi/full/10.... Imagine the transformative potential when paired with genetic + autoantibody screening in early life... nearly every T1D case could be prevented??🤞

Preprint alert! 🚨 doi.org/10.1101/2025... Our manuscript on Exome sequencing and analysis of 44,028 British South Asians, using @genesandhealth.bsky.social is now available at @medrxivpreprint.bsky.social! We present several great results, and I’m thrilled to highlight the pieces I worked on:

The war on science in the US is already having an effect on private sector research like AlphaFold. Bears repeating but the private sector builds on top of things created by academic research for the public good. This hurts everyone.

🎉 This paper has been a long time and a labour of love (and hardship) for multiple group members, but, finally: we MPRA'ed 25k introgressed variants (Denisovan and Neanderthal) segregating at allele frequencies > 0.15 in humans today to evaluate their potential to regulate gene expression.

British Steel employs 3.6k people. Coventry Uni group, which auditors say may not survive, employs 7.7k. But there is an emergency debate in parliament for British Steel and nothing for the whole HE sector imploding

"I cannot [bring] myself morally to spend Canadian taxpayers’ money in attending U.S. conferences." My latest story for @science.org—about international scientists rethinking conferences on U.S. soil. www.science.org/content/arti...

Managing diabetes during Ramadan is key to fasting safely. Check out this free online course by BIMA & DaR to help healthcare professionals & Muslim patients make informed decisions. 📅 6 Jan – 31 Mar 2025 🔗 Access here: pn.mydiabetes.com/resources/in...

Celebrating the incredible women of Genes & Health on #InternationalWomensDay 💜 👩‍⚕️ 35,920 women participating in the study 👩‍🔬 15 women working across London, Bradford, Manchester, and Birmingham 🙌 16 women on our Community Advisory Board 👩‍🏫 5 women on the Genes & Health Executive Thank you to all!

Genes & Health contributed to a major study on heart failure genetics, published in Nature Genetics. Using data from 1.9M individuals, researchers identified 66 genetic loci, including 37 new discoveries. Inclusive research ensures prevention & treatment for all. Read more: lnkd.in/dFmMHfKi

New research by an international team led by @qmul.ac.uk have found new genetic links between genetically-predicted height and an individual’s likelihood of developing a range of diseases and conditions. These new data could help improve early diagnosis and risk monitoring for patients.

Many scientists like myself have held tepid liberal views, while ignoring genocides and colonisation. Now these forces have joined with research funding cuts, targeting minority, gender+LGBTQI research. Time to wake up and connect the dots. Be like Macklemore✊ youtu.be/sn9EKC9nqU4?...

So delighted to be joining QMUL and Barts at the inaugural Professor of Clinical Epidemiology and Predictive Medicine. One of the most technically advanced and largest NHS Trusts in the country in the culturally richest and most diverse parts of the UK

It would be much clearer to call these studies differential methylation analyses, analogously to differential expression. THAT is actually the relevant reference in terms of hypothesis, model and caveats, rather than GWAS.

1 h-PG can detect Asians at risk of developing T2DM within three years. www.thelancet.com/journals/lan...

Comparing DXA and MRI body composition measurements in cross-sectional and longitudinal cohorts https://www.medrxiv.org/content/10.1101/2024.12.12.24318943v1

The tech bro fascination with eugenics is so on brand. The idea that you could make accurate, actionable predictions from individual genotypes (with all their complex, non-linear interactions) from averaged, linearly modeled population-level genomic statistics is just another big data fantasy

I'm working on a little feature for Circa. It's been over a month since I really coded with all the other startup things like marketing and "strategic thinking" taking up my brain space, so it's really nice just to sit down and code a little algorithm and some SVG paths for overlap-avoiding text.

Hello! I’ve made it over here the other place wasn’t so great to hang out anymore!!

