How do you join the gVasc Research Study? Visit gvascstudy.org 💻 and follow these easy steps! Complete a few short surveys about your health and receive the saliva kit in the mail 📝 📦 ❤️ #scad #heartresearch #scadalliance @scadalliance.bsky.social @pnatarajanmd.bsky.social @markelindsay.bsky.social

In the Summer we usually slow down… 🏖️ but here are some Fast Facts ⏱️🗒️ about spontaneous coronary artery dissection (SCAD). Visit gvascstudy.org to learn more about the gVasc study today🫀 #SCAD #heartresearch #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

Meet the Team! 🩺 gVasc investigators have extensive experience in cardiovascular disease and genetics🫀🧬 They bring together their expertise to uncover the genetic underpinnings of SCAD 🔍 gvascstudy.org #SCAD #cardiology @scadalliance.bsky.social @markelindsay.bsky.social @pnatarajanmd.bsky.social

gVasc is a research study trying to find out if there are genetic factors behind why SCAD happens🫀Click the link in our bio or head to gvascstudy.org to learn more about our study and to participate! #gvasc #SCAD #research #heart #hearthealth #heartresearch #scadalliance @scadalliance.bsky.social

🗓️ At #CSANZ2025? JAMA Associate Editors @rohankhera.bsky.social‬, MD, MS and @pnatarajanmd.bsky.social, MD, MMSc, will be at Plaza 4 today, Saturday, August 16 from 3 PM to 3:30 PM. ➡️ Stop by to ask questions ➡️ Learn about publishing opportunities @cardiacsociety.bsky.social

Our study led by T. Bellomo and with @aniruddhpatelmd.bsky.social describes the relationship between lipoprotein(a) and incident & progressive extracoronary atherosclerotic vascular disease www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @broadinstitute.org @mgbresearch.bsky.social

New polygenic risk score for obesity predicts response with weight loss across 2 lifestyle intervention RCTs nature.com/articles/s41... @natureportfolio.nature.com My comments in @nytimes.com nytimes.com/2025/07/21/h...

Should I tell anyone that I suspect misconduct in a paper I’m reviewing? So important and with more ECRs reviewing this guidance is very welcome. Things to keep in mind: - Extend the benefit of the doubt - Talk to the editor - Check your tone - Balance your responsibilities and your limits

Delighted to collaborate on this work led by @kellybolton.bsky.social describing how germline genetic variation influences the trajectory of clonal hematopoiesis to hematologic malignancy www.nature.com/articles/s41... @natureportfolio.nature.com @broadinstitute.org @mgbresearch.bsky.social

An abs risk generalizable risk calculator is challenging. Led by @somijemmacho.bsky.social, evaluating AHA PREVENT across 4 academic health systems, we found similar discrimination but variable calibration. A universal abs risk threshold may not suitably guide www.sciencedirect.com/science/arti...

Thrilled that our work on integrating genetic, contemporary and traditional risk factors into acute MI models has been published in @CirculationGenomeandPrecisionMedicine @ahascience.bsky.social !! Are genetic and contemporary risk factors as powerful as traditional RFs? #CardioSky #cvPrev

Our study led by @romitb.bsky.social & C. Marnell shows that, when simultaneously considering clinical, laboratory, and genetic risk factors for incident CAD prediction, the top 2 model explanatory factors are: 1. Hypertension 2. CAD polygenic risk score www.ahajournals.org/doi/10.1161/...

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

Delighted to write this viewpoint with C. Tcheandjieu & C. Robinson on gleaning and translating genomic insights across communities www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social

Our study led by A. Flores & with @aniruddhpatelmd.bsky.social describes a new peripheral artery disease PRS. Predictive capability for incident PAD is comparable to CKD & DM2. Among those with PAD, it also associates with major adv limb events jamanetwork.com/journals/jam... @jama.com #JAMACardio

📣 Psychological & behavioural considerations for integrating polygenic risk scores for disease into clinical practice www.nature.com/articles/s41... Saskia Sanderson & I wrote a piece assessing the common concern that PRS may have psych/behavioural harms tl;dr 👉 There's little/no evidence for this

Very excited to Chair this webinar on Cardiovascular Health May 21 7:30-8:30p ET hosted by @indiaspora.bsky.social with Opening Remarks from Vivek Murthy. Register us02web.zoom.us/meeting/regi... @drmarthagulati.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social .

Among N=2530 w HeFH or ASCVD on max tolerated LLT with insufficiently low LDL-C (mean 98mg/dl), obicetrapib (CETPi) 10mg po daily v placebo led to 33% lower LDL-C at 3mo www.nejm.org/doi/full/10.... @nejm.org #EAS2025

A cross-ancestry integrated (clinical + genetic) coronary artery disease risk score outperforms the Pooled Cohort Equations alone for CAD risk prediction across 4 cohorts www.nature.com/articles/s44...

The most math equations written on a whiteboard by a clinician I've seen - yet amazingly well delivered to a broad audience! S. Urbut's talk @broadinstitute.org A Practical Primer on Bayesian Statistics youtube.com/watch?v=jcFS... @mgbresearch.bsky.social @harvardmed.bsky.social

End of an era icelandmonitor.mbl.is/news/news/20...

Great paper on the intrinsic link between LDL and diabetes risk from @pnatarajanmd.bsky.social @skoyama.bsky.social @somijemmacho.bsky.social and colleagues: jamanetwork.com/journals/jam...

Out today in AJHG, this work from my (recently graduated) student Teng Heng on recessive effects in 44k British South Asians from the Genes & Health project @genesandhealth.bsky.social . She found 185 independent hits of which >40% were novel. Worth looking for these in your own cohorts!

The OurHealth Study – Discovering the Causes Behind High Rates of Cardiovascular Disease and Diabetes in South Asians www.indiaspora.org/the-ourhealt... @indiaspora.bsky.social Please sign up and share! ourhealthstudy.org @romitb.bsky.social

Our study led by A. Shankar shows that genotype-phenotype discordance of LDL-C (stronger polygenic predisposition to hypercholesterolemia for a given LDL-C) stratifies CAD risk - esp in normocholesterolemia. www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCADv

Had a great time working on this project - so thrilled to see this work finally out now!!

Honored to contribute to the @aspcardio.bsky.social Clinical Practice Statement on optimizing cardiometabolic health among South Asian individuals spearheaded by A. Rohatgi @drmarthagulati.bsky.social J. Patel www.sciencedirect.com/science/arti...

Study finds that Non-DNMT3A CHIP was associated with CKD progression among individuals with CKD, and Tet2-CHIP mouse models support a causal role in kidney injury. https://bit.ly/JASN0680 @drflashheart.bsky.social @pnatarajanmd.bsky.social @zhiyu.bsky.social #ASNJASN

In patients with CKD, non-DNMT3A CHIP was associated with cardiovascular disease with an effect size similar to that reported in the general population. https://bit.ly/JASN0671 #ASNJASN @drflashheart.bsky.social @pnatarajanmd.bsky.social @zhiyu.bsky.social

Very excited to share our preprint led by M. Levin @skoyama.bsky.social J. Woerner & with S. Damrauer assessing genome-wide pleiotropy of >1,000 clinical traits across ~1.7M individuals with nearly 30K locus-trait associations! www.medrxiv.org/content/10.1... @medrxivpreprint.bsky.social

Huge congrats to our clinical research coordinator Aarushi Bhatnagar on her oral presentation on the diversity of religious-language-regional groups in the OurHealthStudy (www.ourhealthstudy.org) @accintouch.bsky.social #ACC25 #SouthAsianCVD @aagarwalamd.bsky.social @pnatarajanmd.bsky.social

Direct-to-Consumer genetic testing for cardiovascular disease: A scientific statement from the AHA www.ahajournals.org/doi/10.1161/... Pragmatic overall. Patients are showing up to clinics with DTC genetics and we need to an approach to manage, ultimately leading to standards for the DTC industry.