Professor @sarahfiner.bsky.social & Dr. @moneeza-ks.bsky.social joined @claudiahammond.bsky.social on #BBC World Service's Health Check! They discussed genetic drivers of early-onset type 2 diabetes in British South Asians & its impact on care. Listen: www.bbc.co.uk/sounds/play/...

Want to know more about our recent research into the genetic risks of type 2 diabetes in South Asian populations? The very wonderful Prof @sarahfiner.bsky.social and Dr @moneeza-ks.bsky.social have been speaking about their work on the BBC World Service's Health Check: www.bbc.co.uk/programmes/w...

Learn more about our latest research published in Nature through this interesting conversation between Professor @sarahfiner.bsky.social and Dr @moneeza-ks.bsky.social who discuss the genetic causes of early-onset type 2 diabetes in British South Asians. www.linkedin.com/feed/update/...

Journal clubbed this paper by Daniel Coral, Femke Smit, @paulwfranks.bsky.social, and colleagues. The writing simplifies complex methods brilliantly, and the GitHub materials are exceptional, setting a high standard for reproducible science. Tremendous work! www.nature.com/articles/s41...

In "Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota", @inanna-nalytica.bsky.social showed that a supposed T2D #microbiome signature is actually driven by drug treatment with metformin (2015) www.nature.com/artic...

It’s so cool that we can measure this now. A big reason why new drugs fail? To say nothing of tissue-specific and cell-specific effects!

Calling all FMD colleagues! We have put together a Starter Pack of academic staff from the Faculty of Medicine and Dentistry who are here on BlueSky. Please share, and do message me if you would like to be included! go.bsky.app/CsNph6c

The relationship between irregular sleep pattern and major adverse cardiovascular events in over 70,000 UK Biobank participants with accelerometer assessment, not titrated by sleep duration jech.bmj.com/content/earl...

Ok, folks, bear with us - this is the first video we're posting to BlueSky so the format may not be quite right... but it's Professor Sarah Finer and Dr Moneeza Siddiqui discussing their findings, so it's worth it!

Delighted to showcase @genesandhealth.bsky.social and the enormous work of teams across settings. In this piece we highlight its role in diabetes & metabolism research. authors.elsevier.com/a/1kAgM3jDgW... @qmulfmd.bsky.social @sarahfiner.bsky.social #SouthAsianHealth #PrecisionMedicine

Paper from Sarah Finer, Moneeza Siddiqui and team. bsky.app/profile/sara...

Hello Bluesky 👋 We are Genes&Health, one of the world's largest community-based genetics study improving the health of South Asian people. Join us in shaping the future of healthcare. Follow along to know more about how to volunteer, our achievements and the future of our research.

It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵

Among British Pakistani & British Bangladeshi individuals, partitioned T2D polygenic load for insulin deficiency & lipodystrophy was higher than white European individuals & predisposed to faster progression to T2D & complications www.nature.com/articles/s41... @natureportfolio.bsky.social

BlueSky premier 🎞️ talking about exciting work led by @samcbhodgson.bsky.social. Link to paper: rdcu.be/d1vj0 Detailed summary by yours truly: bsky.app/profile/mone...

Genes&Health, @samcbhodgson.bsky.social @sarahfiner.bsky.social & I are very pleased to share the 1st study using partitioned polygenic scores to understand age of T2D onset, GDM, lean T2D &💊response. All this in a south Asian cohort –typically under-represented in 🧬 research @qmul.bsky.social

Impressive work by @jonicoleman.bsky.social keeping up with my ramblings at #SEGEG2024! Presented some exciting new results from the #Genes&Health study. More in the news soon! Great fun being at specialist meetings like this. @qmul-wiph.bsky.social

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.

NEWS! Check our wrap-up about #ashg24 shorturl.at/WcTiz Something is missing? Let us know! 🙌 Thanks, ASHG, for giving us the floor to share updates with #genetics community, delivered by our colleague @mariacerezo.bsky.social #OpenAccess #gwas #gwasdatahero Stronger together @ebi.embl.org @NIH