Interested in learning more about genome editing tool dev & their application to treat human diseases? 🧬 🏥 We're hiring graduating seniors who are seeking ~2 years of post-bac research experience. If you're interested in gaining experience in next gen medicines, please reach out and apply! Link 👇

Delighted to share our American Heart Association Scientific Statement on Direct-to-Consumer Genetic Testing for Cardiovascular Disease! www.ahajournals.org/doi/10.1161/... @ahascience.bsky.social @ahajournals.bsky.social

CAUGHT-CAD trial: Among N=365 intermediate risk w a family history of CAD with CAC 1-400, CAC-informed care (lifestyle + statins) vs usual care mitigated plaque progression on CCTA. @pnatarajanmd.bsky.social discussed findings & implications w T. Marwick. jamanetwork.com/journals/jam... @jama.com

Tomorrow we welcome @pnatarajanmd.bsky.social as an Associate Editor for cardiology. Dr Natarajan previously served as an Associate Editor at JAMA Cardiology & as an Associate Editor for Science Advances. He currently holds positions at @massgeneralbrigham.bsky.social & @harvardmed.bsky.social.

Good to see a score-of-scores approach continuing to build better more stable PGS👇 We've widely used these methods (eg metaGRS/integrative PGS) at least since 2017-18... they rest on the ensembling principle for noisy predictions. Indeed many biomarkers are v noisy but not easily ensembled like PGS

East & South Asian-Specific BP Trajectories & CVD #CardioSky #cvPrev #Hypertension www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @pnatarajanmd.bsky.social @mchonig.bsky.social @romitb.bsky.social @somijemmacho.bsky.social @psatishmd.bsky.social @drmonalidesai.bsky.social

Individual polygenic risk scores for the same trait can yield different results due to various derivation differences. Our study led by A. Misra & w A. Patel demonstrates how successive integration of scores can improve accuracy & stability www.nature.com/articles/s41... @naturecomms.bsky.social

So fantastic that NPR featured the unexplained troublingly high rates of heart disease among S Asian individuals, and our research efforts with the OurHealth Study to address these issues! www.npr.org/2025/02/11/n... @broadinstitute.org @prsdiversity.bsky.social

📢Out now! @xihonglin.bsky.social, @pnatarajanmd.bsky.social and colleagues present a framework for functionally-informed multi-trait rare variant analysis of biobank-scale sequencing studies. www.nature.com/articles/s43... #stats 🖥️ 🧬 🔓https://rdcu.be/d82Fx

🧬🫀In a genotype-first context, no HCM observed over 10 yr median follow-up in pheno-negative carriers of P/LP HCM variants

Our paper led by J. Shin & A. Small evaluating the longitudinal penetrance of HCM alleles in the Mass General Brigham Biobank www.sciencedirect.com/science/arti... @jaccjournals.bsky.social #JACCAdv @broadinstitute.org @cgm-mgh.bsky.social @mgbresearch.bsky.social

Fantastic Cardiology Grand Rounds on advances in polygenic risk scores from field leader Pradeep Natarajan @pnatarajanmd.bsky.social, introduced by our own Hattie Chung @hattaca.bsky.social

Punxsutawney Phil is only 35% accurate(!) but Staten Island Chuck is 85% accurate www.noaa.gov/heritage/sto... Unlike Punxsutawney Phil, Staten Island Chuck predicts *early* Spring www.cbsnews.com/newyork/news... #GroundhogDay

Dynamic Importance of Genomic & Clinical Risk for CAD Over the Life Course #CardioSky #MedSky #Circulation www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social @pnatarajanmd.bsky.social @erinmichos.bsky.social @jimjanuzzi.bsky.social @anastasiasmihaili.bsky.social @psatishmd.bsky.social

We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2 Diabetes," now published in JAMA Cardiology, led by the brilliant undergrad x.com/akshayaravi22 🎉 jamanetwork.com/journals/jam...

Delighted to share our study by S. Urbut with A. Fahed on adding in a CAD polygenic risk score to clinical factors to boost CAD risk prediction, particularly for recovering premature CAD events www.ahajournals.org/doi/10.1161/... @broadinstitute.org @mgbresearch.bsky.social

🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal, 👉 gvascstudy.org 👈

Very cool paper. Something I have always been curious about is the extent to which rare burden trait-specific genes are themselves regulators of pleiotropic genes. I.e. the genes on the bottom are TFs for the variants on the top.